8RQC
Crystal structure of CRBN-midi in complex with mezigdomide and IKZF1 ZF2
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, D | Protein cereblon | polymer | 329 | 37478.8 | 2 | UniProt (Q96SW2) In PDB | Homo sapiens (human) | |
2 | B, E | DNA-binding protein Ikaros | polymer | 36 | 4019.6 | 2 | UniProt (Q13422) In PDB | Homo sapiens (human) | Ikaros family zinc finger protein 1,Lymphoid transcription factor LyF-1 |
3 | A, B, D, E | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
4 | A, D | Mezigdomide | non-polymer | 567.6 | 2 | Chemie (QFC) | |||
5 | water | water | 18.0 | 179 | Chemie (HOH) |
Sequence modifications
A, D: 41 - 187 (UniProt: Q96SW2)
A, D: 249 - 426 (UniProt: Q96SW2)
B, E: 141 - 174 (UniProt: Q13422)
PDB | External Database | Details |
---|---|---|
Ser 40 | - | expression tag |
Ile 78 | Cys 78 | engineered mutation |
Val 92 | Ile 92 | engineered mutation |
Asn 116 | Lys 116 | engineered mutation |
Glu 134 | Gln 134 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 188 | - | linker |
Ser 189 | - | linker |
Gly 190 | - | linker |
Trp 283 | Arg 283 | engineered mutation |
Asn 287 | Cys 287 | engineered mutation |
Ser 293 | Val 293 | engineered mutation |
Asp 302 | Gly 302 | engineered mutation |
Arg 342 | Leu 342 | engineered mutation |
Glu 343 | Cys 343 | engineered mutation |
Ile 359 | Thr 359 | engineered mutation |
Ile 423 | Leu 423 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 139 | - | expression tag |
Pro 140 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 82996.8 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1396.9 | |
All* | Total formula weight | 84393.7 |