6P0D
 
 | | Human DNA Ligase 1 (E346A/E592A) Bound to an Adenylated, hydroxyl terminated DNA nick | | 分子名称: | ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), ... | | 著者 | Schellenberg, M.J, Williams, R.S, Tumbale, P.S, Riccio, A.A. | | 登録日 | 2019-05-16 | | 公開日 | 2019-12-11 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Two-tiered enforcement of high-fidelity DNA ligation.
Nat Commun, 10, 2019
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6P0C
 | | Human DNA Ligase 1 Bound to an Adenylated, hydroxyl terminated DNA nick in EDTA | | 分子名称: | ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), ... | | 著者 | Schellenberg, M.J, Tumbale, P.S, Riccio, A.A, Williams, R.S. | | 登録日 | 2019-05-16 | | 公開日 | 2019-12-11 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Two-tiered enforcement of high-fidelity DNA ligation.
Nat Commun, 10, 2019
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6P09
 | | Human DNA Ligase 1 Bound to an Adenylated, dideoxy Terminated DNA nick with 200 mM Mg2+ | | 分子名称: | ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), ... | | 著者 | Schellenberg, M.J, Williams, R.S, Tumbale, P.S, Riccio, A.A. | | 登録日 | 2019-05-16 | | 公開日 | 2019-12-11 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.052 Å) | | 主引用文献 | Two-tiered enforcement of high-fidelity DNA ligation.
Nat Commun, 10, 2019
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6P0E
 | | Human DNA Ligase 1 (E346A,E592A) bound to adenylated DNA containing an 8-oxo guanine:adenine base-pair | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Schellenberg, M.J, Williams, R.S, Tumbale, P.S, Riccio, A.A. | | 登録日 | 2019-05-16 | | 公開日 | 2019-12-11 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Two-tiered enforcement of high-fidelity DNA ligation.
Nat Commun, 10, 2019
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6Q1V
 | | Human DNA Ligase 1 (E592R) Bound to an Adenylated, hydroxyl terminated DNA nick | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, ADENOSINE MONOPHOSPHATE, ... | | 著者 | Schellenberg, M.J, Williams, R.S, Tumbale, P.S, Riccio, A.A. | | 登録日 | 2019-08-06 | | 公開日 | 2019-12-11 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Two-tiered enforcement of high-fidelity DNA ligation.
Nat Commun, 10, 2019
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6OFB
 | | Crystal structure of human glutamine-dependent NAD+ synthetase complexed with NaAD+, AMP, pyrophosphate, and Mg2+ | | 分子名称: | ADENOSINE MONOPHOSPHATE, CHLORIDE ION, Glutamine-dependent NAD(+) synthetase, ... | | 著者 | Chuenchor, W, Doukov, T.I, Gerratana, B. | | 登録日 | 2019-03-28 | | 公開日 | 2020-01-08 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | | 主引用文献 | Different ways to transport ammonia in human and Mycobacterium tuberculosis NAD+synthetases.
Nat Commun, 11, 2020
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8UW9
 | | Structure of AKT1(E17K) with compound 4 | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, N-({4-[(2P)-2-(2-aminopyridin-3-yl)-5-phenyl-3H-imidazo[4,5-b]pyridin-3-yl]phenyl}methyl)-2-(2-fluoro-4-formyl-3-hydroxyphenyl)acetamide, ... | | 著者 | Craven, G.B, Taunton, J. | | 登録日 | 2023-11-06 | | 公開日 | 2024-09-04 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Mutant-selective AKT1 inhibitors via lysine targeting and neo-zinc chelation
To Be Published
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8UVY
 | | Structure of AKT1(E17K) with compound 3 | | 分子名称: | 1,2-ETHANEDIOL, 4-{2-[({4-[(2P)-2-(2-aminopyridin-3-yl)-5-phenyl-3H-imidazo[4,5-b]pyridin-3-yl]phenyl}methyl)amino]ethyl}-2-hydroxybenzaldehyde, NB41, ... | | 著者 | Craven, G.B, Taunton, J. | | 登録日 | 2023-11-05 | | 公開日 | 2024-09-04 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | Mutant-selective AKT1 inhibitors via lysine targeting and neo-zinc chelation
To Be Published
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8UW7
 | | Structure of AKT1(WT) with compound 3 | | 分子名称: | 1,2-ETHANEDIOL, 4-{2-[({4-[(2P)-2-(2-aminopyridin-3-yl)-5-phenyl-3H-imidazo[4,5-b]pyridin-3-yl]phenyl}methyl)amino]ethyl}-2-hydroxybenzaldehyde, NB41, ... | | 著者 | Craven, G.B, Taunton, J. | | 登録日 | 2023-11-06 | | 公開日 | 2024-09-04 | | 実験手法 | X-RAY DIFFRACTION (1.972 Å) | | 主引用文献 | Mutant-selective AKT1 inhibitors via lysine targeting and neo-zinc chelation
To Be Published
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6P0B
 | | Human DNA Ligase 1 (E346A/E592A) Bound to an Adenylated, dideoxy Terminated DNA nick with 200 mM Mg2+ | | 分子名称: | ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), ... | | 著者 | Schellenberg, M.J, Williams, R.S, Tumbale, P.S, Riccio, A.A. | | 登録日 | 2019-05-16 | | 公開日 | 2019-12-11 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.203 Å) | | 主引用文献 | Two-tiered enforcement of high-fidelity DNA ligation.
