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PDB: 224 results

6CO3
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aducanumab abeta complex
Descriptor: ALA-GLU-PHE-ARG-HIS-ASP, Fab heavy chain, Fab light chain, ...
Authors:Arndt, J.W.
Deposit date:2018-03-10
Release date:2018-05-02
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.384 Å)
Cite:Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-beta.
Sci Rep, 8, 2018
7E6P
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Fab-amyloid beta fragment complex
Descriptor: 1,2-ETHANEDIOL, Amyloid beta fragment with an intramolecular disulfide bond at positions 17 and 28, DI(HYDROXYETHYL)ETHER, ...
Authors:Kita, A, Irie, K, Irie, Y, Miki, K.
Deposit date:2021-02-23
Release date:2022-01-05
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Characterization of a Conformation-Restricted Amyloid beta Peptide and Immunoreactivity of Its Antibody in Human AD brain.
Acs Chem Neurosci, 12, 2021
5HOW
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X-ray crystallographic structure of an Abeta 17-36 beta-hairpin. LV(PHI)FAEDCGSNKCAII(SAR)L(ORN)V
Descriptor: Amyloid beta A4 protein
Authors:Kreutzer, A.G, Nowick, J.S, Spencer, R.K.
Deposit date:2016-01-19
Release date:2016-03-23
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.295 Å)
Cite:X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an A beta 17-36 beta-Hairpin.
J.Am.Chem.Soc., 138, 2016
7WFY
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Crystal Structure of the VAV2 SH2 domain in complex with APP phosphorylated peptide
Descriptor: Amyloid beta A4 protein-binding family B member 1 (protein), Guanine nucleotide exchange factor VAV2
Authors:Zhang, Y.J, Liu, Y.R, Wu, B.
Deposit date:2021-12-27
Release date:2022-12-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.449 Å)
Cite:Vav2 is a novel APP-interacting protein that regulates APP protein level.
Sci Rep, 12, 2022
8H8Q
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Fab-amyloid beta fragment complex at neutral pH
Descriptor: CHLORIDE ION, Fab, GLN-LYS-CYS-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-CYS-GLY, ...
Authors:Kita, A, Irie, K, Irie, Y, Matsushima, Y, Miki, K.
Deposit date:2022-10-24
Release date:2023-10-25
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Fab-amyloid beta fragment complex at neutral pH
To Be Published
8I4O
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Design of a split green fluorescent protein for sensing and tracking an beta-amyloid
Descriptor: Beta-amyloid, Split Green flourescent protein
Authors:Taegeun, Y, Jinsu, L, Jungmin, Y, Jungmin, C, Wondo, H, Song, J.J, Haksung, K.
Deposit date:2023-01-20
Release date:2023-11-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Engineering of a Fluorescent Protein for a Sensing of an Intrinsically Disordered Protein through Transition in the Chromophore State.
Jacs Au, 3, 2023
7Y3J
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24B3 antibody-peptide complex
Descriptor: 24B3 Heavy chain, 24B3 Light chain, ALA-LEU-VAL-PHE-PHE-ALA-PRO-ALA-VAL-GLY-SER
Authors:Irie, K, Irie, Y, Kita, A, Miki, K.
Deposit date:2022-06-11
Release date:2022-08-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis of the 24B3 antibody against the toxic conformer of amyloid beta with a turn at positions 22 and 23.
Biochem.Biophys.Res.Commun., 621, 2022
8T82
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Racemic mixture of amyloid beta segment 35-MVGGVV-40 forms heterochiral rippled beta-sheet, includes pentafluoropropionic acid
Descriptor: amyloid beta segment 35-MVGGVV-40, racemic mixture, pentafluoropropanoic acid
Authors:Sawaya, M.R, Raskatov, J.A, Hazari, A.
Deposit date:2023-06-21
Release date:2023-11-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Racemic Peptides from Amyloid beta and Amylin Form Rippled beta-Sheets Rather Than Pleated beta-Sheets.
J.Am.Chem.Soc., 145, 2023
8T89
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Racemic mixture of amyloid beta segment 16-KLVFFA-21 forms heterochiral rippled beta-sheet
Descriptor: Racemic mixture of amyloid beta segment 16-KLVFFA-21, trifluoroacetic acid
Authors:Sawaya, M.R, Raskatov, J.A, Hazari, A.
Deposit date:2023-06-22
Release date:2023-11-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Racemic Peptides from Amyloid beta and Amylin Form Rippled beta-Sheets Rather Than Pleated beta-Sheets.
