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6P0D

Human DNA Ligase 1 (E346A/E592A) Bound to an Adenylated, hydroxyl terminated DNA nick

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0003909molecular_functionDNA ligase activity
A0003910molecular_functionDNA ligase (ATP) activity
A0005524molecular_functionATP binding
A0006281biological_processDNA repair
A0006310biological_processDNA recombination
A0071897biological_processDNA biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues3
Detailsbinding site for residue PEG A 1001
ChainResidue
AALA483
ALYS487
ATRP495

site_idAC2
Number of Residues16
Detailsbinding site for residue AMP C 101
ChainResidue
APHE660
AMET723
ALYS725
ATRP742
ALYS744
ALYS746
AHOH1172
CDG1
CHOH201
CHOH204
AGLU566
ATYR567
ALYS568
ATYR569
AARG573
AGLU621

Functional Information from PROSITE/UniProt
site_idPS00333
Number of Residues27
DetailsDNA_LIGASE_A2 ATP-dependent DNA ligase signature 2. EGLMVKtldvdat.YEiakrs.Hnwl..KLK
ChainResidueDetails
AGLU720-LYS746

site_idPS00697
Number of Residues9
DetailsDNA_LIGASE_A1 ATP-dependent DNA ligase AMP-binding site. EYKYDGQRA
ChainResidueDetails
AGLU566-ALA574

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: N6-AMP-lysine intermediate => ECO:0000255|PROSITE-ProRule:PRU10135
ChainResidueDetails
ALYS568

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:15565146, ECO:0007744|PDB:1X9N
ChainResidueDetails
AGLU566
AARG573
ALYS725
ALYS744

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
AGLU621
AGLU720

site_idSWS_FT_FI4
Number of Residues4
DetailsSITE: Interaction with target DNA
ChainResidueDetails
AARG305
AASN590
ALYS770
ALYS795

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR798

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER801
ASER819

223166

PDB entries from 2024-07-31

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