6KCN

Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 4

Summary for 6KCN

Entry DOI	10.2210/pdb6kcn/pdb
Descriptor	Lysine--tRNA ligase, 3-[[(1~{S},3~{S})-3-methylcyclohexyl]methyl]-6,8-bis(oxidanyl)isochromen-1-one, GLYCEROL, ... (5 entities in total)
Functional Keywords	inhibitor, complex, ligase
Biological source	Plasmodium falciparum (isolate NF54)
Total number of polymer chains	4
Total formula weight	241235.04
Authors	Zhou, J.,Fang, P. (deposition date: 2019-06-28, release date: 2020-04-08, Last modification date: 2023-11-22)
Primary citation	Zhou, J.,Zheng, L.,Hei, Z.,Li, W.,Wang, J.,Yu, B.,Fang, P. Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase. Acs Chem.Biol., 15:1016-1025, 2020 Cited by PubMed: 32195573 DOI: 10.1021/acschembio.0c00032 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation