2IRF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2irf by Molmil](/molmil-images/mine/2irf) | CRYSTAL STRUCTURE OF AN IRF-2/DNA COMPLEX. | Descriptor: | DNA (5'-D(*TP*TP*CP*AP*CP*TP*TP*TP*CP*AP*CP*(5IU)P*T)-3'), DNA (5'-D(P*AP*AP*GP*TP*GP*AP*AP*AP*GP*(5IU)P*GP*A)-3'), INTERFERON REGULATORY FACTOR 2, ... | Authors: | Fujii, Y, Shimizu, T, Kusumoto, M, Kyogoku, Y, Taniguchi, T, Hakoshima, T. | Deposit date: | 1999-05-30 | Release date: | 1999-10-08 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of an IRF-DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences. EMBO J., 18, 1999
|
|
7OGS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ogs by Molmil](/molmil-images/mine/7ogs) | |
7OOT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7oot by Molmil](/molmil-images/mine/7oot) | X-ray Structure of Interferon Regulatory Factor 4 DNA binding domain bound to an interferon-stimulated response element | Descriptor: | DNA (5'-D(P*AP*GP*CP*TP*TP*TP*CP*TP*CP*GP*GP*TP*TP*TP*CP*AP*GP*TP*TP*G)-3'), DNA (5'-D(P*TP*CP*AP*AP*CP*TP*GP*AP*AP*AP*CP*CP*GP*AP*GP*AP*AP*AP*GP*C)-3'), Interferon regulatory factor 4, ... | Authors: | Agnarelli, A, El Omari, K, Alt, A.O, Mancini, E.J. | Deposit date: | 2021-05-28 | Release date: | 2022-06-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | X-ray Structure of Interferon Regulatory Factor 4 DNA binding domain bound to interferon-stimulated response element To Be Published
|
|
7RH2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7rh2 by Molmil](/molmil-images/mine/7rh2) | IRF4 Transcription factor mutant -K59R | Descriptor: | DNA (5'-D(*CP*AP*AP*CP*TP*GP*AP*AP*AP*CP*CP*GP*AP*GP*AP*AP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*TP*TP*CP*TP*CP*GP*GP*TP*TP*TP*CP*AP*GP*TP*TP*G)-3'), ICSAT transcription factor | Authors: | Williams, S.J, Sundararaj, S, Casarotto, M.G. | Deposit date: | 2021-07-16 | Release date: | 2022-05-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.47 Å) | Cite: | The molecular basis for the development of adult T-cell leukemia/lymphoma in patients with an IRF4 K59R mutation. Protein Sci., 31, 2022
|
|
7JM4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7jm4 by Molmil](/molmil-images/mine/7jm4) | IRF Transcription Factor | Descriptor: | Interferon regulatory factor 4, Interferon-Stimulated Response Elements | Authors: | Sundararaj, S, Williams, S.J, Casarotto, M.G. | Deposit date: | 2020-07-31 | Release date: | 2021-03-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Structural determinants of the IRF4/DNA homodimeric complex. Nucleic Acids Res., 49, 2021
|
|
7O56
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7o56 by Molmil](/molmil-images/mine/7o56) | X-ray Structure of Interferon Regulatory Factor 4 DNA binding domain bound to an interferon-stimulated response element solved by Phosphorus and Sulphur SAD methods | Descriptor: | DNA (5'-D(P*AP*AP*TP*AP*AP*AP*AP*GP*AP*AP*AP*CP*CP*GP*AP*AP*AP*GP*TP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*AP*CP*TP*TP*TP*CP*GP*GP*TP*TP*TP*CP*TP*TP*TP*TP*AP*T)-3'), Interferon regulatory factor 4 | Authors: | El Omari, K, Agnarelli, A, Duman, R, Wagner, A, Mancini, E.J. | Deposit date: | 2021-04-07 | Release date: | 2021-05-12 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Phosphorus and sulfur SAD phasing of the nucleic acid-bound DNA-binding domain of interferon regulatory factor 4. Acta Crystallogr.,Sect.F, 77, 2021
|
|
6TD4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6td4 by Molmil](/molmil-images/mine/6td4) | IRF4 DNA-binding domain surface entropy mutant apo structure | Descriptor: | CHLORIDE ION, Interferon regulatory factor 4 | Authors: | Tucker, J.A, Martin, M.P, Wang, L.Z, Jennings, C, Heath, R. | Deposit date: | 2019-11-07 | Release date: | 2020-11-18 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Cancer-associated mutations in the IRF4 DNA-binding domain confer no disadvantage in DNA-binding affinity and may increase transcriptional activity To Be Published
|
|
2O6G
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2o6g by Molmil](/molmil-images/mine/2o6g) | |
2DLL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2dll by Molmil](/molmil-images/mine/2dll) | Solution structure of the IRF domain of human interferon regulator factors 4 | Descriptor: | Interferon regulatory factor 4 | Authors: | Zhang, H.P, Kurosaki, C, Yoshida, M, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2006-04-20 | Release date: | 2006-10-20 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the IRF domain of human interferon regulator factors 4 To be published
|
|
2PI0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2pi0 by Molmil](/molmil-images/mine/2pi0) | Crystal Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-B enhancer | Descriptor: | Interferon regulatory factor 3, PRDIII-I region of human interferon-B promoter strand 1, PRDIII-I region of human interferon-B promoter strand 2 | Authors: | Escalante, C.R, Nistal-Villan, E, Leyi, S, Garcia-Sastre, A, Aggarwal, A.K. | Deposit date: | 2007-04-12 | Release date: | 2007-10-30 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-beta enhancer. Mol.Cell, 26, 2007
|
|
