5NFH
Trypanosoma brucei methionyl-tRNA synthetase in complex with a quinazolinone inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004825 | molecular_function | methionine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006431 | biological_process | methionyl-tRNA aminoacylation |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004825 | molecular_function | methionine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006431 | biological_process | methionyl-tRNA aminoacylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 801 |
| Chain | Residue |
| A | ARG583 |
| A | ARG601 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 802 |
| Chain | Residue |
| A | GLU732 |
| A | VAL733 |
| A | HOH939 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 803 |
| Chain | Residue |
| A | GLY573 |
| A | TYR574 |
| A | ASP575 |
| A | HOH980 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 804 |
| Chain | Residue |
| A | HIS395 |
| A | VAL396 |
| A | HOH941 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue DMS A 805 |
| Chain | Residue |
| A | DMS806 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue DMS A 806 |
| Chain | Residue |
| A | PHE370 |
| A | TYR526 |
| A | DMS805 |
| A | HOH1007 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue MET A 807 |
| Chain | Residue |
| A | ILE248 |
| A | TYR249 |
| A | TYR250 |
| A | ASP287 |
| A | TRP474 |
| A | THR549 |
| A | LYS550 |
| A | HOH912 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 801 |
| Chain | Residue |
| B | ARG583 |
| B | ARG601 |
| B | HOH999 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue DMS B 802 |
| Chain | Residue |
| B | PHE319 |
| B | GLU320 |
| B | TYR324 |
| B | ILE326 |
| site_id | AD1 |
| Number of Residues | 16 |
| Details | binding site for residue 8W2 B 803 |
| Chain | Residue |
| B | ILE248 |
| B | TYR250 |
| B | ASP287 |
| B | GLY290 |
| B | GLU368 |
| B | VAL471 |
| B | TYR472 |
| B | VAL473 |
| B | TRP474 |
| B | ASP476 |
| B | TYR481 |
| B | PHE522 |
| B | HOH958 |
| B | HOH972 |
| B | HOH987 |
| B | HOH1026 |
