3UH0
| Crystal structure of the yeast mitochondrial threonyl-tRNA synthetase (MST1) in complex with threonyl sulfamoyl adenylate | Descriptor: | 5'-O-(N-(L-THREONYL)-SULFAMOYL)ADENOSINE, SULFATE ION, Threonyl-tRNA synthetase, ... | Authors: | Peterson, K.M, Ling, J, Simonovic, I, Cho, C, Soll, D, Simonovic, M. | Deposit date: | 2011-11-03 | Release date: | 2012-02-22 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Yeast mitochondrial threonyl-tRNA synthetase recognizes tRNA isoacceptors by distinct mechanisms and promotes CUN codon reassignment. Proc.Natl.Acad.Sci.USA, 109, 2012
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6SWX
| Leishmania major methionyl-tRNA synthetase in complex with an allosteric inhibitor | Descriptor: | METHIONINE, Putative methionyl-tRNA synthetase, methyl 2-[[6-[[3,4-bis(fluoranyl)phenyl]amino]-1-methyl-pyrazolo[3,4-d]pyrimidin-4-yl]amino]ethanoate | Authors: | Robinson, D.A, Torrie, L.S, Shepherd, S.M, De Rycker, M, Thomas, M.G, Wyatt, P.G. | Deposit date: | 2019-09-24 | Release date: | 2020-08-05 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase. Acs Infect Dis., 6, 2020
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3TEG
| Bacterial and Eukaryotic Phenylalanyl-tRNA Synthetases Catalyze Misaminoacylation of tRNAPhe with 3,4-Dihydroxy-L-Phenylalanine (L-Dopa) | Descriptor: | 3,4-DIHYDROXYPHENYLALANINE, Phenylalanyl-tRNA synthetase, mitochondrial | Authors: | Moor, N, Klipcan, L, Safro, M. | Deposit date: | 2011-08-14 | Release date: | 2011-11-23 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.2044 Å) | Cite: | Bacterial and Eukaryotic Phenylalanyl-tRNA Synthetases Catalyze Misaminoacylation of tRNA(Phe) with 3,4-Dihydroxy-L-Phenylalanine. Chem.Biol., 18, 2011
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3UGQ
| Crystal structure of the apo form of the yeast mitochondrial threonyl-tRNA synthetase determined at 2.1 Angstrom resolution | Descriptor: | POTASSIUM ION, SULFATE ION, Threonyl-tRNA synthetase, ... | Authors: | Peterson, K.M, Ling, J, Simonovic, I, Cho, C, Soll, D, Simonovic, M. | Deposit date: | 2011-11-02 | Release date: | 2012-02-22 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Yeast mitochondrial threonyl-tRNA synthetase recognizes tRNA isoacceptors by distinct mechanisms and promotes CUN codon reassignment. Proc.Natl.Acad.Sci.USA, 109, 2012
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3TL4
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4FYJ
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5NFH
| Trypanosoma brucei methionyl-tRNA synthetase in complex with a quinazolinone inhibitor | Descriptor: | 2-[3-[[4,6-bis(chloranyl)-1~{H}-indol-2-yl]methylamino]propylamino]-3~{H}-quinazolin-4-one, DIMETHYL SULFOXIDE, GLYCEROL, ... | Authors: | Robinson, D.A, Eadsforth, T.C, Shepherd, S.M, Torrie, L.S, De Rycker, M, Gilbert, I.H. | Deposit date: | 2017-03-14 | Release date: | 2017-10-11 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani. ACS Infect Dis, 3, 2017
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8IFJ
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1TOB
| SACCHARIDE-RNA RECOGNITION IN AN AMINOGLYCOSIDE ANTIBIOTIC-RNA APTAMER COMPLEX, NMR, 7 STRUCTURES | Descriptor: | 1,3-DIAMINO-5,6-DIHYDROXYCYCLOHEXANE, 2,6-diammonio-2,3,6-trideoxy-alpha-D-glucopyranose, 3-ammonio-3-deoxy-alpha-D-glucopyranose, ... | Authors: | Jiang, L, Suri, A.K, Fiala, R, Patel, D.J. | Deposit date: | 1996-12-12 | Release date: | 1997-06-16 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Saccharide-RNA recognition in an aminoglycoside antibiotic-RNA aptamer complex. Chem.Biol., 4, 1997
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8POS
| Crystal structure of wolbachia leucyl-tRNA synthetase editing domain bound to cmpd9-AMP adduct | Descriptor: | Leucine--tRNA ligase, SULFATE ION, [(1R,3'S,5S,6R,8R)-3'-(aminomethyl)-8-(6-aminopurin-9-yl)-4'-bromanyl-7'-[3-[methyl-(phenylmethyl)amino]propoxy]spiro[2,4,7-trioxa-3$l^{4}-borabicyclo[3.3.0]octane-3,1'-3H-2,1$l^{4}-benzoxaborole]-6-yl]methyl dihydrogen phosphate | Authors: | Palencia, A, Hoffmann, G. | Deposit date: | 2023-07-05 | Release date: | 2024-06-12 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (2.137 Å) | Cite: | Targeting a microbiota Wolbachian aminoacyl-tRNA synthetase to block its pathogenic host. Sci Adv, 10, 2024
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8POQ
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6KAB
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6KA6
| Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 1 | Descriptor: | (3~{S})-3-[[(1~{S},3~{S})-3-methylcyclohexyl]methyl]-6,8-bis(oxidanyl)-3,4-dihydroisochromen-1-one, GLYCEROL, LYSINE, ... | Authors: | Zhou, J, Fang, P. | Deposit date: | 2019-06-21 | Release date: | 2020-04-08 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.891 Å) | Cite: | Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase. Acs Chem.Biol., 15, 2020
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6KCN
| Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 4 | Descriptor: | 3-[[(1~{S},3~{S})-3-methylcyclohexyl]methyl]-6,8-bis(oxidanyl)isochromen-1-one, GLYCEROL, LYSINE, ... | Authors: | Zhou, J, Fang, P. | Deposit date: | 2019-06-28 | Release date: | 2020-04-08 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase. Acs Chem.Biol., 15, 2020
