PDB: 42250 件ウェブページステータス検索Chemie searchBIRD

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5A4B	Mutations in the Calponin homology domain of Alpha-Actinin-2 affect Actin binding and incorporation in muscle. 分子名称: HUMAN ALPHA-ACTININ-2 著者 Haywood, N.J, Wolny, M, Trinh, C.H, Shuping, Y, Edwards, T.A, Peckham, M. 登録日 2015-06-05 公開日 2016-06-22 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Hypertrophic Cardiomyopathy Mutations in the Calponin-Homology Domain of Actn2 Affect Actin Binding and Cardiomyocyte Z-Disc Incorporation. Biochem.J., 473, 2016
3LD5	Human aldose reductase mutant T113S complexed with IDD594 分子名称: Aldose reductase, BROMIDE ION, CITRIC ACID, ... 著者 Koch, C, Heine, A, Klebe, G. 登録日 2010-01-12 公開日 2010-12-15 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.27 Å) 主引用文献 Tracing the detail: how mutations affect binding modes and thermodynamic signatures of closely related aldose reductase inhibitors J.Mol.Biol., 406, 2011
4AHM	V113I - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis 分子名称: ANGIOGENIN, L(+)-TARTARIC ACID 著者 Thiyagarajan, N, Ferguson, R, Saha, S, Pham, T, Subramanian, V, Acharya, K.R. 登録日 2012-02-06 公開日 2012-10-10 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Structural and Molecular Insights Into the Mechanism of Action of Human Angiogenin-Als Variants in Neurons. Nat.Commun., 3, 2012
4AHI	K40I - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis 分子名称: ANGIOGENIN 著者 Thiyagarajan, N, Ferguson, R, Saha, S, Pham, T, Subramanian, V, Acharya, K.R. 登録日 2012-02-06 公開日 2012-10-10 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.798 Å) 主引用文献 Structural and Molecular Insights Into the Mechanism of Action of Human Angiogenin-Als Variants in Neurons. Nat.Commun., 3, 2012
8ET8	Cryo-EM structure of the organic cation transporter 1 in complex with verapamil 分子名称: (2S)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, OCT1 著者 Suo, Y, Wright, N.J, Lee, S.-Y. 登録日 2022-10-16 公開日 2023-05-31 最終更新日 2024-11-13 実験手法 ELECTRON MICROSCOPY (3.45 Å) 主引用文献 Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2. Nat.Struct.Mol.Biol., 30, 2023
8ET9	Cryo-EM structure of the organic cation transporter 2 in complex with 1-methyl-4-phenylpyridinium 分子名称: 1-methyl-4-phenylpyridin-1-ium, OCT2 著者 Suo, Y, Wright, N.J, Lee, S.-Y. 登録日 2022-10-16 公開日 2023-05-31 最終更新日 2024-10-23 実験手法 ELECTRON MICROSCOPY (3.61 Å) 主引用文献 Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2. Nat.Struct.Mol.Biol., 30, 2023
1GP5	Anthocyanidin synthase from Arabidopsis thaliana complexed with trans-dihydroquercetin 分子名称: (2R,3R)-2-(3,4-DIHYDROXYPHENYL)-3,5,7-TRIHYDROXY-2,3-DIHYDRO-4H-CHROMEN-4-ONE, (2S,3S)-2-(3,4-DIHYDROXYPHENYL)-3,5,7-TRIHYDROXY-2,3-DIHYDRO-4H-CHROMEN-4-ONE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... 著者 Wilmouth, R.C, Turnbull, J.J, Welford, R.W.D, Clifton, I.J, Prescott, A.G, Schofield, C.J. 登録日 2001-10-30 公開日 2002-02-21 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure and Mechanism of Anthocyanidin Synthase from Arabidopsis Thaliana. Structure, 10, 2002
1Q8U	The Catalytic Subunit of cAMP-dependent Protein Kinase in Complex with Rho-kinase Inhibitor H-1152P 分子名称: (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE, N-OCTANOYL-N-METHYLGLUCAMINE, cAMP-dependent protein kinase inhibitor, ... 著者 Breitenlechner, C, Gassel, M, Hidaka, H, Kinzel, V, Huber, R, Engh, R.A, Bossemeyer, D. 登録日 2003-08-22 公開日 2003-12-16 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity. Structure, 11, 2003
