1Z6F

Crystal structure of penicillin-binding protein 5 from E. coli in complex with a boronic acid inhibitor

Summary for 1Z6F

• Entry DOI: 10.2210/pdb1z6f/pdb
• Related: 1NJ4 1NZO 1NZU 1SDN
• Descriptor: Penicillin-binding protein 5, N1-[(1R)-1-(DIHYDROXYBORYL)ETHYL]-N2-[(TERT-BUTOXYCARBONYL)-D-GAMMA-GLUTAMYL]-N6-[(BENZYLOXY)CARBONYL-L-LYSINAMIDE, GLYCEROL, ... (4 entities in total)
• Functional Keywords: peptidoglycan synthesis, penicillin-binding protein, dd-carboxypeptidase, hydrolase, boronic acid
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 40513.65

Authors

Nicola, G.,Peddi, S.,Stefanova, M.,Nicholas, R.A.,Gutheil, W.G.,Davies, C. (deposition date: 2005-03-22, release date: 2005-06-21, Last modification date: 2023-08-23)

• Primary citation: Nicola, G.,Peddi, S.,Stefanova, M.,Nicholas, R.A.,Gutheil, W.G.,Davies, C.; Crystal Structure of Escherichia coli Penicillin-Binding Protein 5 Bound to a Tripeptide Boronic Acid Inhibitor: A Role for Ser-110 in Deacylation.; Biochemistry, 44:8207-8217, 2005; PubMed: 15938610; DOI: 10.1021/bi0473004

Experimental method

X-RAY DIFFRACTION (1.6 Å)