5NFH

Trypanosoma brucei methionyl-tRNA synthetase in complex with a quinazolinone inhibitor

Summary for 5NFH

• Entry DOI: 10.2210/pdb5nfh/pdb
• Descriptor: Methionyl-tRNA synthetase, putative, GLYCEROL, DIMETHYL SULFOXIDE, ... (6 entities in total)
• Functional Keywords: synthetase, ligase, methionine, inhibitor, ligase-ligase inhibitor, complex, drug discovery
• Biological source: Trypanosoma brucei brucei
• Total number of polymer chains: 2
• Total formula weight: 122598.45

Authors

Robinson, D.A.,Eadsforth, T.C.,Shepherd, S.M.,Torrie, L.S.,De Rycker, M.,Gilbert, I.H. (deposition date: 2017-03-14, release date: 2017-10-11, Last modification date: 2024-01-17)

• Primary citation: Torrie, L.S.,Brand, S.,Robinson, D.A.,Ko, E.J.,Stojanovski, L.,Simeons, F.R.C.,Wyllie, S.,Thomas, J.,Ellis, L.,Osuna-Cabello, M.,Epemolu, O.,Nuhs, A.,Riley, J.,MacLean, L.,Manthri, S.,Read, K.D.,Gilbert, I.H.,Fairlamb, A.H.,De Rycker, M.; Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani.; ACS Infect Dis, 3:718-727, 2017; PubMed: 28967262; DOI: 10.1021/acsinfecdis.7b00047

Experimental method

X-RAY DIFFRACTION (2.8 Å)