6L8S
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![BU of 6l8s by Molmil](/molmil-images/mine/6l8s) | High resolution crystal structure of crustacean hemocyanin. | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Masuda, T, Mikami, B, Baba, S. | 登録日 | 2019-11-07 | 公開日 | 2020-05-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | The high-resolution crystal structure of lobster hemocyanin shows its enzymatic capability as a phenoloxidase. Arch.Biochem.Biophys., 688, 2020
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3H9Y
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![BU of 3h9y by Molmil](/molmil-images/mine/3h9y) | Crystal structure of the IgE-Fc3-4 domains | 分子名称: | AMMONIUM ION, Ig epsilon chain C region, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Wurzburg, B.A. | 登録日 | 2009-04-30 | 公開日 | 2009-09-08 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | Conformational flexibility in immunoglobulin E-Fc 3-4 revealed in multiple crystal forms. J.Mol.Biol., 393, 2009
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8SDB
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![BU of 8sdb by Molmil](/molmil-images/mine/8sdb) | Crystal Structure of E.Coli Branching Enzyme in complex with malto-octose | 分子名称: | 1,4-alpha-glucan branching enzyme GlgB, alpha-D-glucopyranose, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ... | 著者 | Bingham, C.R, Nayebi, H, Fawaz, R, Geiger, J.H. | 登録日 | 2023-04-06 | 公開日 | 2023-07-12 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The Structure of Maltooctaose-Bound Escherichia coli Branching Enzyme Suggests a Mechanism for Donor Chain Specificity. Molecules, 28, 2023
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6LGE
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![BU of 6lge by Molmil](/molmil-images/mine/6lge) | Bombyx mori GH13 sucrose hydrolase complexed with acarbose | 分子名称: | 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose, CALCIUM ION, MAGNESIUM ION, ... | 著者 | Miyazaki, T. | 登録日 | 2019-12-05 | 公開日 | 2020-05-20 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structure-function analysis of silkworm sucrose hydrolase uncovers the mechanism of substrate specificity in GH13 subfamily 17exo-alpha-glucosidases. J.Biol.Chem., 295, 2020
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5K8D
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![BU of 5k8d by Molmil](/molmil-images/mine/5k8d) | Crystal structure of rFVIIIFc | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, COPPER (II) ION, ... | 著者 | Leksa, N, Quan, C. | 登録日 | 2016-05-29 | 公開日 | 2017-06-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (4.19 Å) | 主引用文献 | The structural basis for the functional comparability of factor VIII and the long-acting variant recombinant factor VIII Fc fusion protein. J. Thromb. Haemost., 15, 2017
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6UAW
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![BU of 6uaw by Molmil](/molmil-images/mine/6uaw) | Crystal structure of a GH128 (subgroup II) endo-beta-1,3-glucanase from Pseudomonas viridiflava (PvGH128_II) in complex with laminaritriose | 分子名称: | Glyco_hydro_cc domain-containing protein, SULFATE ION, beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose | 著者 | Santos, C.R, Costa, P.A.C.R, Lima, E.A, Mandelli, F, Murakami, M.T. | 登録日 | 2019-09-11 | 公開日 | 2020-05-20 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural insights into beta-1,3-glucan cleavage by a glycoside hydrolase family. Nat.Chem.Biol., 16, 2020
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6LJR
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![BU of 6ljr by Molmil](/molmil-images/mine/6ljr) | human galectin-16 R55N/H57R | 分子名称: | Galectin-16, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | 著者 | Su, J. | 登録日 | 2019-12-17 | 公開日 | 2020-10-14 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Human galectin-16 has a pseudo ligand binding site and plays a role in regulating c-Rel-mediated lymphocyte activity. Biochim Biophys Acta Gen Subj, 1865, 2020
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6XL4
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![BU of 6xl4 by Molmil](/molmil-images/mine/6xl4) | EGFR(T790M/V948R) in complex with AZD9291 and DDC4002 | 分子名称: | 10-benzyl-8-fluoro-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one, Epidermal growth factor receptor, MAGNESIUM ION, ... | 著者 | Heppner, D.E, Beyett, T.S, Eck, M.J. | 登録日 | 2020-06-28 | 公開日 | 2021-06-30 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors. Nat Commun, 13, 2022
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6RWF
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1A7C
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![BU of 1a7c by Molmil](/molmil-images/mine/1a7c) | HUMAN PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 IN COMPLEX WITH A PENTAPEPTIDE | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-D-ribopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, PENTAPEPTIDE, ... | 著者 | Xue, Y, Inghardt, T, Sjolin, L, Deinum, J. | 登録日 | 1998-03-12 | 公開日 | 1999-03-23 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide Structure, 6, 1998
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3VGF