J.Am.Chem.Soc., 145, 2023
3JQL
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BU of 3jql by Molmil
Crystal Structure of the Complex Formed Between Phospholipase A2 and a Hexapeptide Fragment of Amyloid Beta Peptide, Lys-Leu-Val-Phe-Phe-Ala at 1.2 A Resolution
Descriptor: Acidic phospholipase A2 3 (Fragment), Amyloid Beta Peptide, CALCIUM ION
Authors:Mirza, Z, Vikram, G, Singh, N, Sinha, M, Sharma, S, Srinivasan, A, Kaur, P, Singh, T.P.
Deposit date:2009-09-07
Release date:2009-09-29
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Crystal Structure of the Complex Formed Between Phospholipase A2 and a Hexapeptide Fragment of Amyloid Beta Peptide, Lys-Leu-Val-Phe-Phe-Ala at 1.2 A Resolution
To be Published
3JQ5
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Phospholipase A2 Prevents the Aggregation of Amyloid Beta Peptides: Crystal Structure of the Complex of Phospholipase A2 with Octapeptide Fragment of Amyloid Beta Peptide, Asp-Ala-Glu-Phe-Arg-His-Asp-Ser at 2 A Resolution
Descriptor: Amyloid Beta Peptide, CALCIUM ION, Phospholipase A2 isoform 3
Authors:Mirza, Z, Vikram, G, Singh, N, Sinha, M, Bhushan, A, Sharma, S, Srinivasan, A, Kaur, P, Singh, T.P.
Deposit date:2009-09-06
Release date:2009-09-29
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Phospholipase A2 Prevents the Aggregation of Amyloid Beta Peptides: Crystal Structure of the Complex of Phospholipase A2 with Octapeptide Fragment of Amyloid Beta Peptide, Asp-Ala-Glu-Phe-Arg-His-Asp-Ser at 2 A Resolution
To be Published
5MY4
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BU of 5my4 by Molmil
Structure of Pyroglutamate-Abeta-specific Fab c#17 in complex with human Abeta-pE3-12PEGb
Descriptor: Fab c#17 heavy chain, Fab c#17 light chain, Pyroglutamate-Abeta pE3-12-PEGb
Authors:Parthier, C, Piechotta, A, Stubbs, M.T.
Deposit date:2017-01-25
Release date:2017-06-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.211 Å)
Cite:Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy.
J. Biol. Chem., 292, 2017
5ONP
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BU of 5onp by Molmil
Alzheimer's Amyloid-Beta Peptide Fragment 1-40 in Complex with Cd-substituted Thermolysin
Descriptor: Amyloid-beta A4 protein, CADMIUM ION, CALCIUM ION, ...
Authors:Leite, J.P, Gales, L.
Deposit date:2017-08-04
Release date:2018-08-29
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Alzheimer's A beta1-40peptide degradation by thermolysin: evidence of inhibition by a C-terminal A beta product.
FEBS Lett., 593, 2019
5MYX
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BU of 5myx by Molmil
Structure of Pyroglutamate-Abeta-specific Fab c#24 in complex with human Abeta-pE3-18
Descriptor: Fab c#24 heavy chain, Fab c#24 light chain, Pyroglutamate-Abeta pE3-18
Authors:Parthier, C, Piechotta, A, Stubbs, M.T.
Deposit date:2017-01-30
Release date:2017-06-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.492 Å)
Cite:Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy.
J. Biol. Chem., 292, 2017
5ONQ
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BU of 5onq by Molmil
Alzheimer's Amyloid-Beta Peptide Fragment 29-40 in Complex with Cd-substituted Thermolysin
Descriptor: Amyloid-beta A4 protein, CADMIUM ION, CALCIUM ION, ...
Authors:Leite, J.P, Gales, L.
Deposit date:2017-08-04
Release date:2018-08-29
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.17 Å)
Cite:Alzheimer's A beta1-40peptide degradation by thermolysin: evidence of inhibition by a C-terminal A beta product.
FEBS Lett., 593, 2019
2IPU
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BU of 2ipu by Molmil
PFA1 Fab fragment complexed with Abeta 1-8 peptide
Descriptor: ACETAMIDE, GLYCEROL, IgG2a Fab fragment Heavy Chain, ...
Authors:Gardberg, A.S, Dealwis, C.
Deposit date:2006-10-12
Release date:2007-10-09
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Molecular basis for passive immunotherapy of Alzheimer's disease
Proc.Natl.Acad.Sci.Usa, 104, 2007
7F29
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BU of 7f29 by Molmil
Cryo-EM structure of the fibril formed by disaccharide-modified amyloid-beta(1-42)
Descriptor: ACETIC ACID, Amyloid-beta A4 protein, beta-D-galactopyranose-(1-3)-2-amino-2-deoxy-alpha-D-galactopyranose
Authors:Xia, W.C, Sun, Y.P, Liu, C.
