1OPL
 
 | | Structural basis for the auto-inhibition of c-Abl tyrosine kinase | | 分子名称: | 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, MYRISTIC ACID, proto-oncogene tyrosine-protein kinase | | 著者 | Nagar, B, Hantschel, O, Young, M.A, Scheffzek, K, Veach, D, Bornmann, W, Clarkson, B, Superti-Furga, G, Kuriyan, J. | | 登録日 | 2003-03-06 | | 公開日 | 2003-04-08 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (3.42 Å) | | 主引用文献 | Structural basis for the autoinhibition of c-Abl tyrosine kinase
Cell(Cambridge,Mass.), 112, 2003
|
|
1OPK
 | | Structural basis for the auto-inhibition of c-Abl tyrosine kinase | | 分子名称: | 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, GLYCEROL, MYRISTIC ACID, ... | | 著者 | Nagar, B, Hantschel, O, Young, M.A, Scheffzek, K, Veach, D, Bornmann, W, Clarkson, B, Superti-Furga, G, Kuriyan, J. | | 登録日 | 2003-03-06 | | 公開日 | 2003-04-08 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural basis for the autoinhibition of c-Abl tyrosine kinase
Cell(Cambridge,Mass.), 112, 2003
|
|
1OPJ
 | | Structural basis for the auto-inhibition of c-Abl tyrosine kinase | | 分子名称: | 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, CHLORIDE ION, MYRISTIC ACID, ... | | 著者 | Nagar, B, Hantschel, O, Young, M.A, Scheffzek, K, Veach, D, Bornmann, W, Clarkson, B, Superti-Furga, G, Kuriyan, J. | | 登録日 | 2003-03-06 | | 公開日 | 2003-04-08 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structural basis for the autoinhibition of c-Abl tyrosine kinase
Cell(Cambridge,Mass.), 112, 2003
|
|
1OEC
 | | FGFr2 kinase domain | | 分子名称: | 4-ARYL-2-PHENYLAMINO PYRIMIDINE, FIBROBLAST GROWTH FACTOR RECEPTOR 2, SULFATE ION | | 著者 | Ceska, T.A, Owens, R, Doyle, C, Hamlyn, P, Crabbe, T, Moffat, D, Davis, J, Martin, R, Perry, M.J. | | 登録日 | 2003-03-24 | | 公開日 | 2004-10-27 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The Crystal Structure of the Fgfr2 Tyrosine Kinase Domain in Complex with 4-Aryl-2-Phenylamino Pyrimidine Angiogenesis Inhibitors
To be Published
|
|
1MQB
 | | Crystal Structure of Ephrin A2 (ephA2) Receptor Protein Kinase | | 分子名称: | Ephrin type-A receptor 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | 著者 | Nowakowski, J, Cronin, C.N, McRee, D.E, Knuth, M.W, Nelson, C, Pavletich, N, Rogers, J, Sang, B.C, Scheibe, D.N, Swanson, R.V, Thompson, D.A. | | 登録日 | 2002-09-16 | | 公開日 | 2003-09-16 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structures of the Cancer Related Aurora-A, FAK and EphA2 Protein Kinases from Nanovolume Crystallography
Structure, 10, 2003
|
|
1MP8
 | | Crystal structure of Focal Adhesion Kinase (FAK) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, focal adhesion kinase 1 | | 著者 | Nowakowski, J, Cronin, C.N, McRee, D.E, Knuth, M.W, Nelson, C.G, Pavletich, N.P, Rodgers, J, Sang, B.-C, Scheibe, D.N, Swanson, R.V, Thompson, D.A. | | 登録日 | 2002-09-11 | | 公開日 | 2003-09-16 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography
Structure, 10, 2002
|
|
1M7N
 | |
1M52
 | | Crystal Structure of the c-Abl Kinase domain in complex with PD173955 | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-(2,6-DICHLORO-PHENYL)-8-METHYL-2-(3-METHYLSULFANYL-PHENYLAMINO)-8H-PYRIDO[2,3-D]PYRIMIDIN-7-ONE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1 | | 著者 | Nagar, B, Bornmann, W, Pellicena, P, Schindler, T, Veach, D, Miller, W.T, Clarkson, B, Kuriyan, J. | | 登録日 | 2002-07-08 | | 公開日 | 2002-09-18 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystal Structures of the Kinase Domain of c-Abl in Complex with the Small Molecule Inhibitors PD173955 and Imatinib (STI-571)
Cancer Res., 62, 2002
|
|
1M17
 | |
1M14
 | |
1LUF
 | | Crystal Structure of the MuSK Tyrosine Kinase: Insights into Receptor Autoregulation | | 分子名称: | muscle-specific tyrosine kinase receptor musk | | 著者 | Till, J.H, Becerra, M, Watty, A, Lu, Y, Ma, Y, Neubert, T.A, Burden, S.J, Hubbard, S.R. | | 登録日 | 2002-05-22 | | 公開日 | 2002-09-11 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Crystal structure of the MuSK tyrosine kinase: insights into receptor autoregulation.