3QU3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3qu3 by Molmil](/molmil-images/mine/3qu3) | Crystal structure of IRF-7 DBD apo form | Descriptor: | 1,2-ETHANEDIOL, Interferon regulatory factor 7, SODIUM ION | Authors: | De Ioannes, P.E, Escalante, C.R, Aggarwal, A.K. | Deposit date: | 2011-02-23 | Release date: | 2011-06-01 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structures of apo IRF-3 and IRF-7 DNA binding domains: effect of loop L1 on DNA binding. Nucleic Acids Res., 39, 2011
|
|
3QU6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3qu6 by Molmil](/molmil-images/mine/3qu6) | Crystal structure of IRF-3 DBD free form | Descriptor: | CHLORIDE ION, IRF3 protein, SODIUM ION, ... | Authors: | De Ioannes, P.E, Escalante, C.R, Aggarwal, A.K. | Deposit date: | 2011-02-23 | Release date: | 2011-06-01 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structures of apo IRF-3 and IRF-7 DNA binding domains: effect of loop L1 on DNA binding. Nucleic Acids Res., 39, 2011
|
|
4HLY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4hly by Molmil](/molmil-images/mine/4hly) | |
4HLX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4hlx by Molmil](/molmil-images/mine/4hlx) | |
8HCM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8hcm by Molmil](/molmil-images/mine/8hcm) | zebrafish IRF-11 DBD complex with DNA | Descriptor: | DNA (5'-D(P*GP*CP*TP*TP*TP*CP*AP*CP*TP*TP*TP*CP*TP*A)-3'), DNA (5'-D(P*TP*AP*GP*AP*AP*AP*GP*TP*GP*AP*AP*AP*GP*C)-3'), Interferon regulatory factor | Authors: | Wang, Z.X, Zhang, Y.A, Ouyang, S.Y. | Deposit date: | 2022-11-02 | Release date: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Structure of Danio rerio IRF10 and IRF11 bound DNA reveal determinants of interferon regulation To Be Published
|
|
8HCL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8hcl by Molmil](/molmil-images/mine/8hcl) | zebrafish IRF-10 DBD complex with DNA | Descriptor: | DNA (5'-D(P*AP*CP*TP*TP*TP*CP*AP*CP*TP*TP*CP*A)-3'), DNA (5'-D(P*TP*GP*AP*AP*GP*TP*GP*AP*AP*AP*GP*T)-3'), Interferon regulatory factor 10 | Authors: | Wang, Z.X, Zhang, Y.A, Ouyang, S.Y. | Deposit date: | 2022-11-01 | Release date: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Structure of Danio rerio IRF10 and IRF11 bound DNA reveal determinants of interferon regulation To Be Published
|
|
8HCS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8hcs by Molmil](/molmil-images/mine/8hcs) | zebrafish IRF-11 DBD | Descriptor: | Interferon regulatory factor | Authors: | Wang, Z.X, Zhang, Y.A, Ouyang, S.Y. | Deposit date: | 2022-11-03 | Release date: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structure of Danio rerio IRF10 and IRF11 bound DNA reveal determinants of interferon regulation To Be Published
|
|
1IRG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1irg by Molmil](/molmil-images/mine/1irg) | INTERFERON REGULATORY FACTOR-2 DNA BINDING DOMAIN, NMR, 20 STRUCTURES | Descriptor: | INTERFERON REGULATORY FACTOR-2 | Authors: | Furui, J, Uegaki, K, Yamazaki, T, Shirakawa, M, Swindells, M.B, Harada, H, Taniguchi, T, Kyogoku, Y. | Deposit date: | 1997-11-25 | Release date: | 1998-03-18 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution structure of the IRF-2 DNA-binding domain: a novel subgroup of the winged helix-turn-helix family. Structure, 6, 1998
|
|
1IF1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1if1 by Molmil](/molmil-images/mine/1if1) | INTERFERON REGULATORY FACTOR 1 (IRF-1) COMPLEX WITH DNA | Descriptor: | DNA (26-MER), PROTEIN (INTERFERON REGULATORY FACTOR 1) | Authors: | Escalante, C.R, Yie, J, Thanos, D, Aggarwal, A. | Deposit date: | 1997-09-12 | Release date: | 1998-02-25 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure of IRF-1 with bound DNA reveals determinants of interferon regulation. Nature, 391, 1998
|
|
1IRF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1irf by Molmil](/molmil-images/mine/1irf) | INTERFERON REGULATORY FACTOR-2 DNA BINDING DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE | Descriptor: | INTERFERON REGULATORY FACTOR-2 | Authors: | Furui, J, Uegaki, K, Yamazaki, T, Shirakawa, M, Swindells, M.B, Harada, H, Taniguchi, T, Kyogoku, Y. | Deposit date: | 1997-11-24 | Release date: | 1998-01-28 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution structure of the IRF-2 DNA-binding domain: a novel subgroup of the winged helix-turn-helix family. Structure, 6, 1998
|
|
8JKS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jks by Molmil](/molmil-images/mine/8jks) | |
8JKL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jkl by Molmil](/molmil-images/mine/8jkl) | IRF4 DNA-binding domain bound to an DNA containing GATA motif | Descriptor: | GATA-Forward, GATA-Reverse, Interferon regulatory factor 4 | Authors: | Wang, G, Feng, X, Ding, J. | Deposit date: | 2023-06-01 | Release date: | 2023-09-20 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.94 Å) | Cite: | Molecular basis for the functional roles of the multimorphic T95R mutation of IRF4 causing human autosomal dominant combined immunodeficiency. Structure, 31, 2023
|
|
8JKQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jkq by Molmil](/molmil-images/mine/8jkq) | |
8JKN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jkn by Molmil](/molmil-images/mine/8jkn) | |
8JKO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jko by Molmil](/molmil-images/mine/8jko) | |