5FON
Crystal structure of the Cryptosporidium muris cytosolic leucyl-tRNA synthetase editing domain (apo structure)
Summary for 5FON
Entry DOI | 10.2210/pdb5fon/pdb |
Related | 5FO4 5FOC 5FOD 5FOF 5FOG 5FOL 5FOM |
Descriptor | LEUCYL-TRNA SYNTHETASE (3 entities in total) |
Functional Keywords | ligase, cryptosporidium, leucine-trna ligase (leurs) activity, atp + l-leucine + trna(leucine) give amp + diphosphate + l-leucyl-trna(leucine), post-transfer editing activity of leurs, aminoacyl-trna synthetase, protein biosynthesis, novel boron inhibitors of the editing site of leurs |
Biological source | CRYPTOSPORIDIUM MURIS More |
Total number of polymer chains | 4 |
Total formula weight | 131678.93 |
Authors | Palencia, A.,Liu, R.J.,Lukarska, M.,Gut, J.,Bougdour, A.,Touquet, B.,Wang, E.D.,Alley, M.R.K.,Rosenthal, P.J.,Hakimi, M.A.,Cusack, S. (deposition date: 2015-11-24, release date: 2016-08-03, Last modification date: 2024-01-10) |
Primary citation | Palencia, A.,Liu, R.,Lukarska, M.,Gut, J.,Bougdour, A.,Touquet, B.,Wang, E.,Li, X.,Alley, M.R.K.,Freund, Y.R.,Rosenthal, P.J.,Hakimi, M.,Cusack, S. Cryptosporidium and Toxoplasma Parasites are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase. Antimicrob.Agents Chemother., 60:5817-, 2016 Cited by PubMed: 27431220DOI: 10.1128/AAC.00873-16 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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