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![BU of 3vgf by Molmil](/molmil-images/mine/3vgf) | Crystal structure of glycosyltrehalose trehalohydrolase (D252S) complexed with maltotriosyltrehalose | 分子名称: | CITRATE ANION, GLYCEROL, Malto-oligosyltrehalose trehalohydrolase, ... | 著者 | Okazaki, N, Tamada, T, Feese, M.D, Kato, M, Miura, Y, Komeda, T, Kobayashi, K, Kondo, K, Kuroki, R. | 登録日 | 2011-08-09 | 公開日 | 2012-06-20 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Substrate recognition mechanism of a glycosyltrehalose trehalohydrolase from Sulfolobus solfataricus KM1. Protein Sci., 21, 2012
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4ZG7
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![BU of 4zg7 by Molmil](/molmil-images/mine/4zg7) | Structural basis for inhibition of human autotaxin by four novel compounds | 分子名称: | (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-({6-chloro-7-fluoro-2-methyl-1-[2-oxo-2-(spiro[cyclopropane-1,3'-indol]-1'(2'H)-yl)ethyl]-1H-indol-3-yl}sulfanyl)-2-fluorobenzoic acid, ... | 著者 | Stein, A.J, Bain, G, Hutchinson, J.H, Evans, J.F. | 登録日 | 2015-04-22 | 公開日 | 2015-10-14 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding. Mol.Pharmacol., 88, 2015
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6LJL
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![BU of 6ljl by Molmil](/molmil-images/mine/6ljl) | Crystal Structure of exoHep-Y390A/H555A complexed with a tetrasaccharide substrate | 分子名称: | 4-deoxy-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, CALCIUM ION, Heparinase II/III-like protein | 著者 | Zhang, Q.D, Cao, H.Y, Wei, L, Li, F.C, Zhang, Y.Z. | 登録日 | 2019-12-17 | 公開日 | 2020-12-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Discovery of exolytic heparinases and their catalytic mechanism and potential application. Nat Commun, 12, 2021
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3H3G
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6UAT
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![BU of 6uat by Molmil](/molmil-images/mine/6uat) | Crystal structure of a GH128 (subgroup I) endo-beta-1,3-glucanase (E102A mutant) from Amycolatopsis mediterranei (AmGH128_I) in complex with laminaripentaose | 分子名称: | Glyco_hydro_cc domain-containing protein, ZINC ION, beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose | 著者 | Vieira, P.S, Cabral, L, Costa, P.A.C.R, Santos, C.R, Murakami, M.T. | 登録日 | 2019-09-11 | 公開日 | 2020-05-20 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural insights into beta-1,3-glucan cleavage by a glycoside hydrolase family. Nat.Chem.Biol., 16, 2020
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7NHG
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7NIA
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7NI9
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7NHV
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![BU of 7nhv by Molmil](/molmil-images/mine/7nhv) | Crystal structure of the human METTL3-METTL14 complex with compound UOZ016 | 分子名称: | (R)-N-((1-(6-(benzylamino)pyrimidin-4-yl)-3-hydroxypiperidin-3-yl)methyl)-4-((4,4-dimethylpiperidin-1-yl)methyl)benzamide, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... | 著者 | Bedi, R.K, Huang, D, Caflisch, A. | 登録日 | 2021-02-11 | 公開日 | 2021-10-20 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3 Acs Bio Med Chem Au, 2023
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7NHH
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7NI7
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![BU of 7ni7 by Molmil](/molmil-images/mine/7ni7) | Crystal structure of the human METTL3-METTL14 complex with compound UOZ031 | 分子名称: | (R)-4-((4,4-dimethylpiperidin-1-yl)methyl)-2-hydroxy-N-((3-hydroxy-1-(6-((3-(methylcarbamoyl)benzyl)amino)pyrimidin-4-yl)piperidin-3-yl)methyl)benzamide, ACETATE ION, MAGNESIUM ION, ... | 著者 | Bedi, R.K, Huang, D, Caflisch, A. | 登録日 | 2021-02-11 | 公開日 | 2021-10-20 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3 Acs Bio Med Chem Au, 2023
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6S1X
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7NID
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![BU of 7nid by Molmil](/molmil-images/mine/7nid) | Crystal structure of the human METTL3-METTL14 complex with compound UOZ078 | 分子名称: | (R)-1-(6-(benzylamino)pyrimidin-4-yl)-3-(((6-((4,4-dimethylpiperidin-1-yl)methyl)naphthalen-1-yl)amino)methyl)piperidin-3-ol, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... | 著者 | Bedi, R.K, Huang, D, Caflisch, A. | 登録日 | 2021-02-11 | 公開日 | 2021-10-20 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3 Acs Bio Med Chem Au, 2023
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8SVY
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![BU of 8svy by Molmil](/molmil-images/mine/8svy) | MBP-Mcl1 in complex with ligand 10 | 分子名称: | (15P)-17-chloro-33-fluoro-12-[(2-methoxyethoxy)methyl]-5,14,22-trimethyl-28-oxa-9-thia-5,6,13,14,22-pentaazaheptacyclo[27.7.1.1~4,7~.0~11,15~.0~16,21~.0~20,24~.0~30,35~]octatriaconta-1(36),4(38),6,11(15),12,16,18,20,23,29(37),30,32,34-tridecaene-23-carboxylic acid, 1,2-ETHANEDIOL, GLYCEROL, ... | 著者 | Miller, B.R, Shaffer, P. | 登録日 | 2023-05-17 | 公開日 | 2023-08-09 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Macrocyclic Carbon-Linked Pyrazoles As Novel Inhibitors of MCL-1. Acs Med.Chem.Lett., 14, 2023
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7NHJ
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