6P0D

Human DNA Ligase 1 (E346A/E592A) Bound to an Adenylated, hydroxyl terminated DNA nick

Summary for 6P0D

• Entry DOI: 10.2210/pdb6p0d/pdb
• Descriptor: DNA ligase 1, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), DNA (5'-D(P*GP*TP*CP*GP*GP*AP*C)-3'), ... (7 entities in total)
• Functional Keywords: protein-dna complex, phosphotransferase, ob fold, dna binding domain, adenylation domain, metalloenzyme, ligase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 83113.45

Authors

Schellenberg, M.J.,Williams, R.S.,Tumbale, P.S.,Riccio, A.A. (deposition date: 2019-05-16, release date: 2019-12-11, Last modification date: 2023-10-11)

• Primary citation: Tumbale, P.P.,Jurkiw, T.J.,Schellenberg, M.J.,Riccio, A.A.,O'Brien, P.J.,Williams, R.S.; Two-tiered enforcement of high-fidelity DNA ligation.; Nat Commun, 10:5431-5431, 2019; PubMed: 31780661; DOI: 10.1038/s41467-019-13478-7

Experimental method

X-RAY DIFFRACTION (1.75 Å)