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1TOO	Interleukin 1B Mutant F146W Descriptor: Interleukin-1 beta Authors: Adamek, D.H, Guerrero, L, Caspar, D.L. Deposit date: 2004-06-14 Release date: 2004-12-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural and energetic consequences of mutations in a solvated hydrophobic cavity. J.Mol.Biol., 346, 2005
1TWM	Interleukin-1 Beta Mutant F146Y Descriptor: Interleukin-1 beta Authors: Adamek, D.H, Capsar, D.L. Deposit date: 2004-07-01 Release date: 2004-12-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.26 Å) Cite: Structural and energetic consequences of mutations in a solvated hydrophobic cavity. J.Mol.Biol., 346, 2005
1TWE	INTERLEUKIN 1 BETA MUTANT F101Y Descriptor: Interleukin-1 beta Authors: Adamek, D.H, Capsar, D.L. Deposit date: 2004-06-30 Release date: 2004-12-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural and energetic consequences of mutations in a solvated hydrophobic cavity. J.Mol.Biol., 346, 2005
1T4Q	Interleukin 1 beta F101W Descriptor: Interleukin-1 beta Authors: Adamek, D.H, Guerrero, L, Caspar, D.L. Deposit date: 2004-04-30 Release date: 2004-12-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural and energetic consequences of mutations in a solvated hydrophobic cavity. J.Mol.Biol., 346, 2005
1TP0	Triple mutation in interleukin 1 beta cavity:replacement of phenylalanines with tryptophan. Descriptor: Interleukin-1 beta Authors: Adamek, D.H, Guerrero, L, Caspar, D.L. Deposit date: 2004-06-15 Release date: 2005-02-08 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural and energetic consequences of mutations in a solvated hydrophobic cavity. J.Mol.Biol., 346, 2005
2NVH	Determination of Solvent Content in Cavities in Interleukin-1 Using Experimentally-Phased Electron Density Descriptor: Interleukin-1 beta, SULFATE ION Authors: Quillin, M.L, Matthews, B.W. Deposit date: 2006-11-12 Release date: 2006-12-12 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Determination of solvent content in cavities in IL-1beta using experimentally phased electron density Proc.Natl.Acad.Sci.Usa, 103, 2006
3F62	Crystal Structure of Human IL-18 in complex with Ectromelia virus IL-18 Binding Protein Descriptor: Interleukin 18 binding protein, Interleukin-18 Authors: Krumm, B.E, Li, Y, Deng, J. Deposit date: 2008-11-05 Release date: 2009-01-06 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural basis for antagonism of human interleukin 18 by poxvirus interleukin 18-binding protein. Proc.Natl.Acad.Sci.USA, 105, 2008
2VXT	Crystal structure of human IL-18 complexed to murine reference antibody 125-2H Fab Descriptor: CHLORIDE ION, INTERLEUKIN-18, MAGNESIUM ION, ... Authors: Argiriadi, M.A, Xiang, T, Wu, C, Ghayur, T, Borhani, D.W. Deposit date: 2008-07-10 Release date: 2009-06-23 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.49 Å) Cite: Unusual Water-Mediated Antigenic Recognition of the Proinflammatory Cytokine Interleukin-18. J.Biol.Chem., 284, 2009
2KH2	Solution structure of a scFv-IL-1B complex Descriptor: Interleukin-1 beta, scFv Authors: Wilkinson, I.C, Hall, C.J, Veverka, V, Muskett, F.W, Stephens, P.E, Taylor, R.J, Henry, A.J, Carr, M.D. Deposit date: 2009-03-23 Release date: 2009-09-08 Last modified: 2022-03-16 Method: SOLUTION NMR Cite: High resolution NMR-based model for the structure of a scFv-IL-1beta complex: potential for NMR as a key tool in therapeutic antibody design and development. J.Biol.Chem., 284, 2009
2KKI	Solution structure of human Interleukin 1a Descriptor: Interleukin-1 alpha Authors: Mohan, S.K, Chang, H.-K, Yu, C. Deposit date: 2009-06-24 Release date: 2010-06-30 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: 1H, 13C and 15N backbone and side chain resonance assignments of human interleukin 1alpha Biomol.Nmr Assign., 4, 2010
3O4O	Crystal structure of an Interleukin-1 receptor complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-1 beta, ... Authors: Wang, X.Q, Wang, D.L, Zhang, S.Y, Li, L, Liu, X, Mei, K.R. Deposit date: 2010-07-27 Release date: 2010-09-01 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Structural insights into the assembly and activation of IL-1beta with its receptors Nat.Immunol., 11, 2010
2WRY	Crystal structure of chicken cytokine interleukin 1 beta Descriptor: INTERLEUKIN-1BETA Authors: Lu, W.S, Cheng, C.S, Lyu, P.C, Lee, L.H, Wang, W.C, Yin, H.S. Deposit date: 2009-09-03 Release date: 2010-09-29 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.58 Å) Cite: Structural and Functional Comparison of Cytokine Interleukin-1 Beta from Chicken and Human. Mol.Immunol., 48, 2011
3POK	Interleukin-1-beta LBT L3 Mutant Descriptor: Interleukin-1 beta Authors: Barthelmes, K, Reynolds, A.M, Peisach, E, Jonker, H.R.A, DeNunzio, N.J, Allen, K.N, Imperiali, B, Schwalbe, H. Deposit date: 2010-11-22 Release date: 2011-01-19 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Engineering encodable lanthanide-binding tags into loop regions of proteins. J.Am.Chem.Soc., 133, 2011
