6R1O

Crystal structure of E. coli seryl-tRNA synthetase complexed to a seryl sulfamoyl adenosine derivative

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004828	molecular_function	serine-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006412	biological_process	translation
A	0006418	biological_process	tRNA aminoacylation for protein translation
A	0006434	biological_process	seryl-tRNA aminoacylation
A	0016260	biological_process	selenocysteine biosynthetic process
A	0042802	molecular_function	identical protein binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	binding site for residue JPE A 501

Chain	Residue
A	THR237
A	LYS289
A	GLU291
A	GLU355
A	ILE356
A	SER357
A	SER358
A	ASN389
A	SER391
A	ALA394
A	GLY396
A	GLU239
A	ARG397
A	EDO513
A	ARG268
A	GLU270
A	LEU281
A	ILE282
A	ARG283
A	MET284
A	PHE287

---

site_id	AC2
Number of Residues	9
Details	binding site for residue JPE A 502

Chain	Residue
A	LYS166
A	SER191
A	ASN193
A	LEU245
A	GLU249
A	ASP255
A	ILE258
A	JPE503
A	HOH657

---

site_id	AC3
Number of Residues	12
Details	binding site for residue JPE A 503

Chain	Residue
A	GLU131
A	PHE132
A	ASP133
A	PHE134
A	GLU135
A	VAL136
A	SER147
A	LYS166
A	GLU249
A	ILE250
A	ASP255
A	JPE502

---

site_id	AC4
Number of Residues	1
Details	binding site for residue CL A 504

Chain	Residue
A	ARG373

---

site_id	AC5
Number of Residues	1
Details	binding site for residue CL A 505

Chain	Residue
A	ARG221

---

site_id	AC6
Number of Residues	4
Details	binding site for residue SO4 A 506

Chain	Residue
A	SER53
A	ASN120
A	GLU122
A	HOH656

---

site_id	AC7
Number of Residues	4
Details	binding site for residue SO4 A 507

Chain	Residue
A	ARG354
A	ARG397
A	HOH603
A	HOH660

---

site_id	AC8
Number of Residues	2
Details	binding site for residue SO4 A 508

Chain	Residue
A	ARG324
A	THR352

---

site_id	AC9
Number of Residues	3
Details	binding site for residue DMS A 509

Chain	Residue
A	GLY127
A	THR128
A	EDO514

---

site_id	AD1
Number of Residues	2
Details	binding site for residue DMS A 510

Chain	Residue
A	GLN187
A	TYR422

---

site_id	AD2
Number of Residues	5
Details	binding site for residue DMS A 511

Chain	Residue
A	ARG130
A	TYR406
A	GLN408
A	GLU414
A	EDO514

---

site_id	AD3
Number of Residues	4
Details	binding site for residue DMS A 512

Chain	Residue
A	GLN168
A	ARG171
A	MET423
A	LEU426

---

site_id	AD4
Number of Residues	8
Details	binding site for residue EDO A 513

Chain	Residue
A	VAL163
A	MET165
A	HIS173
A	LEU281
A	PHE287
A	ASP288
A	GLY396
A	JPE501

---

site_id	AD5
Number of Residues	5
Details	binding site for residue EDO A 514

Chain	Residue
A	GLY320
A	ASN405
A	TYR406
A	DMS509
A	DMS511

---

site_id	AD6
Number of Residues	4
Details	binding site for residue EDO A 515

Chain	Residue
A	PRO4
A	LEU7
A	ARG8
A	GLU34

---

site_id	AD7
Number of Residues	5
Details	binding site for residue EDO A 516

Chain	Residue
A	ASN200
A	GLN201
A	THR229
A	ASN231
A	HOH682

---

site_id	AD8
Number of Residues	2
Details	binding site for residue EDO A 517

Chain	Residue
A	HIS188
A	LYS314

---

site_id	AD9
Number of Residues	5
Details	binding site for residue TRS A 518

Chain	Residue
A	PRO421
A	PRO421
A	TYR422
A	TYR422
A	HOH604

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	THR237
A	ARG268
A	GLU291
A	GLU355
A	SER391

---