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6XL4

EGFR(T790M/V948R) in complex with AZD9291 and DDC4002

Summary for 6XL4
Entry DOI10.2210/pdb6xl4/pdb
DescriptorEpidermal growth factor receptor, ~{N}-[2-[2-(dimethylamino)ethyl-methyl-amino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]propanamide, 10-benzyl-8-fluoro-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one, ... (6 entities in total)
Functional Keywordscancer, chemotherapy, kinase inhibitors, allosteric, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total formula weight152406.25
Authors
Heppner, D.E.,Beyett, T.S.,Eck, M.J. (deposition date: 2020-06-28, release date: 2021-06-30, Last modification date: 2023-10-18)
Primary citationBeyett, T.S.,To, C.,Heppner, D.E.,Rana, J.K.,Schmoker, A.M.,Jang, J.,De Clercq, D.J.H.,Gomez, G.,Scott, D.A.,Gray, N.S.,Janne, P.A.,Eck, M.J.
Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors.
Nat Commun, 13:2530-2530, 2022
Cited by
PubMed: 35534503
DOI: 10.1038/s41467-022-30258-y
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.06 Å)
Structure validation

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