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4MVL
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Crystal structure of an engineered lipocalin (Anticalin H1GA) in complex with the Alzheimer amyloid peptide Abeta1-40
Descriptor: Beta-amyloid protein 40, Neutrophil gelatinase-associated lipocalin
Authors:Eichinger, A, Skerra, A.
Deposit date:2013-09-24
Release date:2015-08-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide.
Biochem.J., 473, 2016
4MNC
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Crystal structure of a TRAP periplasmic solute binding protein from Polaromonas sp. JS666 (Bpro_4736), Target EFI-510156, with bound benzoyl formate, space group P21
Descriptor: BENZOYL-FORMIC ACID, SULFATE ION, TRAP dicarboxylate transporter-DctP subunit
Authors:Vetting, M.W, Toro, R, Bhosle, R, Al Obaidi, N.F, Morisco, L.L, Wasserman, S.R, Sojitra, S, Zhao, S, Stead, M, Scott Glenn, A, Chowdhury, S, Evans, B, Hillerich, B, Love, J, Seidel, R.D, Imker, H.J, Jacobson, M.P, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI)
Deposit date:2013-09-10
Release date:2013-09-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Experimental strategies for functional annotation and metabolism discovery: targeted screening of solute binding proteins and unbiased panning of metabolomes.
Biochemistry, 54, 2015
1HQ8
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CRYSTAL STRUCTURE OF THE MURINE NK CELL-ACTIVATING RECEPTOR NKG2D AT 1.95 A
Descriptor: NKG2-D
Authors:Wolan, D.W, Teyton, L, Rudolph, M.G, Villmow, B, Bauer, S, Busch, D.H, Wilson, I.A.
Deposit date:2000-12-14
Release date:2001-03-07
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A.
Nat.Immunol., 2, 2001
1HII
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COMPARATIVE ANALYSIS OF THE X-RAY STRUCTURES OF HIV-1 AND HIV-2 PROTEASES IN COMPLEX WITH CGP 53820, A NOVEL PSEUDOSYMMETRIC INHIBITOR
Descriptor: ACETYL-NH-VAL-CYCLOHEXYL-CH2[NCH2CHOH]CH2-BENZYL-VAL-NH-ACETYL, HIV-2 PROTEASE, SULFATE ION
Authors:Priestle, J.P, Gruetter, M.G.
Deposit date:1995-03-31
Release date:1995-07-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Comparative analysis of the X-ray structures of HIV-1 and HIV-2 proteases in complex with CGP 53820, a novel pseudosymmetric inhibitor.
Structure, 3, 1995
1HLU
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STRUCTURE OF BOVINE BETA-ACTIN-PROFILIN COMPLEX WITH ACTIN BOUND ATP PHOSPHATES SOLVENT ACCESSIBLE
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, BETA-ACTIN, CALCIUM ION, ...
Authors:Chik, J.K, Lindberg, U, Schutt, C.E.
Deposit date:1997-05-30
Release date:1997-10-15
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:The structure of an open state of beta-actin at 2.65 A resolution.
J.Mol.Biol., 263, 1996
5JPH
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BU of 5jph by Molmil
Structure of a GNAT acetyltransferase SACOL1063 from Staphylococcus aureus in complex with CoA
Descriptor: Acetyltransferase SACOL1063, CHLORIDE ION, COENZYME A
Authors:Majorek, K.A, Osinski, T, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2016-05-03
Release date:2016-06-29
Last modified:2022-04-13
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Insight into the 3D structure and substrate specificity of previously uncharacterized GNAT superfamily acetyltransferases from pathogenic bacteria.
Biochim.Biophys.Acta, 1865, 2016
4MLR
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BU of 4mlr by Molmil
dihydrodipicolinate synthase from C. jejuni, Y110F mutation with pyruvate and Lysine
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, GLYCEROL, ...
Authors:Conly, C.J.T.
Deposit date:2013-09-06
Release date:2015-01-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Tyrosine 110 Plays a Critical Role in Regulating the Allosteric Inhibition of Campylobacter jejuni Dihydrodipicolinate Synthase by Lysine.
Biochemistry, 53, 2014
1HWH
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BU of 1hwh by Molmil
1:1 COMPLEX OF HUMAN GROWTH HORMONE MUTANT G120R WITH ITS SOLUBLE BINDING PROTEIN
Descriptor: GROWTH HORMONE, GROWTH HORMONE BINDING PROTEIN
Authors:Sundstrom, S.M, Lundqvist, T.
