8RQC

Crystal structure of CRBN-midi in complex with mezigdomide and IKZF1 ZF2

Summary for 8RQC

• Entry DOI: 10.2210/pdb8rqc/pdb
• Descriptor: Protein cereblon, DNA-binding protein Ikaros, ZINC ION, ... (5 entities in total)
• Functional Keywords: e3 ligase, protac, tpd, molecular glue, targeted protein degradation, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 84393.69

Authors

Furihata, H.,Kroupova, A.,Zollman, D.,Ciulli, A. (deposition date: 2024-01-17, release date: 2024-09-25)

• Primary citation: Kroupova, A.,Spiteri, V.,Furihata, H.,Darren, D.,Ramachandran, S.,Rutter, Z.,Chakraborti, S.,Haubrich, K.,Pethe, J.,Gonzales, D.,Wijaya, A.,Rodriguez-Rios, M.,Lynch, D.,Farnaby, W.,Nakasone, M.,Zollman, D.,Ciulli, A.; Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.15 Å)