7UUJ

Crystal structure of aminoglycoside resistance enzyme ApmA, complex with gentamicin

Summary for 7UUJ

Entry DOI	10.2210/pdb7uuj/pdb
Related	7UUK 7UUL 7UUM 7UUN 7UUO
Descriptor	Aminocyclitol acetyltransferase ApmA, (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	xat, xenobiotic acetyltransferase, left-handed beta helix, lbh, antibiotic resistance, aminoglycoside, structural genomics, csgid, center for structural genomics of infectious diseases, niaid, national institute of allergy and infectious diseases, transferase, center for structural biology of infectious diseases, csbid
Biological source	Staphylococcus aureus
Total number of polymer chains	3
Total formula weight	95653.92
Authors	Stogios, P.J.,Evdokimova, E.,Osipiuk, J.,Di Leo, R.,Bordeleau, E.,Wright, G.D.,Savchenko, A.,Joachimiak, A.,Satchell, K.J.F.,Center for Structural Biology of Infectious Diseases (CSBID) (deposition date: 2022-04-28, release date: 2023-04-19, Last modification date: 2026-02-25)
Primary citation	Bordeleau, E.,Stogios, P.J.,Evdokimova, E.,Koteva, K.,Savchenko, A.,Wright, G.D. Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance Nat.Chem.Biol., 20:234-242, 2024 Cited by DOI: 10.1038/s41589-023-01483-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.78 Å)

Structure validation