PDB: 322 件ウェブページステータス検索Chemie searchBIRD

---

8RQC	Crystal structure of CRBN-midi in complex with mezigdomide and IKZF1 ZF2 分子名称: DNA-binding protein Ikaros, Mezigdomide, Protein cereblon, ... 著者 Furihata, H, Kroupova, A, Zollman, D, Ciulli, A. 登録日 2024-01-17 公開日 2024-09-25 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders To Be Published
8TLO	Crystal Structure Analysis of BCL11A in complex with DNA 分子名称: B-cell lymphoma/leukemia 11A, DNA (5'-D(P*CP*GP*AP*CP*CP*GP*CP*AP*TP*TP*GP*GP*TP*CP*AP*AP*GP*CP*G)-3'), DNA (5'-D(P*GP*CP*TP*TP*GP*AP*CP*CP*AP*AP*TP*GP*CP*GP*GP*TP*CP*GP*C)-3'), ... 著者 Seo, H.-S, Dhe-Paganon, S. 登録日 2023-07-27 公開日 2024-08-14 実験手法 X-RAY DIFFRACTION (2.76 Å) 主引用文献 Crystal Structure Analysis of BCL11A in complex with DNA To Be Published
8THO	Solution structure of the zinc finger repeat domain of BCL11A (ZnF456) 分子名称: B-cell lymphoma/leukemia 11A, ZINC ION 著者 Viennet, T, Yin, M, Orkin, S.H, Arthanari, H. 登録日 2023-07-17 公開日 2024-07-24 実験手法 SOLUTION NMR 主引用文献 Structural and dynamic investigation of DNA-binding by BCL11A reveals a specific role for ZnF6 To Be Published
9CJA	Formerly degenerate seventh zinc finger domain from transcription factor ZNF711 rehabilitated by experimental NMR structure 分子名称: ZINC ION, Zinc finger protein 711 著者 Rua, A.J, Alexandrescu, A.T. 登録日 2024-07-05 公開日 2024-07-17 最終更新日 2024-10-09 実験手法 SOLUTION NMR 主引用文献 Formerly degenerate seventh zinc finger domain from transcription factor ZNF711 rehabilitated by experimental NMR structure. Protein Sci., 33, 2024
8JPY	Solution NMR Structure of Zinc-fingers 1 and 2 (fragment 257-320) from human Insulinoma-associated protein 1(INSM1) 分子名称: Insulinoma-associated protein 1, ZINC ION 著者 He, X.L, Yang, Y.H. 登録日 2023-06-13 公開日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 Solution NMR Structure of Zinc-fingers 1 and 2 (fragment 257-320) from human Insulinoma-associated protein 1(INSM1) To Be Published
8JQ1	Solution NMR Structure of zinc fingers 1-2 (fragment 257-320) from human insulinoma-associated protein 1(INSM1) 分子名称: Insulinoma-associated protein 1, ZINC ION 著者 He, X.L, Yang, Y.H. 登録日 2023-06-13 公開日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 Solution NMR Structure of zinc fingers 1-2 (fragment 257-320) from human insulinoma-associated protein 1(INSM1) To Be Published
9AZI	NMR solution structure of cell-permeant miniature protein ZF5.3 分子名称: Designed Zinc finger protein 5.3, ZINC ION 著者 Giudice, J.A, Kelly, M, Schepartz, A. 登録日 2024-03-11 公開日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Structural and mechanistic basis for efficient endosomal escape by designed mini-proteins To be published
8TNR	Cryo-EM structure of DDB1dB:CRBN:PT-179:SD40, conformation 2 分子名称: 2-[(3S)-2,6-dioxopiperidin-3-yl]-5-(morpholin-4-yl)-1H-isoindole-1,3(2H)-dione, DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, ... 著者 Roy Burman, S.S, Hunkeler, M, Fischer, E.S. 登録日 2023-08-02 公開日 2024-03-13 最終更新日 2024-04-03 実験手法 ELECTRON MICROSCOPY (2.5 Å) 主引用文献 Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science, 383, 2024
