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5CXW

Structure of the PonA1 protein from Mycobacterium Tuberculosis in complex with penicillin V

Summary for 5CXW
Entry DOI10.2210/pdb5cxw/pdb
Related5CRF
DescriptorPenicillin-binding protein 1A, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, (2R,4S)-5,5-dimethyl-2-{(1R)-2-oxo-1-[(phenoxyacetyl)amino]ethyl}-1,3-thiazolidine-4-carboxylic acid, ... (5 entities in total)
Functional Keywordsb-lactam, pbp, structural genomics, psi-biology, midwest center for structural genomics, mcsg, structures of mtb proteins conferring susceptibility to known mtb inhibitors, mtbi, penicillin-binding protein-antibiotic complex, penicillin-binding protein/antibiotic
Biological sourceMycobacterium tuberculosis
Cellular locationCell membrane ; Single-pass membrane protein : P71707
Total number of polymer chains1
Total formula weight45112.30
Authors
Primary citationFilippova, E.V.,Kieser, K.J.,Luan, C.H.,Wawrzak, Z.,Kiryukhina, O.,Rubin, E.J.,Anderson, W.F.
Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance.
Febs J., 283:2206-2218, 2016
Cited by
PubMed: 27101811
DOI: 10.1111/febs.13738
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.75 Å)
Structure validation

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