2L5X	Solution structure of IL1A-S100A13 complex Descriptor: Interleukin-1 alpha, Protein S100-A13 Authors: Mohan, S.K, Yu, C. Deposit date: 2010-11-09 Release date: 2011-01-26 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: The IL1alpha-S100A13 heterotetrameric complex structure: a component in the non-classical pathway for interleukin 1alpha secretion J.Biol.Chem., 286, 2011
3LTQ	Structure of Interleukin 1B solved by SAD using an inserted Lanthanide Binding Tag Descriptor: ACETATE ION, Interleukin-1 beta, SULFATE ION, ... Authors: Peisach, E, Allen, K.N. Deposit date: 2010-02-16 Release date: 2011-02-16 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Engineering encodable lanthanide-binding tags into loop regions of proteins. J.Am.Chem.Soc., 133, 2011
3NJ5	Crystal structure of chicken IL-1 hydrophobic cavity mutant 157 Descriptor: IL-1 beta Authors: Yin, H.S, Chen, Y.W. Deposit date: 2010-06-17 Release date: 2011-06-22 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.67 Å) Cite: Structural and functional comparison of cytokine interleukin-1 beta from chicken and human Mol.Immunol., 48, 2011
4DEP	Structure of the IL-1b signaling complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-1 beta, Interleukin-1 receptor accessory protein, ... Authors: Thomas, C, Garcia, K.C. Deposit date: 2012-01-21 Release date: 2012-03-21 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Structure of the activating IL-1 receptor signaling complex. Nat.Struct.Mol.Biol., 19, 2012
4EKX	Crystal Structure of YLDV 14L IL-18 Binding Protein in Complex with Human IL-18 Descriptor: 14L protein, Interleukin-18 Authors: Krumm, B.E, Xiang, Y, Deng, J. Deposit date: 2012-04-10 Release date: 2012-09-26 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (1.75 Å) Cite: A unique bivalent binding and inhibition mechanism by the yatapoxvirus interleukin 18 binding protein. Plos Pathog., 8, 2012
4EEE	Crystal Structure of YLDV 14L IL-18 Binding Protein in Complex with Human IL-18 Descriptor: 14L protein, Interleukin-18 Authors: Krumm, B.E, Xiang, Y, Deng, J. Deposit date: 2012-03-28 Release date: 2012-09-26 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.71 Å) Cite: A unique bivalent binding and inhibition mechanism by the yatapoxvirus interleukin 18 binding protein. Plos Pathog., 8, 2012
4G6J	Crystal structure of human IL-1beta in complex with the therapeutic antibody binding fragment of canakinumab Descriptor: Interleukin-1 beta, heavy chain of antibody binding fragment of canakinumab, light chain of antibody binding fragment of canakinumab Authors: Blech, M, Hoerer, S. Deposit date: 2012-07-19 Release date: 2012-12-19 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.03 Å) Cite: One traget-two different binding modes: Structural insights into gevokizumab and canakinumab interactions to interleukin-1beta J.Mol.Biol., 425, 2013
4G6M	Crystal structure of human IL-1beta in complex with therapeutic antibody binding fragment of gevokizumab Descriptor: Interleukin-1 beta, heavy chain of gevokizumab antibody binding fragment, light chain of gevokizumab antibody binding fragment Authors: Blech, M, Hoerer, S. Deposit date: 2012-07-19 Release date: 2012-12-19 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Crystal structure of human IL-1beta in complex with therapeutic antibody binding fragment of gevokizumab J.Mol.Biol., 425, 2013
4GAF	Crystal structure of EBI-005, a chimera of human IL-1beta and IL-1Ra, bound to human Interleukin-1 receptor type 1 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, EBI-005, Interleukin-1 receptor type 1, ... Authors: Hou, J, Townson, S.A, Kovalchin, J.T, Masci, A, Kiner, O, Shu, Y, King, B, Thomas, C, Garcia, K.C, Furfine, E.S, Barnes, T.M. Deposit date: 2012-07-25 Release date: 2013-02-20 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Design of a superior cytokine antagonist for topical ophthalmic use. Proc.Natl.Acad.Sci.USA, 110, 2013
4GAI	Crystal structure of EBI-005, a chimera of human IL-1beta and IL-1Ra Descriptor: EBI-005 Authors: Hou, J, Townson, S.A, Kovalchin, J.T, Masci, A, Kiner, O, Shu, Y, King, B, Thomas, C, Garcia, K.C, Furfine, E.S, Barnes, T.M. Deposit date: 2012-07-25 Release date: 2013-02-20 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.49 Å) Cite: Design of a superior cytokine antagonist for topical ophthalmic use. Proc.Natl.Acad.Sci.USA, 110, 2013
4HJJ	Structure Reveals Function of the Dual Variable Domain Immunoglobulin (DVD-Ig) Molecule Descriptor: Anti-IL12 Anti-IL18 DFab Heavy Chain, Anti-IL12 Anti-IL18 DFab Light Chain, CHLORIDE ION, ... Authors: Jakob, C.G, Edalji, R, Judge, R.A, DiGiammarino, E, Li, Y, Gu, J, Ghayur, T. Deposit date: 2012-10-12 Release date: 2013-05-08 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structure reveals function of the dual variable domain immunoglobulin (DVD-Ig[TM]) molecule MAbs, 5, 2013
4IZE	Crystal Structure of IL-36gamma Descriptor: Interleukin-36 gamma Authors: Guenther, S, Sundberg, E.J. Deposit date: 2013-01-29 Release date: 2014-06-25 Last modified: 2014-07-16 Method: X-RAY DIFFRACTION (2 Å) Cite: Molecular Determinants of Agonist and Antagonist Signaling through the IL-36 Receptor. J.Immunol., 193, 2014

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