8TNP	Cryo-EM structure of DDB1dB:CRBN:Pomalidomide:SD40 分子名称: DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, Protein cereblon, ... 著者 Roy Burman, S.S, Hunkeler, M, Fischer, E.S. 登録日 2023-08-02 公開日 2024-03-13 最終更新日 2024-04-03 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science, 383, 2024
8TNQ	Cryo-EM structure of DDB1dB:CRBN:PT-179:SD40, conformation 1 分子名称: 2-[(3S)-2,6-dioxopiperidin-3-yl]-5-(morpholin-4-yl)-1H-isoindole-1,3(2H)-dione, DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, ... 著者 Roy Burman, S.S, Hunkeler, M, Fischer, E.S. 登録日 2023-08-02 公開日 2024-03-13 最終更新日 2024-04-03 実験手法 ELECTRON MICROSCOPY (2.41 Å) 主引用文献 Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science, 383, 2024
8U16	The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-short bound to Pomalidomide 分子名称: 1,2-ETHANEDIOL, DNA damage-binding protein 1, Protein cereblon, ... 著者 Clifton, M.C, Ma, X, Ornelas, E. 登録日 2023-08-30 公開日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon. Sci Rep, 13, 2023
8U17	The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-long bound to Pomalidomide 分子名称: DNA damage-binding protein 1, Protein cereblon, S-Pomalidomide, ... 著者 Clifton, M.C, Ma, X, Ornelas, E. 登録日 2023-08-30 公開日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon. Sci Rep, 13, 2023
8U15	The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-short bound to CC-220 分子名称: (3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, DDB1, Protein cereblon, ... 著者 Clifton, M.C, Ma, X, Ornelas, E. 登録日 2023-08-30 公開日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon. Sci Rep, 13, 2023
7YSF	Crystal structure of ZNF524 ZF1-4 in complex with telomeric DNA 分子名称: D-MALATE, DNA (5'-D(*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*TP*AP*AP*CP*CP*CP*TP*AP*AP*CP*CP*C)-3'), ... 著者 Li, F.D, Xu, Z.Y. 登録日 2022-08-12 公開日 2023-08-16 最終更新日 2024-04-24 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 ZNF524 directly interacts with telomeric DNA and supports telomere integrity. Nat Commun, 14, 2023
8SSU	ZnFs 3-11 of CCCTC-binding factor (CTCF) Complexed with 19mer DNA 分子名称: 1,2-ETHANEDIOL, DNA (19-MER) Strand I, DNA (19-MER) Strand II, ... 著者 Horton, J.R, Yang, J, Cheng, X. 登録日 2023-05-08 公開日 2023-08-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 Structures of CTCF-DNA complexes including all 11 zinc fingers. Nucleic Acids Res., 51, 2023
8SST	ZnFs 1-7 of CCCTC-binding factor (CTCF) K365T Mutant Complexed with 23mer 分子名称: 1,2-ETHANEDIOL, DNA Strand (23mer) I, DNA Strand (23mer) II, ... 著者 Horton, J.R, Yang, J, Cheng, X. 登録日 2023-05-08 公開日 2023-08-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 Structures of CTCF-DNA complexes including all 11 zinc fingers. Nucleic Acids Res., 51, 2023
8SSS	ZnFs 1-7 of CCCTC-binding factor (CTCF) Complexed with 23mer 分子名称: 1,2-ETHANEDIOL, DNA Strand (23mer) I, DNA Strand (23mer) II, ... 著者 Horton, J.R, Yang, J, Cheng, X. 登録日 2023-05-08 公開日 2023-08-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structures of CTCF-DNA complexes including all 11 zinc fingers. Nucleic Acids Res., 51, 2023