Deposit date:2021-06-10
Release date:2022-07-13
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:O-Glycosylation Induces Amyloid-beta To Form New Fibril Polymorphs Vulnerable for Degradation
J.Am.Chem.Soc., 143, 2021
6ITU
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BU of 6itu by Molmil
Crystal Structure of the GULP1 PTB domain-APP peptide complex
Descriptor: 1,2-ETHANEDIOL, Amyloid beta A4 protein, PTB domain-containing engulfment adapter protein 1, ...
Authors:Yung, K.W.Y, Lau, K.F, Ngo, J.C.K.
Deposit date:2018-11-26
Release date:2019-08-14
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Attenuation of amyloid-beta generation by atypical protein kinase C-mediated phosphorylation of engulfment adaptor PTB domain containing 1 threonine 35.
Faseb J., 33, 2019
5W3P
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BU of 5w3p by Molmil
ANTIBODY C706 IN COMPLEX WTH BETA-AMYLOID PEPTIDE 1-16
Descriptor: Amyloid beta A4 protein, Antibody C706 Fab HEAVY CHAIN, Antibody C706 Fab LIGHT CHAIN, ...
Authors:Teplyakov, A, Obmolova, G, Gilliland, G.L.
Deposit date:2017-06-08
Release date:2017-09-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:A coiled conformation of amyloid-beta recognized by antibody C706.
Alzheimers Res Ther, 9, 2017
5HOY
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BU of 5hoy by Molmil
X-ray crystallographic structure of an A-beta 17_36 beta-hairpin. X-ray diffractometer data set. (LVFFAEDCGSNKCAII(SAR)LMV).
Descriptor: Amyloid beta A4 protein, O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500)
Authors:Kreutzer, A.G, Spencer, R.K, Nowick, J.S.
Deposit date:2016-01-19
Release date:2016-03-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.295 Å)
Cite:X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an A beta 17-36 beta-Hairpin.
J.Am.Chem.Soc., 138, 2016
5VOS
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BU of 5vos by Molmil
VGSNKGAIIGL from Amyloid Beta determined by MicroED
Descriptor: Amyloid beta A4 protein
Authors:Rodriguez, J.A, Sawaya, M.R, Cascio, D, Eisenberg, D.S, Griner, S.L, Gonen, T.
Deposit date:2017-05-03
Release date:2018-01-03
Last modified:2024-03-13
Method:ELECTRON CRYSTALLOGRAPHY (1.42 Å)
Cite:Common fibrillar spines of amyloid-beta and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors.
J. Biol. Chem., 293, 2018
5LFY
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BU of 5lfy by Molmil
Zinc bound dimer of the fragment of human amyloid-beta peptide with Alzheimer's disease pathogenic Taiwanese mutation D7H
Descriptor: Amyloid beta A4 protein, ZINC ION
Authors:Polshakov, V.I, Mantsyzov, A.B, Kozin, S.A.
Deposit date:2016-07-05
Release date:2017-08-23
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:A Binuclear Zinc Interaction Fold Discovered in the Homodimer of Alzheimer's Amyloid-beta Fragment with Taiwanese Mutation D7H.
Angew. Chem. Int. Ed. Engl., 56, 2017
5HOX
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X-ray crystallographic structure of an A-beta 17_36 beta-hairpin. Synchrotron data set. (LVFFAEDCGSNKCAII(SAR)LMV).
Descriptor: Amyloid beta A4 protein, O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500)
Authors:Kreutzer, A.G, Nowick, J.S, Spencer, R.K.
Deposit date:2016-01-19
Release date:2016-03-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an A beta 17-36 beta-Hairpin.
J.Am.Chem.Soc., 138, 2016
5LV0
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BU of 5lv0 by Molmil
Structure of Human Neurolysin (E475Q) in complex with amyloid-beta 35-40 peptide product
Descriptor: CHLORIDE ION, GLY-VAL-VAL amyloid 35-40 fragment, Neurolysin, ...
Authors:Masuyer, G, Berntsson, R.P.-A, Teixeira, P.F, Kmiec, B, Glaser, E, Stenmark, P.
Deposit date:2016-09-12
Release date:2017-12-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and functional analysis of Neurolysin, a new component of the mitochondrial peptidolytic network
To Be Published
7WVY
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Cryo-EM structure of the human formyl peptide receptor 2 in complex with Abeta42 and Gi2
Descriptor: Amyloid-beta A4 protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B.
Deposit date:2022-02-11
Release date:2022-04-13
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022

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