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2ZC5

Penicillin-binding protein 1A (PBP 1A) acyl-enzyme complex (biapenem) from Streptococcus pneumoniae

Summary for 2ZC5
Entry DOI10.2210/pdb2zc5/pdb
Related2ZC3 2ZC4 2ZC6
DescriptorPenicillin-binding protein 1A, ZINC ION, (4R,5S)-3-(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium-6-ylsulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-meth yl-4,5-dihydro-1H-pyrrole-2-carboxylate, ... (5 entities in total)
Functional Keywordspeptidoglycan synthesis, cell wall, penicillin-binding, antibiotics, biapenem, antibiotic resistance, cell shape, cell wall biogenesis/degradation, multifunctional enzyme, secreted, biosynthetic protein
Biological sourceStreptococcus pneumoniae
More
Cellular locationSecreted: Q8DR59
Total number of polymer chains4
Total formula weight93639.87
Authors
Yamada, M.,Watanabe, T.,Takeuchi, Y. (deposition date: 2007-11-02, release date: 2008-04-08, Last modification date: 2023-11-01)
Primary citationYamada, M.,Watanabe, T.,Baba, N.,Takeuchi, Y.,Ohsawa, F.,Gomi, S.
Crystal Structures of Biapenem and Tebipenem Complexed with Penicillin-Binding Proteins 2X and 1A from Streptococcus pneumoniae
Antimicrob.Agents Chemother., 52:2053-2060, 2008
Cited by
PubMed: 18391040
DOI: 10.1128/AAC.01456-07
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3 Å)
Structure validation

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