6AZV

IDO1/BMS-978587 crystal structure

Summary for 6AZV

Entry DOI	10.2210/pdb6azv/pdb
Related	6azu
Descriptor	Indoleamine 2,3-dioxygenase 1, (1R,2S)-2-(4-[bis(2-methylpropyl)amino]-3-{[(4-methylphenyl)carbamoyl]amino}phenyl)cyclopropane-1-carboxylic acid (3 entities in total)
Functional Keywords	ido1 heme-displaced ligand-bound, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm, cytosol : P14902
Total number of polymer chains	4
Total formula weight	182770.25
Authors	Lewis, H.A. (deposition date: 2017-09-13, release date: 2018-03-21, Last modification date: 2023-10-04)
Primary citation	Nelp, M.T.,Kates, P.A.,Hunt, J.T.,Newitt, J.A.,Balog, A.,Maley, D.,Zhu, X.,Abell, L.,Allentoff, A.,Borzilleri, R.,Lewis, H.A.,Lin, Z.,Seitz, S.P.,Yan, C.,Groves, J.T. Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form. Proc. Natl. Acad. Sci. U.S.A., 115:3249-3254, 2018 Cited by PubMed: 29531094 DOI: 10.1073/pnas.1719190115 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.755 Å)

Structure validation