1G79
 
 | | X-RAY STRUCTURE OF ESCHERICHIA COLI PYRIDOXINE 5'-PHOSPHATE OXIDASE COMPLEXED WITH PYRIDOXAL 5'-PHOSPHATE AT 2.0 A RESOLUTION | | 分子名称: | BETA-MERCAPTOETHANOL, FLAVIN MONONUCLEOTIDE, PHOSPHATE ION, ... | | 著者 | Safo, M.K, Musayev, F.N, di Salvo, M.L, Schirch, V. | | 登録日 | 2000-11-09 | | 公開日 | 2000-11-29 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | X-ray structure of Escherichia coli pyridoxine 5'-phosphate oxidase complexed with pyridoxal 5'-phosphate at 2.0 A resolution.
J.Mol.Biol., 310, 2001
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2BND
 | | The structure of E. coli UMP kinase in complex with UDP | | 分子名称: | GLYCEROL, PYROPHOSPHATE 2-, URIDINE-5'-DIPHOSPHATE, ... | | 著者 | Briozzo, P, Evrin, C, Meyer, P, Assairi, L, Joly, N, Barzu, O, Gilles, A.M. | | 登録日 | 2005-03-23 | | 公開日 | 2005-04-27 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure of Escherichia Coli Ump Kinase Differs from that of Other Nucleoside Monophosphate Kinases and Sheds New Light on Enzyme Regulation.
J.Biol.Chem., 280, 2005
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2Z1M
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1NFB
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1FKG
 | | DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12 | | 分子名称: | 1,3-DIPHENYL-1-PROPYL-1-(3,3-DIMETHYL-1,2-DIOXYPENTYL)-2-PIPERIDINE CARBOXYLATE, FK506 BINDING PROTEIN | | 著者 | Holt, D.A, Luengo, J.I, Yamashita, D.S, Oh, H.-J, Konialian, A.L, Yen, H.-K, Rozamus, L.W, Brandt, M, Bossard, M.J, Levy, M.A, Eggleston, D.S, Stout, T.J, Liang, J, Schultz, L.W, Clardy, J. | | 登録日 | 1993-08-05 | | 公開日 | 1994-01-31 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS AND THE X-RAY CRYSTAL-STRUCTURES OF THEIR COMPLEXES WITH FKBP12.
J.Am.Chem.Soc., 115, 1993
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1FKS
 | | SOLUTION STRUCTURE OF FKBP, A ROTAMASE ENZYME AND RECEPTOR FOR FK506 AND RAPAMYCIN | | 分子名称: | FK506 AND RAPAMYCIN-BINDING PROTEIN | | 著者 | Michnick, S.W, Rosen, M.K, Wandless, T.J, Karplus, M, Schreiber, S.L. | | 登録日 | 1992-03-05 | | 公開日 | 1994-01-31 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and rapamycin.
Science, 252, 1991
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1YS4
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2BNF
 | | The structure of E. coli UMP kinase in complex with UTP | | 分子名称: | GLYCEROL, URIDINE 5'-TRIPHOSPHATE, URIDYLATE KINASE | | 著者 | Briozzo, P, Evrin, C, Meyer, P, Assairi, L, Joly, N, Barzu, O, Gilles, A.M. | | 登録日 | 2005-03-23 | | 公開日 | 2005-04-27 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Structure of Escherichia Coli Ump Kinase Differs from that of Other Nucleoside Monophosphate Kinases and Sheds New Light on Enzyme Regulation.
J.Biol.Chem., 280, 2005
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1NSG
 | | THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-RAPAMYCIN COMPLEX INTERACTING WITH HUMAN FRAP | | 分子名称: | C49-METHYL RAPAMYCIN, FK506-BINDING PROTEIN, FKBP-RAPAMYCIN ASSOCIATED PROTEIN (FRAP) | | 著者 | Liang, J, Choi, J, Clardy, J. | | 登録日 | 1997-07-01 | | 公開日 | 1998-03-18 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution.
Acta Crystallogr.,Sect.D, 55, 1999
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2XD4
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1FKJ
 | | ATOMIC STRUCTURE OF FKBP12-FK506, AN IMMUNOPHILIN IMMUNOSUPPRESSANT COMPLEX | | 分子名称: | 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, FK506 BINDING PROTEIN | | 著者 | Wilson, K.P, Sintchak, M.D, Thomson, J.A, Navia, M.A. | | 登録日 | 1995-08-18 | | 公開日 | 1995-12-07 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Comparative X-ray structures of the major binding protein for the immunosuppressant FK506 (tacrolimus) in unliganded form and in complex with FK506 and rapamycin.
