7RH2

IRF4 Transcription factor mutant -K59R

Summary for 7RH2

• Entry DOI: 10.2210/pdb7rh2/pdb
• Descriptor: ICSAT transcription factor, DNA (5'-D(*CP*AP*AP*CP*TP*GP*AP*AP*AP*CP*CP*GP*AP*GP*AP*AP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*TP*TP*CP*TP*CP*GP*GP*TP*TP*TP*CP*AP*GP*TP*TP*G)-3'), ... (4 entities in total)
• Functional Keywords: irf4, cancer, homodimer complex, protein/dna interaction, transcription factor, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 75830.49

Authors

Williams, S.J.,Sundararaj, S.,Casarotto, M.G. (deposition date: 2021-07-16, release date: 2022-05-25, Last modification date: 2023-10-18)

• Primary citation: Sundararaj, S.,Seneviratne, S.,Williams, S.J.,Enders, A.,Casarotto, M.G.; The molecular basis for the development of adult T-cell leukemia/lymphoma in patients with an IRF4 K59R mutation.; Protein Sci., 31:787-796, 2022; PubMed: 34913532; DOI: 10.1002/pro.4260

Experimental method

X-RAY DIFFRACTION (2.47 Å)