3PJJ	Synthetic Dimer of Human Carbonic Anhydrase II 分子名称: 1,1'-(oxydimethanediyl)dipyrrolidine-2,5-dione, Carbonic anhydrase 2, ZINC ION 著者 Snyder, P.W, Kwant, R.L, Moustakas, D.T, Mack, E.T, Butte, M.J, Whitesides, G.W. 登録日 2010-11-10 公開日 2012-01-18 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 One Interface Stabilizes Linear Chains in All Polymorphs of Crystals of Human Carbonic Anhydrase II To be Published
8EMS	Cryo-EM structure of human liver glycogen phosphorylase 分子名称: Glycogen phosphorylase, liver form, PYRIDOXAL-5'-PHOSPHATE 著者 Su, C, Lyu, M, Zhang, Z, Yu, E.W. 登録日 2022-09-28 公開日 2023-05-10 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (2.65 Å) 主引用文献 High-resolution structural-omics of human liver enzymes. Cell Rep, 42, 2023
1YDR	STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH H7 PROTEIN KINASE INHIBITOR 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE 分子名称: 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE, C-AMP-DEPENDENT PROTEIN KINASE, PROTEIN KINASE INHIBITOR PEPTIDE 著者 Engh, R.A, Girod, A, Kinzel, V, Huber, R, Bossemeyer, D. 登録日 1996-07-24 公開日 1997-04-01 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity. J.Biol.Chem., 271, 1996
8ET6	Cryo-EM structure of the organic cation transporter 1 in the apo state 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, OCT1 著者 Suo, Y, Wright, N.J, Lee, S.-Y. 登録日 2022-10-16 公開日 2023-05-31 最終更新日 2024-10-23 実験手法 ELECTRON MICROSCOPY (3.57 Å) 主引用文献 Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2. Nat.Struct.Mol.Biol., 30, 2023
1ALD	ACTIVITY AND SPECIFICITY OF HUMAN ALDOLASES 分子名称: ALDOLASE A 著者 Watson, H.C. 登録日 1991-05-05 公開日 1992-01-15 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Activity and specificity of human aldolases. J.Mol.Biol., 219, 1991
6SEV	Structure of Dps from Listeria innocua soaked with 10 mM zinc for 120 minutes 分子名称: DNA starvation/stationary phase protection protein, ZINC ION 著者 Zeth, K, Okuda, M. 登録日 2019-07-30 公開日 2019-09-25 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Metal Positions and Translocation Pathways of the Dodecameric Ferritin-like Protein Dps. Inorg.Chem., 58, 2019
1YDT	STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH H89 PROTEIN KINASE INHIBITOR N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE 分子名称: C-AMP-DEPENDENT PROTEIN KINASE, N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE, PROTEIN KINASE INHIBITOR PEPTIDE 著者 Engh, R.A, Girod, A, Kinzel, V, Huber, R, Bossemeyer, D. 登録日 1996-07-24 公開日 1997-04-01 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity. J.Biol.Chem., 271, 1996
2CB9	Crystal structure of the thioesterase domain of the fengycin biosynthesis cluster 分子名称: ACETIC ACID, FENGYCIN SYNTHETASE 著者 Samel, S, Marahiel, M.A, Essen, L.-O. 登録日 2006-01-03 公開日 2007-03-06 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The Thioesterase Domain of the Fengycin Biosynthesis Cluster: A Structural Base for the Macrocyclization of a Non-Ribosomal Lipopeptide J.Mol.Biol., 359, 2006