Acta Crystallogr.,Sect.D, 51, 1995
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1GFS
 | | GDP-FUCOSE SYNTHETASE FROM E. COLI | | 分子名称: | GDP-FUCOSE SYNTHETASE | | 著者 | Somers, W.S, Stahl, M.L, Sullivan, F.X. | | 登録日 | 1998-08-17 | | 公開日 | 1999-08-17 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | GDP-fucose synthetase from Escherichia coli: structure of a unique member of the short-chain dehydrogenase/reductase family that catalyzes two distinct reactions at the same active site.
Structure, 6, 1998
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1KV8
 | | Crystal Structure of 3-Keto-L-Gulonate 6-Phosphate Decarboxylase | | 分子名称: | 3-Keto-L-Gulonate 6-Phosphate Decarboxylase, MAGNESIUM ION, PHOSPHATE ION | | 著者 | Wise, E, Yew, W.S, Babbitt, P.C, Gerlt, J.A, Rayment, I. | | 登録日 | 2002-01-25 | | 公開日 | 2002-04-15 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | | 主引用文献 | Homologous (beta/alpha)8-barrel enzymes that catalyze unrelated reactions: orotidine 5'-monophosphate decarboxylase and 3-keto-L-gulonate 6-phosphate decarboxylase.
Biochemistry, 41, 2002
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2BNE
 | | The structure of E. coli UMP kinase in complex with UMP | | 分子名称: | GLYCEROL, URIDINE-5'-MONOPHOSPHATE, URIDYLATE KINASE | | 著者 | Briozzo, P, Evrin, C, Meyer, P, Assairi, L, Joly, N, Barzu, O, Gilles, A.M. | | 登録日 | 2005-03-23 | | 公開日 | 2005-04-25 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure of Escherichia Coli Ump Kinase Differs from that of Other Nucleoside Monophosphate Kinases and Sheds New Light on Enzyme Regulation.
J.Biol.Chem., 280, 2005
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1Z9D
 | | Crystal structure of a putative uridylate kinase (UMP-kinase) from Streptococcus pyogenes | | 分子名称: | SULFATE ION, uridylate kinase | | 著者 | Rajashankar, K.R, Kniewel, R, Lee, K, Lima, C.D, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | | 登録日 | 2005-04-01 | | 公開日 | 2005-04-19 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal structure of a putative uridylate kinase (UMP-kinase) from Streptococcus pyogenes
To be Published
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1ZCZ
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2ZW2
 | | Crystal Structure of Formylglycinamide Ribonucleotide Amidotransferase III from SULFOLOBUS TOKODAII (STPURS) | | 分子名称: | GLYCEROL, Putative uncharacterized protein STS178 | | 著者 | Suzuki, S, Tamura, S, Okada, K, Baba, S, Kumasaka, T, Nakagawa, N, Masui, R, Kuramitsu, S, Sampei, G, Kawai, G. | | 登録日 | 2008-11-27 | | 公開日 | 2009-11-17 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Crystal Structure of Formylglycinamide Ribonucleotide Amidotransferase III from SULFOLOBUS TOKODAII (STPURS)
To be Published
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2Z95
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1FXS
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5ZCS
 | | 4.9 Angstrom Cryo-EM structure of human mTOR complex 2 | | 分子名称: | Rapamycin-insensitive companion of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex 2 subunit MAPKAP1, ... | | 著者 | Chen, X, Liu, M, Tian, Y, Wang, H, Wang, J, Xu, Y. | | 登録日 | 2018-02-20 | | 公開日 | 2018-03-21 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | | 主引用文献 | Cryo-EM structure of human mTOR complex 2.
Cell Res., 28, 2018
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6BAC
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6AZU
 | | Holo IDO1 crystal structure | | 分子名称: | Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | | 著者 | Lewis, H.A, Yan, C. | | 登録日 | 2017-09-13 | | 公開日 | 2018-03-21 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.822 Å) | | 主引用文献 | Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6AZV
 | | IDO1/BMS-978587 crystal structure | | 分子名称: | (1R,2S)-2-(4-[bis(2-methylpropyl)amino]-3-{[(4-methylphenyl)carbamoyl]amino}phenyl)cyclopropane-1-carboxylic acid, Indoleamine 2,3-dioxygenase 1 | | 著者 | Lewis, H.A. | | 登録日 | 2017-09-13 | | 公開日 | 2018-03-21 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.755 Å) | | 主引用文献 | Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6BCU
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6BCX
 | | mTORC1 structure refined to 3.0 angstroms | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E-binding protein 1, MAGNESIUM ION, ... | | 著者 | Pavletich, N.P, Yang, H. | | 登録日 | 2017-10-20 | | 公開日 | 2017-12-20 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | | 主引用文献 | Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
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