7NHG
Crystal structure of the human METTL3-METTL14 complex with compound ASI_M3M_041
Summary for 7NHG
| Entry DOI | 10.2210/pdb7nhg/pdb |
| Descriptor | N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, N-[[(3R)-3-Hydroxy-1-[6-(methylamino)pyrimidin-4-yl]piperidin-3-yl]methyl]-4-(piperidin-1-ylmethyl)benzamide, ... (5 entities in total) |
| Functional Keywords | mettl3, mettl14, m6a, inhibitor, complex, transferase |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 62262.94 |
| Authors | Bedi, R.K.,Huang, D.,Caflisch, A. (deposition date: 2021-02-10, release date: 2021-10-20, Last modification date: 2024-02-07) |
| Primary citation | Bedi, R.K.,Huang, D.,Li, Y.,Caflisch, A. Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3 Acs Bio Med Chem Au, 2023 Cited by DOI: 10.1021/acsbiomedchemau.3c00023PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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