Nat Commun, 10, 2019
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3N6R
 | | CRYSTAL STRUCTURE OF the holoenzyme of PROPIONYL-COA CARBOXYLASE (PCC) | | 分子名称: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Propionyl-CoA carboxylase, alpha subunit, ... | | 著者 | Huang, C.S, Sadre-Bazzaz, K, Tong, L. | | 登録日 | 2010-05-26 | | 公開日 | 2010-08-25 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Crystal structure of the alpha(6)beta(6) holoenzyme of propionyl-coenzyme A carboxylase.
Nature, 466, 2010
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8Q3I
 | | Mycobacterium smegmatis RNA polymerase in complex with HelD, SigA and RbpA in State I | | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | 著者 | Koval, T, Krasny, L, Dohnalek, J, Kouba, T. | | 登録日 | 2023-08-04 | | 公開日 | 2024-08-14 | | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | | 主引用文献 | Molecular insights into RNA polymerase recycling by mycobacterial HelD
To Be Published
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7PN0
 | | Crystal structure of the Phosphorybosylpyrophosphate synthetase II from Thermus thermophilus at R32 space group | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Ribose-phosphate pyrophosphokinase, SULFATE ION | | 著者 | Timofeev, V.I, Abramchik, Y.A, Kostromina, M.A, Esipov, R.S, Kuranova, I.P. | | 登録日 | 2021-09-04 | | 公開日 | 2021-09-29 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Crystal structure of the Phosphorybosylpyrophosphate synthetase II from Thermus thermophilus at R32 space group
To Be Published
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7SXE
 | | Crystal structure of ligase I with nick duplexes containing cognate G:T | | 分子名称: | ADENOSINE MONOPHOSPHATE, DNA chain 1, DNA chain 2, ... | | 著者 | Tang, Q, Gulkis, M, McKenna, R, Caglayan, M. | | 登録日 | 2021-11-22 | | 公開日 | 2022-07-13 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structures of LIG1 that engage with mutagenic mismatches inserted by pol beta in base excision repair.
Nat Commun, 13, 2022
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7SX5
 | | Crystal structure of ligase I with nick duplexes containing mismatch A:C | | 分子名称: | ADENOSINE MONOPHOSPHATE, DNA chain 1, DNA chain 2, ... | | 著者 | Tang, Q, Gulkis, M, McKenna, R, Caglayan, M. | | 登録日 | 2021-11-22 | | 公開日 | 2022-07-13 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structures of LIG1 that engage with mutagenic mismatches inserted by pol beta in base excision repair.
Nat Commun, 13, 2022
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7SUM
 | | Crystal structure of human ligase I with nick duplexes containing cognate A:T | | 分子名称: | ADENOSINE MONOPHOSPHATE, DNA ligase 1, DNA(5'-*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*A-3'), ... | | 著者 | Tang, Q, Gulkis, M, McKenna, R, Caglayan, M. | | 登録日 | 2021-11-17 | | 公開日 | 2022-07-13 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structures of LIG1 that engage with mutagenic mismatches inserted by pol beta in base excision repair.
Nat Commun, 13, 2022
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6BKG
 | | Human LigIV catalytic domain with bound DNA-adenylate intermediate in closed conformation | | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE MONOPHOSPHATE, CHLORIDE ION, ... | | 著者 | Moon, A.F, Tumbale, P.P, Schellenberg, M.J, Williams, R.S, Williams, J.G, Kunkel, T.A, Pedersen, L.C, Bebenek, B. | | 登録日 | 2017-11-08 | | 公開日 | 2018-07-18 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.402 Å) | | 主引用文献 | Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis.
Nat Commun, 9, 2018
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6BKF
 | | Lysyl-adenylate form of human LigIV catalytic domain with bound DNA substrate in open conformation | | 分子名称: | ADENOSINE MONOPHOSPHATE, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), DNA (5'-D(*GP*TP*CP*CP*GP*AP*CP*GP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... | | 著者 | Moon, A.F, Tumbale, P.P, Schellenberg, M.J, Williams, R.S, Williams, J.G, Kunkel, T.A, Pedersen, L.C, Bebenek, B. | | 登録日 | 2017-11-08 | | 公開日 | 2018-07-18 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | | 主引用文献 | Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis.