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6KCT
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6KBF
| Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 3 | Descriptor: | (3~{S})-3-[[(1~{S},3~{S})-3-methylcyclohexyl]methyl]-6,8-bis(oxidanyl)-3,4-dihydro-2~{H}-isoquinolin-1-one, DIMETHYL SULFOXIDE, GLYCEROL, ... | Authors: | Zhou, J, Fang, P. | Deposit date: | 2019-06-24 | Release date: | 2020-04-08 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase. Acs Chem.Biol., 15, 2020
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3TCN
| Crystal structures of Peptidyl-tRNA hydrolase from Mycobacterium tuberculosis - Form 2 grown in presence of Pentaglycine | Descriptor: | Peptidyl-tRNA hydrolase | Authors: | Selvaraj, M, Ahmad, R, Varshney, U, Vijayan, M. | Deposit date: | 2011-08-09 | Release date: | 2012-02-15 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structures of new crystal forms of Mycobacterium tuberculosis peptidyl-tRNA hydrolase and functionally important plasticity of the molecule Acta Crystallogr.,Sect.F, 68, 2012
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5VAD
| Crystal structure of human Prolyl-tRNA synthetase (PRS) in complex with inhibitor | Descriptor: | 3-[(cyclohexanecarbonyl)amino]-N-(2,3-dihydro-1H-inden-2-yl)pyrazine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, PROLINE, ... | Authors: | Okada, K, Skene, R.J. | Deposit date: | 2017-03-24 | Release date: | 2017-05-31 | Last modified: | 2017-06-07 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Discovery of a novel prolyl-tRNA synthetase inhibitor and elucidation of its binding mode to the ATP site in complex with l-proline. Biochem. Biophys. Res. Commun., 488, 2017
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4AH6
| Human mitochondrial aspartyl-tRNA synthetase | Descriptor: | ASPARTATE--TRNA LIGASE, MITOCHONDRIAL | Authors: | Neuenfeldt, A, Sissler, M, Lorber, B, Florentz, C, Sauter, C. | Deposit date: | 2012-02-03 | Release date: | 2013-01-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Thermodynamic Properties Distinguish Human Mitochondrial Aspartyl-tRNA Synthetase from Bacterial Homolog with Same 3D Architecture Nucleic Acids Res., 41, 2013
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1ATI
| CRYSTAL STRUCTURE OF GLYCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS | Descriptor: | GLYCYL-TRNA SYNTHETASE, GLYCYL-tRNA SYNTHETASE | Authors: | Logan, D.T, Mazauric, M.-H, Kern, D, Moras, D. | Deposit date: | 1996-04-23 | Release date: | 1997-07-07 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Crystal structure of glycyl-tRNA synthetase from Thermus thermophilus. EMBO J., 14, 1995
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7RDN
| Crystal structure of S. cerevisiae pre-mRNA leakage protein 39 (Pml39) | Descriptor: | Pre-mRNA leakage protein 39, ZINC ION | Authors: | Hashimoto, H, Ramirez, D.H, Pawlak, N, Blobel, G, Palancade, B, Debler, E.W. | Deposit date: | 2021-07-09 | Release date: | 2022-07-27 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Structure of the pre-mRNA leakage 39-kDa protein reveals a single domain of integrated zf-C3HC and Rsm1 modules. Sci Rep, 12, 2022
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1ADJ
| HISTIDYL-TRNA SYNTHETASE IN COMPLEX WITH HISTIDINE | Descriptor: | HISTIDINE, HISTIDYL-TRNA SYNTHETASE, SULFATE ION | Authors: | Cusack, S, Aberg, A. | Deposit date: | 1997-02-18 | Release date: | 1997-08-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure analysis of the activation of histidine by Thermus thermophilus histidyl-tRNA synthetase. Biochemistry, 36, 1997
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1ADY
| HISTIDYL-TRNA SYNTHETASE IN COMPLEX WITH HISTIDYL-ADENYLATE | Descriptor: | HISTIDYL-ADENOSINE MONOPHOSPHATE, HISTIDYL-TRNA SYNTHETASE, SULFATE ION | Authors: | Cusack, S, Aberg, A. | Deposit date: | 1997-02-19 | Release date: | 1997-08-20 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure analysis of the activation of histidine by Thermus thermophilus histidyl-tRNA synthetase. Biochemistry, 36, 1997
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1ULH
| A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase | Descriptor: | Tryptophanyl-tRNA synthetase | Authors: | Kise, Y, Sengoku, T, Ishii, R, Yokoyama, S, Park, S.G, Lee, S.W, Kim, S, Nureki, O, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2003-09-12 | Release date: | 2004-02-03 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase Nat.Struct.Mol.Biol., 11, 2004
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3O0A
| Crystal structure of the wild type CP1 hydrolitic domain from Aquifex Aeolicus leucyl-trna | Descriptor: | Leucyl-tRNA synthetase subunit alpha | Authors: | Cura, V, Olieric, N, Wang, E.-D, Moras, D, Eriani, G, Cavarelli, J. | Deposit date: | 2010-07-19 | Release date: | 2010-11-17 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Crystal Structure of the Wild Type and Two Mutants of the Cp1 Hydrolytic Domain from Aquifex Aeolicus Leucyl-tRNA Synthetase To be Published
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