6AZV

IDO1/BMS-978587 crystal structure

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002376	biological_process	immune system process
A	0004833	molecular_function	L-tryptophan 2,3-dioxygenase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006569	biological_process	L-tryptophan catabolic process
A	0007565	biological_process	female pregnancy
A	0009055	molecular_function	electron transfer activity
A	0016491	molecular_function	oxidoreductase activity
A	0019441	biological_process	L-tryptophan catabolic process to kynurenine
A	0019805	biological_process	quinolinate biosynthetic process
A	0020037	molecular_function	heme binding
A	0030485	cellular_component	smooth muscle contractile fiber
A	0032421	cellular_component	stereocilium bundle
A	0033754	molecular_function	indoleamine 2,3-dioxygenase activity
A	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
A	0046006	biological_process	regulation of activated T cell proliferation
A	0046872	molecular_function	metal ion binding
A	0051213	molecular_function	dioxygenase activity
A	0070234	biological_process	positive regulation of T cell apoptotic process
B	0002376	biological_process	immune system process
B	0004833	molecular_function	L-tryptophan 2,3-dioxygenase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006569	biological_process	L-tryptophan catabolic process
B	0007565	biological_process	female pregnancy
B	0009055	molecular_function	electron transfer activity
B	0016491	molecular_function	oxidoreductase activity
B	0019441	biological_process	L-tryptophan catabolic process to kynurenine
B	0019805	biological_process	quinolinate biosynthetic process
B	0020037	molecular_function	heme binding
B	0030485	cellular_component	smooth muscle contractile fiber
B	0032421	cellular_component	stereocilium bundle
B	0033754	molecular_function	indoleamine 2,3-dioxygenase activity
B	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
B	0046006	biological_process	regulation of activated T cell proliferation
B	0046872	molecular_function	metal ion binding
B	0051213	molecular_function	dioxygenase activity
B	0070234	biological_process	positive regulation of T cell apoptotic process
C	0002376	biological_process	immune system process
C	0004833	molecular_function	L-tryptophan 2,3-dioxygenase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006569	biological_process	L-tryptophan catabolic process
C	0007565	biological_process	female pregnancy
C	0009055	molecular_function	electron transfer activity
C	0016491	molecular_function	oxidoreductase activity
C	0019441	biological_process	L-tryptophan catabolic process to kynurenine
C	0019805	biological_process	quinolinate biosynthetic process
C	0020037	molecular_function	heme binding
C	0030485	cellular_component	smooth muscle contractile fiber
C	0032421	cellular_component	stereocilium bundle
C	0033754	molecular_function	indoleamine 2,3-dioxygenase activity
C	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
C	0046006	biological_process	regulation of activated T cell proliferation
C	0046872	molecular_function	metal ion binding
C	0051213	molecular_function	dioxygenase activity
C	0070234	biological_process	positive regulation of T cell apoptotic process
D	0002376	biological_process	immune system process
D	0004833	molecular_function	L-tryptophan 2,3-dioxygenase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006569	biological_process	L-tryptophan catabolic process
D	0007565	biological_process	female pregnancy
D	0009055	molecular_function	electron transfer activity
D	0016491	molecular_function	oxidoreductase activity
D	0019441	biological_process	L-tryptophan catabolic process to kynurenine
D	0019805	biological_process	quinolinate biosynthetic process
D	0020037	molecular_function	heme binding
D	0030485	cellular_component	smooth muscle contractile fiber
D	0032421	cellular_component	stereocilium bundle
D	0033754	molecular_function	indoleamine 2,3-dioxygenase activity
D	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
D	0046006	biological_process	regulation of activated T cell proliferation
D	0046872	molecular_function	metal ion binding
D	0051213	molecular_function	dioxygenase activity
D	0070234	biological_process	positive regulation of T cell apoptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue C4V A 501

Chain	Residue
A	TYR126
A	HIS346
A	ILE349
A	ILE354
A	HOH617
A	CYS129
A	PHE163
A	SER167
A	VAL170
A	GLY262
A	SER263
A	ALA264
A	GLN266

---

site_id	AC2
Number of Residues	9
Details	binding site for residue C4V B 501

Chain	Residue
B	TYR126
B	CYS129
B	PHE163
B	SER167
B	PHE214
B	SER263
B	ALA264
B	HIS346
B	HOH602

---

site_id	AC3
Number of Residues	13
Details	binding site for residue C4V C 501

Chain	Residue
C	TYR126
C	CYS129
C	PHE163
C	VAL166
C	SER167
C	VAL170
C	LEU234
C	SER263
C	ALA264
C	GLN266
C	HIS346
C	ILE349
C	HOH611

---

site_id	AC4
Number of Residues	12
Details	binding site for residue C4V D 501

Chain	Residue
D	TYR126
D	CYS129
D	VAL130
D	PHE163
D	VAL166
D	SER167
D	VAL170
D	PHE214
D	SER263
D	ALA264
D	HIS346
D	ILE349

---

Functional Information from PROSITE/UniProt

site_id	PS00876
Number of Residues	11
Details	IDO_1 Indoleamine 2,3-dioxygenase signature 1. GGSAGQSSvfQ

Chain	Residue	Details
A	GLY261-GLN271

---

site_id	PS00877
Number of Residues	14
Details	IDO_2 Indoleamine 2,3-dioxygenase signature 2. FLQDMrrYMppaHR

Chain	Residue	Details
A	PHE291-ARG304

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"description":"proximal binding residue","evidences":[{"source":"PubMed","id":"16477023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25313323","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2D0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2D0U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PK6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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