Structure, 10, 2002
|
|
1KSW
 | | Structure of Human c-Src Tyrosine Kinase (Thr338Gly Mutant) in Complex with N6-benzyl ADP | | 分子名称: | N6-BENZYL ADENOSINE-5'-DIPHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC | | 著者 | Witucki, L.A, Huang, X, Shah, K, Liu, Y, Kyin, S, Eck, M.J, Shokat, K.M. | | 登録日 | 2002-01-14 | | 公開日 | 2002-02-27 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme.
Chem.Biol., 9, 2002
|
|
1K9A
 | | Crystal structure analysis of full-length carboxyl-terminal Src kinase at 2.5 A resolution | | 分子名称: | Carboxyl-terminal Src kinase | | 著者 | Ogawa, A, Takayama, Y, Nagata, A, Chong, K.T, Takeuchi, S, Sakai, H, Nakagawa, A, Nada, S, Okada, M, Tsukihara, T. | | 登録日 | 2001-10-28 | | 公開日 | 2002-03-20 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure of the carboxyl-terminal Src kinase, Csk.
J.Biol.Chem., 277, 2002
|
|
1K3A
 | | Structure of the Insulin-like Growth Factor 1 Receptor Kinase | | 分子名称: | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, insulin receptor substrate 1, insulin-like growth factor 1 receptor | | 著者 | Favelyukis, S, Till, J.H, Hubbard, S.R, Miller, W.T. | | 登録日 | 2001-10-02 | | 公開日 | 2001-11-28 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structure and autoregulation of the insulin-like growth factor 1 receptor kinase.
Nat.Struct.Biol., 8, 2001
|
|
1K2P
 | | Crystal structure of Bruton's tyrosine kinase domain | | 分子名称: | Tyrosine-protein kinase BTK | | 著者 | Mao, C, Zhou, M, Uckun, F.M. | | 登録日 | 2001-09-28 | | 公開日 | 2002-06-26 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemia.
J.Biol.Chem., 276, 2001
|
|
1JQH
 | | IGF-1 receptor kinase domain | | 分子名称: | IGF-1 receptor kinase, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | 著者 | Pautsch, A, Zoephel, A, Ahorn, H, Spevak, W, Hauptmann, R, Nar, H. | | 登録日 | 2001-08-07 | | 公開日 | 2002-04-19 | | 最終更新日 | 2021-11-10 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of bisphosphorylated IGF-1 receptor kinase: insight into domain movements upon kinase activation.
Structure, 9, 2001
|
|
1JPA
 | | Crystal Structure of unphosphorylated EphB2 receptor tyrosine kinase and juxtamembrane region | | 分子名称: | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, neural kinase, Nuk=Eph/Elk/Eck family receptor-like tyrosine kinase | | 著者 | Wybenga-Groot, L.E, Pawson, T, Sicheri, F. | | 登録日 | 2001-08-01 | | 公開日 | 2001-10-03 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region.