Nat Commun, 9, 2018
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3O3N
 | | (R)-2-hydroxyisocaproyl-CoA dehydratase in complex with its substrate (R)-2-hydroxyisocaproyl-CoA | | 分子名称: | HYDROSULFURIC ACID, IRON/SULFUR CLUSTER, S-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl ]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethyl] (2R)-2-hydroxy-4-methyl-pentanethioate, ... | | 著者 | Knauer, S.H, Buckel, W, Dobbek, H. | | 登録日 | 2010-07-25 | | 公開日 | 2011-03-16 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural Basis for Reductive Radical Formation and Electron Recycling in (R)-2-Hydroxyisocaproyl-CoA Dehydratase.
J.Am.Chem.Soc., 133, 2011
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8PR0
 | | Cytoplasmic dynein-A heavy chain bound to dynactin-p150glued and IC-LC tower | | 分子名称: | Cytoplasmic dynein 1 heavy chain 1, Cytoplasmic dynein 1 intermediate chain 2, Cytoplasmic dynein 1 light intermediate chain 2, ... | | 著者 | Singh, K, Lau, C.K, Manigrasso, G, Gassmann, R, Carter, A.P. | | 登録日 | 2023-07-12 | | 公開日 | 2024-03-27 | | 最終更新日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (9.4 Å) | | 主引用文献 | Molecular mechanism of dynein-dynactin complex assembly by LIS1.
Science, 383, 2024
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8PR1
 | | Cytoplasmic dynein-B heavy chain bound to IC-LC tower | | 分子名称: | Cytoplasmic dynein 1 heavy chain 1, Cytoplasmic dynein 1 intermediate chain 2, Cytoplasmic dynein 1 light intermediate chain 2, ... | | 著者 | Singh, K, Lau, C.K, Manigrasso, G, Gassmann, R, Carter, A.P. | | 登録日 | 2023-07-12 | | 公開日 | 2024-03-27 | | 最終更新日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (8.2 Å) | | 主引用文献 | Molecular mechanism of dynein-dynactin complex assembly by LIS1.
Science, 383, 2024
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4WJ3
 | | Crystal structure of the asparagine transamidosome from Pseudomonas aeruginosa | | 分子名称: | 76mer-tRNA, Aspartate--tRNA(Asp/Asn) ligase, Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, ... | | 著者 | Suzuki, T, Nakamura, A, Kato, K, Tanaka, I, Yao, M. | | 登録日 | 2014-09-29 | | 公開日 | 2014-12-31 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (3.705 Å) | | 主引用文献 | Structure of the Pseudomonas aeruginosa transamidosome reveals unique aspects of bacterial tRNA-dependent asparagine biosynthesis
Proc.Natl.Acad.Sci.USA, 112, 2015
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6RK5
 | | Inter-dimeric interface controls function and stability of S-methionine adenosyltransferase from U. urealiticum | | 分子名称: | Methionine adenosyltransferase | | 著者 | Shahar, A, Zarivach, R, Bershtein, S, Kleiner, D, Shmulevich, F. | | 登録日 | 2019-04-30 | | 公開日 | 2019-09-25 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The interdimeric interface controls function and stability of Ureaplasma urealiticum methionine S-adenosyltransferase.
J.Mol.Biol., 431, 2019
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6RK7
 | | Inter-dimeric interface controls function and stability of S-methionine adenosyltransferase from U. urealiticum | | 分子名称: | CHLORIDE ION, Methionine adenosyltransferase, S-ADENOSYLMETHIONINE | | 著者 | Shahar, A, Zarivach, R, Bershtein, S, Kleiner, D, Shmulevich, F. | | 登録日 | 2019-04-30 | | 公開日 | 2019-09-25 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The interdimeric interface controls function and stability of Ureaplasma urealiticum methionine S-adenosyltransferase.
J.Mol.Biol., 431, 2019
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1DKU
 | | CRYSTAL STRUCTURES OF BACILLUS SUBTILIS PHOSPHORIBOSYLPYROPHOSPHATE SYNTHETASE: MOLECULAR BASIS OF ALLOSTERIC INHIBITION AND ACTIVATION. | | 分子名称: | METHYL PHOSPHONIC ACID ADENOSINE ESTER, PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, PROTEIN (PHOSPHORIBOSYL PYROPHOSPHATE SYNTHETASE) | | 著者 | Eriksen, T.A, Kadziola, A, Bentsen, A.-K, Harlow, K.W, Larsen, S. | | 登録日 | 1999-12-08 | | 公開日 | 2000-04-05 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural basis for the function of Bacillus subtilis phosphoribosyl-pyrophosphate synthetase.
Nat.Struct.Biol., 7, 2000
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