5CXW
Structure of the PonA1 protein from Mycobacterium Tuberculosis in complex with penicillin V
Summary for 5CXW
Entry DOI | 10.2210/pdb5cxw/pdb |
Related | 5CRF |
Descriptor | Penicillin-binding protein 1A, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, (2R,4S)-5,5-dimethyl-2-{(1R)-2-oxo-1-[(phenoxyacetyl)amino]ethyl}-1,3-thiazolidine-4-carboxylic acid, ... (5 entities in total) |
Functional Keywords | b-lactam, pbp, structural genomics, psi-biology, midwest center for structural genomics, mcsg, structures of mtb proteins conferring susceptibility to known mtb inhibitors, mtbi, penicillin-binding protein-antibiotic complex, penicillin-binding protein/antibiotic |
Biological source | Mycobacterium tuberculosis |
Cellular location | Cell membrane ; Single-pass membrane protein : P71707 |
Total number of polymer chains | 1 |
Total formula weight | 45112.30 |
Authors | Filippova, E.V.,Kiryukhina, O.,Kieser, K.,Endres, M.,Rubin, E.,Sacchettini, J.,Joachimiak, A.,Anderson, W.F.,Midwest Center for Structural Genomics (MCSG),Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI) (deposition date: 2015-07-29, release date: 2016-05-04, Last modification date: 2023-09-27) |
Primary citation | Filippova, E.V.,Kieser, K.J.,Luan, C.H.,Wawrzak, Z.,Kiryukhina, O.,Rubin, E.J.,Anderson, W.F. Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance. Febs J., 283:2206-2218, 2016 Cited by PubMed: 27101811DOI: 10.1111/febs.13738 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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