Deposit date:1996-11-13
Release date:1997-11-19
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 A resolution.
J.Biol.Chem., 271, 1996
1HNF
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR REGION OF THE HUMAN CELL ADHESION MOLECULE CD2 AT 2.5 ANGSTROMS RESOLUTION
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CD2, SODIUM ION
Authors:Bodian, D.L, Jones, E.Y, Harlos, K, Stuart, D.I, Davis, S.J.
Deposit date:1994-08-10
Release date:1995-02-07
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the extracellular region of the human cell adhesion molecule CD2 at 2.5 A resolution.
Structure, 2, 1994
7U9J
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Crystal structure of Mesothelin-207 fragment
Descriptor: GLYCEROL, Isoform 3 of Mesothelin, SULFATE ION
Authors:Zhan, J, Esser, L, Lin, D, Tang, W.K, Xia, D.
Deposit date:2022-03-10
Release date:2023-02-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies.
Cancer Res Commun, 3, 2023
1HSI
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BU of 1hsi by Molmil
CRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES
Descriptor: HIV-2 PROTEASE
Authors:Chen, Z.
Deposit date:1995-03-31
Release date:1996-04-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases.
J.Biol.Chem., 269, 1994
7UED
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BU of 7ued by Molmil
Crystal structure of full length mesothelin bound with MORAb-009 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Isoform 4 of Mesothelin, ...
Authors:Zhan, J, Esser, L, Lin, D, Tang, W.K, Xia, D.
Deposit date:2022-03-21
Release date:2023-02-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies.
Cancer Res Commun, 3, 2023
5JVG
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BU of 5jvg by Molmil
The large ribosomal subunit from Deinococcus radiodurans in complex with avilamycin
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 23S ribosomal RNA, 50S ribosomal protein L11, ...
Authors:Krupkin, M, Wekselman, I, Matzov, D, Eyal, Z, Diskin Posner, Y, Rozenberg, H, Zimmerman, E, Bashan, A, Yonath, A.
Deposit date:2016-05-11
Release date:2016-11-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.428 Å)
Cite:Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding.
Proc.Natl.Acad.Sci.USA, 113, 2016
1HXW
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BU of 1hxw by Molmil
HIV-1 PROTEASE DIMER COMPLEXED WITH A-84538
Descriptor: HIV-1 PROTEASE, RITONAVIR
Authors:Park, C.H, Nienaber, V, Kong, X.P.
Deposit date:1997-01-24
Release date:1998-02-04
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans.
Proc.Natl.Acad.Sci.USA, 92, 1995
1HUH
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BU of 1huh by Molmil
DIFFERENCES IN ANIONIC INHIBITION OF HUMAN CARBONIC ANHYDRASE I REVEALED FROM THE STRUCTURES OF IODIDE AND GOLD CYANIDE INHIBITOR COMPLEXES
Descriptor: CARBONIC ANHYDRASE I, IODIDE ION, ZINC ION
Authors:Kumar, V, Kannan, K.K.
Deposit date:1993-10-28
Release date:1994-04-30
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Differences in anionic inhibition of human carbonic anhydrase I revealed from the structures of iodide and gold cyanide inhibitor complexes.
Acta Crystallogr.,Sect.D, 50, 1994
4N4K
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BU of 4n4k by Molmil
Kuenenia stuttgartiensis hydroxylamine oxidoreductase soaked in hydroxylamine
Descriptor: 1,2-ETHANEDIOL, HEME C, HYDROXYAMINE, ...
Authors:Maalcke, W.J, Dietl, A, Marritt, S.J, Butt, J.N, Jetten, M.S.M, Keltjens, J.T, Barends, T.R.M.B, Kartal, B.
Deposit date:2013-10-08
Release date:2013-12-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis of Biological NO Generation by Octaheme Oxidoreductases.
J.Biol.Chem., 289, 2014
1HQX
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BU of 1hqx by Molmil
R308K ARGINASE VARIANT
Descriptor: ARGINASE, MANGANESE (II) ION
Authors:Lavulo, L.T, Sossong Jr, T.M, Brigham-Burke, M.R, Doyle, M.L, Cox, J.D, Christianson, D.W, Ash, D.E.
Deposit date:2000-12-20
Release date:2001-06-06
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:Subunit-subunit interactions in trimeric arginase. Generation of active monomers by mutation of a single amino acid.
