6Q1V

Human DNA Ligase 1 (E592R) Bound to an Adenylated, hydroxyl terminated DNA nick

Summary for 6Q1V

• Entry DOI: 10.2210/pdb6q1v/pdb
• Related: 6P0C
• Descriptor: DNA ligase 1, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), DNA (5'-D(P*GP*TP*CP*GP*GP*AP*C)-3'), ... (9 entities in total)
• Functional Keywords: protein-dna complex, phosphotransferase, ob fold, dna binding domain, adenylation domain, metalloenzyme, ligase, ligase-dna complex, ligase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 83438.81

Authors

Schellenberg, M.J.,Williams, R.S.,Tumbale, P.S.,Riccio, A.A. (deposition date: 2019-08-06, release date: 2019-12-11, Last modification date: 2023-10-11)

• Primary citation: Tumbale, P.P.,Jurkiw, T.J.,Schellenberg, M.J.,Riccio, A.A.,O'Brien, P.J.,Williams, R.S.; Two-tiered enforcement of high-fidelity DNA ligation.; Nat Commun, 10:5431-5431, 2019; PubMed: 31780661; DOI: 10.1038/s41467-019-13478-7

Experimental method

X-RAY DIFFRACTION (1.85 Å)