Cell(Cambridge,Mass.), 106, 2001
|
|
1IRK
 | | CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HUMAN INSULIN RECEPTOR | | 分子名称: | ETHYL MERCURY ION, INSULIN RECEPTOR TYROSINE KINASE DOMAIN | | 著者 | Hubbard, S.R, Wei, L, Ellis, L, Hendrickson, W.A. | | 登録日 | 1995-01-02 | | 公開日 | 1995-02-27 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of the tyrosine kinase domain of the human insulin receptor.
Nature, 372, 1994
|
|
1IR3
 | |
1IEP
 | | CRYSTAL STRUCTURE OF THE C-ABL KINASE DOMAIN IN COMPLEX WITH STI-571. | | 分子名称: | 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, CHLORIDE ION, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL | | 著者 | Nagar, B, Bornmann, W, Schindler, T, Clarkson, B, Kuriyan, J. | | 登録日 | 2001-04-10 | | 公開日 | 2001-04-18 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571)
Cancer Res., 62, 2002
|
|
1I44
 | | CRYSTALLOGRAPHIC STUDIES OF AN ACTIVATION LOOP MUTANT OF THE INSULIN RECEPTOR TYROSINE KINASE | | 分子名称: | INSULIN RECEPTOR, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | | 著者 | Till, J.H, Ablooglu, A.J, Frankel, M, Kohanski, R.A, Hubbard, S.R. | | 登録日 | 2001-02-19 | | 公開日 | 2001-03-07 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanism.
J.Biol.Chem., 276, 2001
|
|
1GJO
 | | The FGFr2 tyrosine kinase domain | | 分子名称: | FIBROBLAST GROWTH FACTOR RECEPTOR 2, SULFATE ION | | 著者 | Ceska, T.A, Owens, R, Doyle, C, Hamlyn, P, Crabbe, T, Moffat, D, Davis, J, Martin, R, Perry, M.J. | | 登録日 | 2001-07-31 | | 公開日 | 2003-08-15 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The Fgfr2 Tyrosine Kinase Domain
To be Published
|
|
1GAG
 | | CRYSTAL STRUCTURE OF THE INSULIN RECEPTOR KINASE IN COMPLEX WITH A BISUBSTRATE INHIBITOR | | 分子名称: | BISUBSTRATE PEPTIDE INHIBITOR, INSULIN RECEPTOR, TYROSINE KINASE DOMAIN, ... | | 著者 | Parang, K, Till, J.H, Ablooglu, A.J, Kohanski, R.A, Hubbard, S.R, Cole, P.A. | | 登録日 | 2000-11-29 | | 公開日 | 2001-01-17 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Mechanism-based design of a protein kinase inhibitor.
Nat.Struct.Biol., 8, 2001
|
|
1FVR
 | | TIE2 KINASE DOMAIN | | 分子名称: | TYROSINE-PROTEIN KINASE TIE-2 | | 著者 | Shewchuk, L.M, Hassell, A.M, Ellis, B, Holmes, W.D, Davis, R, Horne, E.L, Kadwell, S.H, McKee, D.D, Moore, J.T. | | 登録日 | 2000-09-20 | | 公開日 | 2001-09-20 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail.
Structure Fold.Des., 8, 2000
|
|
1FPU
 | | CRYSTAL STRUCTURE OF ABL KINASE DOMAIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR | | 分子名称: | N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]PHENYL]-3-PYRIDINECARBOXAMIDE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL | | 著者 | Schindler, T, Bornmann, W, Pellicena, P, Miller, W.T, Clarkson, B, Kuriyan, J. | | 登録日 | 2000-08-31 | | 公開日 | 2000-09-20 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural mechanism for STI-571 inhibition of abelson tyrosine kinase.
Science, 289, 2000
|
|
