8DEY

Ternary complex structure of Cereblon-DDB1 bound to IKZF2(ZF2,3) and the molecular glue DKY709

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, D)	Protein cereblon	polymer	373	42971.6	2	UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226)	Homo sapiens (human)
2	B, E (B, E)	DNA damage-binding protein 1	polymer	836	93347.1	2	UniProt (Q16531) Pfam (PF10433) Pfam (PF03178)	Homo sapiens (human)	DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe
3	C, F (C, F)	Zinc finger protein Helios	polymer	57	6543.6	2	UniProt (Q9UKS7) Pfam (PF00096)	Homo sapiens (human)	Ikaros family zinc finger protein 2
4	G, I, J, K, L... (A, C, D, F)	ZINC ION	non-polymer		65.4	6	Chemie (ZN)
5	H (A)	(3S)-3-[5-(1-benzylpiperidin-4-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione	non-polymer		417.5	1	Chemie (LWK)

Sequence modifications

B, E: 1 - 699 (UniProt: Q16531)
B, E: 706 - 1140 (UniProt: Q16531)

PDB	External Database	Details
Gly 700	-	linker
Asn 701	-	linker
Gly 702	-	linker
Asn 703	-	linker
Ser 704	-	linker
Gly 705	-	linker

C, F: 137 - 192 (UniProt: Q9UKS7)

PDB	External Database	Details
Ser 136	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	285724.4
Non-Polymers*	Number of molecules	7
	Total formula weight	810.0
All*	Total formula weight	286534.4

*Water molecules are not included.