7YSF

Crystal structure of ZNF524 ZF1-4 in complex with telomeric DNA

Summary for 7YSF

• Entry DOI: 10.2210/pdb7ysf/pdb
• Descriptor: Zinc finger protein 524, DNA (5'-D(*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*TP*AP*AP*CP*CP*CP*TP*AP*AP*CP*CP*C)-3'), ... (6 entities in total)
• Functional Keywords: c2h2 zinc finger, dna binding protein, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 25163.91

Authors

Li, F.D.,Xu, Z.Y. (deposition date: 2022-08-12, release date: 2023-08-16, Last modification date: 2024-04-24)

• Primary citation: Braun, H.,Xu, Z.,Chang, F.,Viceconte, N.,Rane, G.,Levin, M.,Lototska, L.,Roth, F.,Hillairet, A.,Fradera-Sola, A.,Khanchandani, V.,Sin, Z.W.,Yong, W.K.,Dreesen, O.,Yang, Y.,Shi, Y.,Li, F.,Butter, F.,Kappei, D.; ZNF524 directly interacts with telomeric DNA and supports telomere integrity.; Nat Commun, 14:8252-8252, 2023; PubMed: 38086788; DOI: 10.1038/s41467-023-43397-7

Experimental method

X-RAY DIFFRACTION (2.4 Å)