8JKO
T95R mutant IRF4 DNA-binding domain bound to an DNA containing GATA motif
Summary for 8JKO
Entry DOI | 10.2210/pdb8jko/pdb |
Descriptor | GATA-Forward, GATA-Reverse, Interferon regulatory factor 4 (3 entities in total) |
Functional Keywords | irf4, transcription factor, protein-dna complex, transcription |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 8 |
Total formula weight | 77885.10 |
Authors | |
Primary citation | Wang, G.,Feng, X.,Ding, J. Molecular basis for the functional roles of the multimorphic T95R mutation of IRF4 causing human autosomal dominant combined immunodeficiency. Structure, 31:1441-, 2023 Cited by PubMed: 37683642DOI: 10.1016/j.str.2023.08.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.95 Å) |
Structure validation
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