J.Biol.Chem., 276, 2001
1HJN
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BU of 1hjn by Molmil
HUMAN PRION PROTEIN AT PH 7.0
Descriptor: MAJOR PRION PROTEIN PRECURSOR
Authors:Calzolai, L, Zahn, R.
Deposit date:2003-02-27
Release date:2003-07-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Influence of Ph on NMR Structure and Stability of the Human Prion Protein Globular Domain
J.Biol.Chem., 278, 2003
7UUJ
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Crystal structure of aminoglycoside resistance enzyme ApmA, complex with gentamicin
Descriptor: (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL, 1,2-ETHANEDIOL, Aminocyclitol acetyltransferase ApmA, ...
Authors:Stogios, P.J, Evdokimova, E, Osipiuk, J, Di Leo, R, Bordeleau, E, Wright, G.D, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID)
Deposit date:2022-04-28
Release date:2023-04-19
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Crystal structure of aminoglycoside resistance enzyme ApmA, complex with gentamicin
To Be Published
4MMK
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Q8A Hfq from Pseudomonas aeruginosa
Descriptor: POTASSIUM ION, Protein hfq, SODIUM ION, ...
Authors:Murina, V.N, Filimonov, V.V, Melnik, B.S, Uhlein, M, Mueller, U, Weiss, M, Nikulin, A.D.
Deposit date:2013-09-09
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.156 Å)
Cite:Effect of conserved intersubunit amino Acid substitutions on hfq protein structure and stability.
Biochemistry Mosc., 79, 2014
1HUG
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BU of 1hug by Molmil
Differences in anionic inhibition of Human Carbonic Anhydrase I revealed from the structures of iodide and gold cyanide inhibitor complexes
Descriptor: CARBONIC ANHYDRASE I, GOLD (I) CYANIDE ION, ZINC ION
Authors:Kumar, V, Kannan, K.K.
Deposit date:1993-10-28
Release date:1994-04-30
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Differences in anionic inhibition of human carbonic anhydrase I revealed from the structures of iodide and gold cyanide inhibitor complexes.
Acta Crystallogr.,Sect.D, 50, 1994
1HIH
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COMPARATIVE ANALYSIS OF THE X-RAY STRUCTURES OF HIV-1 AND HIV-2 PROTEASES IN COMPLEX WITH CGP 53820, A NOVEL PSEUDOSYMMETRIC INHIBITOR
Descriptor: ACETYL-NH-VAL-CYCLOHEXYL-CH2[NCH2CHOH]CH2-BENZYL-VAL-NH-ACETYL, BETA-MERCAPTOETHANOL, HIV-1 PROTEASE
Authors:Priestle, J.P, Gruetter, M.G.
Deposit date:1995-03-31
Release date:1995-07-10
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Comparative analysis of the X-ray structures of HIV-1 and HIV-2 proteases in complex with CGP 53820, a novel pseudosymmetric inhibitor.
Structure, 3, 1995
4MVI
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Crystal structure of an engineered lipocalin (Anticalin US7) in complex with the Alzheimer amyloid peptide Abeta(1-40)
Descriptor: Beta-amyloid protein 40, Neutrophil gelatinase-associated lipocalin
Authors:Eichinger, A, Skerra, A.
Deposit date:2013-09-24
Release date:2015-08-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide.
Biochem.J., 473, 2016
4MY5
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BU of 4my5 by Molmil
Crystal structure of the aromatic amino acid aminotransferase from Streptococcus mutants
Descriptor: Putative amino acid aminotransferase
Authors:Cong, X, Li, X, Ge, J, Feng, Y, Feng, X, Li, S.
Deposit date:2013-09-27
Release date:2014-10-01
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.194 Å)
Cite:Crystal structure of the aromatic-amino-acid aminotransferase from Streptococcus mutans.
Acta Crystallogr.,Sect.F, 75, 2019
5JS2
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Human Argonaute-2 Bound to a Modified siRNA
Descriptor: MAGNESIUM ION, PHENOL, PHOSPHATE ION, ...
Authors:Schirle, N.T, MacRae, I.J.
Deposit date:2016-05-07
Release date:2016-07-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.954 Å)
Cite:Structural Analysis of Human Argonaute-2 Bound to a Modified siRNA Guide.
J.Am.Chem.Soc., 138, 2016

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