6P0E
Human DNA Ligase 1 (E346A,E592A) bound to adenylated DNA containing an 8-oxo guanine:adenine base-pair
Summary for 6P0E
Entry DOI | 10.2210/pdb6p0e/pdb |
Descriptor | DNA ligase 1, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*(8OG))-3'), DNA (5'-D(P*GP*TP*CP*GP*GP*AP*C)-3'), ... (8 entities in total) |
Functional Keywords | protein-dna complex, phosphotransferase, ob fold, dna binding domain, adenylation domain, metalloenzyme, ligase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 83397.77 |
Authors | Schellenberg, M.J.,Williams, R.S.,Tumbale, P.S.,Riccio, A.A. (deposition date: 2019-05-16, release date: 2019-12-11, Last modification date: 2023-10-11) |
Primary citation | Tumbale, P.P.,Jurkiw, T.J.,Schellenberg, M.J.,Riccio, A.A.,O'Brien, P.J.,Williams, R.S. Two-tiered enforcement of high-fidelity DNA ligation. Nat Commun, 10:5431-5431, 2019 Cited by PubMed: 31780661DOI: 10.1038/s41467-019-13478-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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