8DEY

Ternary complex structure of Cereblon-DDB1 bound to IKZF2(ZF2,3) and the molecular glue DKY709

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0003676	molecular_function	nucleic acid binding
B	0005634	cellular_component	nucleus
E	0003676	molecular_function	nucleic acid binding
E	0005634	cellular_component	nucleus

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	21
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cnq..CgasFtqkgnllrHikl..H

Chain	Residue	Details
C	CYS142-HIS162
C	CYS170-HIS190

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	44
Details	ZN_FING: C2H2-type 2 => ECO:0000255|PROSITE-ProRule:PRU00042

Chain	Residue	Details
C	PHE140-HIS162
D	HIS378
D	TRP380
D	TRP386
D	CYS391
D	CYS394
F	PHE140-HIS162
A	HIS378
A	TRP380
A	TRP386
A	CYS391
A	CYS394
D	CYS323
D	CYS326

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site_id	SWS_FT_FI2
Number of Residues	44
Details	ZN_FING: C2H2-type 3 => ECO:0000255|PROSITE-ProRule:PRU00042

Chain	Residue	Details
C	PHE168-HIS190
F	PHE168-HIS190

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q9ESW0

Chain	Residue	Details
B	THR1125
E	THR1125

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site_id	SWS_FT_FI4
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
B	LYS1121
E	LYS1121

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