8SSQ	ZnFs 3-11 of CCCTC-binding factor (CTCF) Complexed with 35mer DNA 35-4 分子名称: DNA (35-MER) Strand 2, DNA (35-MER) Strand I, SODIUM ION, ... 著者 Horton, J.R, Yang, J, Cheng, X. 登録日 2023-05-08 公開日 2023-08-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.12 Å) 主引用文献 Structures of CTCF-DNA complexes including all 11 zinc fingers. Nucleic Acids Res., 51, 2023
8SSR	ZnFs 3-11 of CCCTC-binding factor (CTCF) Complexed with 35mer DNA 35-20 分子名称: DNA (35-MER) Strand I, DNA (35-MER) Strand II, SODIUM ION, ... 著者 Horton, J.R, Yang, J, Cheng, X. 登録日 2023-05-08 公開日 2023-08-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.14 Å) 主引用文献 Structures of CTCF-DNA complexes including all 11 zinc fingers. Nucleic Acids Res., 51, 2023
8FFZ	TFIIIA-TFIIIC-Brf1-TBP complex bound to 5S rRNA gene 分子名称: DNA (151-MER), Transcription factor IIIA, Transcription factor IIIB 70 kDa subunit,TATA-box-binding protein, ... 著者 Talyzina, A, He, Y. 登録日 2022-12-11 公開日 2023-06-21 最終更新日 2023-08-16 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structural basis of TFIIIC-dependent RNA polymerase III transcription initiation. Mol.Cell, 83, 2023
7W1M	Cryo-EM structure of human cohesin-CTCF-DNA complex 分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cohesin subunit SA-1, ... 著者 Shi, Z.B, Bai, X.C, Yu, H. 登録日 2021-11-19 公開日 2023-05-31 最終更新日 2023-12-13 実験手法 ELECTRON MICROSCOPY (6.5 Å) 主引用文献 CTCF and R-loops are boundaries of cohesin-mediated DNA looping. Mol.Cell, 83, 2023
8CUC	Crystal structure analysis of SALL4 zinc finger domain in complex with DNA 分子名称: DNA (5'-D(P*CP*GP*AP*AP*AP*TP*AP*TP*TP*AP*GP*C)-3'), DNA (5'-D(P*GP*CP*TP*AP*AP*TP*AP*TP*TP*TP*CP*G)-3'), Sal-like protein 4, ... 著者 Seo, H.S, Dhe-Paganon, S. 登録日 2022-05-17 公開日 2023-05-24 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Crystal Structure Analysis of SALL4 Zinc Finger domain in complex with DNA To Be Published
8H9H	Crystal structure of ZBTB7A in complex with GACCC-containing sequence 分子名称: DNA (5'-D(*TP*AP*AP*GP*GP*AP*CP*CP*CP*AP*GP*AP*T)-3'), DNA (5'-D(P*AP*AP*TP*CP*TP*GP*GP*GP*TP*CP*CP*TP*T)-3'), ZINC ION, ... 著者 Yang, Y. 登録日 2022-10-25 公開日 2023-04-26 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 ZBTB7A regulates primed-to-naive transition of pluripotent stem cells via recognition of the PNT-associated sequence by zinc fingers 1-2 and recognition of gamma-globin -200 gene element by zinc fingers 1-4. Febs J., 290, 2023
8DEY	Ternary complex structure of Cereblon-DDB1 bound to IKZF2(ZF2,3) and the molecular glue DKY709 分子名称: (3S)-3-[5-(1-benzylpiperidin-4-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, DNA damage-binding protein 1, Protein cereblon, ... 著者 Ma, X, Ornelas, E, Clifton, M.C. 登録日 2022-06-21 公開日 2023-03-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy. Cell Chem Biol, 30, 2023
7U8F	Ternary complex structure of Cereblon-DDB1 bound to IKZF2(ZF2) and the molecular glue DKY709 分子名称: (3S)-3-[5-(1-benzylpiperidin-4-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DNA damage-binding protein 1, ... 著者 Ma, X, Ornelas, E, Clifton, M.C. 登録日 2022-03-08 公開日 2023-03-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy. Cell Chem Biol, 30, 2023

 

12345678910111213>