6R1O
Crystal structure of E. coli seryl-tRNA synthetase complexed to a seryl sulfamoyl adenosine derivative
Summary for 6R1O
Entry DOI | 10.2210/pdb6r1o/pdb |
Descriptor | Serine--tRNA ligase, [(2~{R},3~{S},4~{R},5~{R})-5-(6-azanyl-2-pyridin-3-yl-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-[(2~{S})-2-azanyl-3-oxidanyl-propanoyl]sulfamate, CHLORIDE ION, ... (8 entities in total) |
Functional Keywords | aminoacyl-trna synthetase, class ii, protein synthesis, inhibitor, ligase |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 51893.45 |
Authors | Salimraj, R.,Cain, R.,Roper, D.I. (deposition date: 2019-03-14, release date: 2020-01-22, Last modification date: 2024-01-24) |
Primary citation | Cain, R.,Salimraj, R.,Punekar, A.S.,Bellini, D.,Fishwick, C.W.G.,Czaplewski, L.,Scott, D.J.,Harris, G.,Dowson, C.G.,Lloyd, A.J.,Roper, D.I. Structure-Guided Enhancement of Selectivity of Chemical Probe Inhibitors Targeting Bacterial Seryl-tRNA Synthetase. J.Med.Chem., 62:9703-9717, 2019 Cited by PubMed: 31626547DOI: 10.1021/acs.jmedchem.9b01131 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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