1YDS	Structure of CAMP-dependent protein kinase, alpha-catalytic subunit in complex with H8 protein kinase inhibitor [N-(2-methylamino)ethyl]-5-isoquinolinesulfonamide 分子名称: C-AMP-DEPENDENT PROTEIN KINASE, N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE, PROTEIN KINASE INHIBITOR PEPTIDE 著者 Engh, R.A, Girod, A, Kinzel, V, Huber, R, Bossemeyer, D. 登録日 1996-07-24 公開日 1997-04-01 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity. J.Biol.Chem., 271, 1996
1A15	SDF-1ALPHA 分子名称: STROMAL DERIVED FACTOR-1ALPHA, SULFATE ION 著者 Dealwis, C.G, Fernandez, E.J, Lolis, E. 登録日 1997-12-22 公開日 1998-08-12 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of chemically synthesized [N33A] stromal cell-derived factor 1alpha, a potent ligand for the HIV-1 "fusin" coreceptor. Proc.Natl.Acad.Sci.USA, 95, 1998
2C9N	Structure of the Epstein-Barr virus ZEBRA protein at approximately 3. 5 Angstrom resolution 分子名称: 5'-D(*CP*AP*CP*TP*GP*AP*CP*TP*CP*AP *T)-3', 5'-D(*CP*AP*TP*GP*AP*GP*TP*CP*AP*GP *T)-3', BZLF1 TRANS-ACTIVATOR PROTEIN 著者 Petosa, C, Morand, P, Baudin, F, Moulin, M, Artero, J.B, Muller, C.W. 登録日 2005-12-13 公開日 2006-02-21 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Structural Basis of Lytic Cycle Activation by the Epstein-Barr Virus Zebra Protein Mol.Cell, 21, 2006
1AM6	CARBONIC ANHYDRASE II INHIBITOR: ACETOHYDROXAMATE 分子名称: ACETOHYDROXAMIC ACID, CARBONIC ANHYDRASE, MERCURY (II) ION, ... 著者 Scolnick, L.R, Clements, A.M, Christianson, D.W. 登録日 1997-06-24 公開日 1998-06-24 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Novel Binding Mode of Hydroxamate Inhibitors to Human Carbonic Anhydrase II J.Am.Chem.Soc., 119, 1997
1GX5	Hepatitis C Virus RNA Polymerase in Complex with GTP and Manganese 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE 著者 Bressanelli, S, Rey, F.A. 登録日 2002-03-27 公開日 2002-04-09 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 A Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides J.Virol., 76, 2002
3V5G	Crystal structure of human carbonic anhydrase II in complex with the 4-sulfamido-benzenesulfonamide inhibitor 分子名称: 4-(HYDROXYMERCURY)BENZOIC ACID, 4-(sulfamoylamino)benzenesulfonamide, Carbonic anhydrase 2, ... 著者 D'Ambrosio, K, De Simone, G. 登録日 2011-12-16 公開日 2012-07-25 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups. J.Med.Chem., 55, 2012
1Q8W	The Catalytic Subunit of cAMP-dependent Protein Kinase in Complex with Rho-kinase Inhibitor Fasudil (HA-1077) 分子名称: 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE, cAMP-dependent protein kinase inhibitor, alpha form, ... 著者 Breitenlechner, C, Gassel, M, Hidaka, H, Kinzel, V, Huber, R, Engh, R.A, Bossemeyer, D. 登録日 2003-08-22 公開日 2003-12-16 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity. Structure, 11, 2003
9DFW	X-ray crystal structure of an engineered Viperin-like enzyme from T. virens with bound CTP and SAM 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CYTIDINE-5'-TRIPHOSPHATE, GLYCEROL, ... 著者 Lachowicz, J.C, Bonanno, J.B, Grove, T.L. 登録日 2024-08-30 公開日 2025-02-12 最終更新日 2025-05-28 実験手法 X-RAY DIFFRACTION (1.677 Å) 主引用文献 Structural insights from active site variants and beta-8 loop interactions in viperin-like enzymes. Structure, 2025
6S96	Crystal structure of the catalytic domain of UBE2S C118A. 分子名称: FORMIC ACID, SODIUM ION, Ubiquitin-conjugating enzyme E2 S 著者 Liess, A.K.L, Lorenz, S. 登録日 2019-07-11 公開日 2020-10-21 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S. Sci.Signal., 13, 2020

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