8RQC
Crystal structure of CRBN-midi in complex with mezigdomide and IKZF1 ZF2
Functional Information from PROSITE/UniProt
| site_id | PS00028 |
| Number of Residues | 21 |
| Details | ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cnq..CgasFtqkgnllrHikl..H |
| Chain | Residue | Details |
| B | CYS147-HIS167 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 44 |
| Details | ZN_FING: C2H2-type 2 => ECO:0000255|PROSITE-ProRule:PRU00042 |
| Chain | Residue | Details |
| B | PHE145-HIS167 | |
| D | HIS378 | |
| D | TRP380 | |
| D | TRP386 | |
| D | CYS391 | |
| D | CYS394 | |
| E | PHE145-HIS167 | |
| A | HIS378 | |
| A | TRP380 | |
| A | TRP386 | |
| A | CYS391 | |
| A | CYS394 | |
| D | CYS323 | |
| D | CYS326 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | SITE: Required for both pericentromeric heterochromatin localization and complete DNA binding => ECO:0000250 |
| Chain | Residue | Details |
| B | ASN159 | |
| B | ARG162 | |
| E | ASN159 | |
| E | ARG162 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q03267 |
| Chain | Residue | Details |
| B | SER168 | |
| E | SER168 |
