6XL4
EGFR(T790M/V948R) in complex with AZD9291 and DDC4002
Summary for 6XL4
Entry DOI | 10.2210/pdb6xl4/pdb |
Descriptor | Epidermal growth factor receptor, ~{N}-[2-[2-(dimethylamino)ethyl-methyl-amino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]propanamide, 10-benzyl-8-fluoro-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one, ... (6 entities in total) |
Functional Keywords | cancer, chemotherapy, kinase inhibitors, allosteric, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 152406.25 |
Authors | Heppner, D.E.,Beyett, T.S.,Eck, M.J. (deposition date: 2020-06-28, release date: 2021-06-30, Last modification date: 2023-10-18) |
Primary citation | Beyett, T.S.,To, C.,Heppner, D.E.,Rana, J.K.,Schmoker, A.M.,Jang, J.,De Clercq, D.J.H.,Gomez, G.,Scott, D.A.,Gray, N.S.,Janne, P.A.,Eck, M.J. Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors. Nat Commun, 13:2530-2530, 2022 Cited by PubMed: 35534503DOI: 10.1038/s41467-022-30258-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.06 Å) |
Structure validation
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