8DEY
Ternary complex structure of Cereblon-DDB1 bound to IKZF2(ZF2,3) and the molecular glue DKY709
Summary for 8DEY
Entry DOI | 10.2210/pdb8dey/pdb |
Descriptor | Protein cereblon, DNA damage-binding protein 1, Zinc finger protein Helios, ... (5 entities in total) |
Functional Keywords | e3 ligase, molecular glue, complex, ligase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 286534.37 |
Authors | Ma, X.,Ornelas, E.,Clifton, M.C. (deposition date: 2022-06-21, release date: 2023-03-08, Last modification date: 2023-10-25) |
Primary citation | Bonazzi, S.,d'Hennezel, E.,Beckwith, R.E.J.,Xu, L.,Fazal, A.,Magracheva, A.,Ramesh, R.,Cernijenko, A.,Antonakos, B.,Bhang, H.C.,Caro, R.G.,Cobb, J.S.,Ornelas, E.,Ma, X.,Wartchow, C.A.,Clifton, M.C.,Forseth, R.R.,Fortnam, B.H.,Lu, H.,Csibi, A.,Tullai, J.,Carbonneau, S.,Thomsen, N.M.,Larrow, J.,Chie-Leon, B.,Hainzl, D.,Gu, Y.,Lu, D.,Meyer, M.J.,Alexander, D.,Kinyamu-Akunda, J.,Sabatos-Peyton, C.A.,Dales, N.A.,Zecri, F.J.,Jain, R.K.,Shulok, J.,Wang, Y.K.,Briner, K.,Porter, J.A.,Tallarico, J.A.,Engelman, J.A.,Dranoff, G.,Bradner, J.E.,Visser, M.,Solomon, J.M. Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy. Cell Chem Biol, 30:235-247.e12, 2023 Cited by PubMed: 36863346DOI: 10.1016/j.chembiol.2023.02.005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.7 Å) |
Structure validation
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