7UUO

Crystal structure of aminoglycoside resistance enzyme ApmA H135A mutant, complex with tobramycin and coenzyme A

Summary for 7UUO

Entry DOI	10.2210/pdb7uuo/pdb
Related	7UUJ 7UUK 7UUL 7UUM 7UUN
Descriptor	Aminocyclitol acetyltransferase ApmA, TOBRAMYCIN, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	xat, xenobiotic acetyltransferase, left-handed beta helix, lbh, antibiotic resistance, aminoglycoside, structural genomics, csgid, center for structural genomics of infectious diseases, niaid, national institute of allergy and infectious diseases, transferase
Biological source	Staphylococcus aureus
Total number of polymer chains	3
Total formula weight	96003.91
Authors	Stogios, P.J.,Evdokimova, E.,Michalska, K.,Di Leo, R.,Bordeleau, E.,Wright, G.D.,Savchenko, A.,Joachimiak, A.,Satchell, K.J.F.,Center for Structural Genomics of Infectious Diseases (CSGID),Center for Structural Biology of Infectious Diseases (CSBID) (deposition date: 2022-04-28, release date: 2022-11-02, Last modification date: 2024-02-14)
Primary citation	Bordeleau, E.,Stogios, P.J.,Evdokimova, E.,Koteva, K.,Savchenko, A.,Wright, G.D. Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance. Nat.Chem.Biol., 20:234-242, 2024 Cited by PubMed: 37973888 DOI: 10.1038/s41589-023-01483-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.65 Å)

Structure validation