5H58
 
 | | Structural and dynamics studies of the TetR family protein, CprB from Streptomyces coelicolor in complex with its biological operator sequence | | 分子名称: | CprB, DNA (5'-D(*AP*GP*GP*C*AP*GP*GP*CP*GP*GP*CP*AP*CP*GP*GP*TP*CP*TP*GP*TP*TP*GP*AP*GP*TP*TP*C)-3'), DNA (5'-D(*GP*AP*A*CP*TP*CP*AP*AP*CP*AP*GP*AP*CP*CP*GP*TP*GP*CP*CP*GP*CP*CP*TP*GP*CP*CP*T)-3') | | 著者 | Bhukya, H, Jana, A.K, Sengupta, N, Anand, R. | | 登録日 | 2016-11-04 | | 公開日 | 2017-05-03 | | 最終更新日 | 2017-05-31 | | 実験手法 | X-RAY DIFFRACTION (3.991 Å) | | 主引用文献 | Structural and dynamics studies of the TetR family protein, CprB from Streptomyces coelicolor in complex with its biological operator sequence
J. Struct. Biol., 198, 2017
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3KMC
 | | Crystal structure of catalytic domain of TACE with tartrate-based inhibitor | | 分子名称: | (2R,3R)-4-[4-(2-chlorophenyl)piperazin-1-yl]-2,3-dihydroxy-4-oxo-N-(2-thiophen-2-ylethyl)butanamide, N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide, TNF-alpha-converting enzyme, ... | | 著者 | Orth, P. | | 登録日 | 2009-11-10 | | 公開日 | 2009-12-22 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The discovery of novel tartrate-based TNF-alpha converting enzyme (TACE) inhibitors.
Bioorg.Med.Chem.Lett., 20, 2009
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5GRE
 | | Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with Mg(2+), citrate and ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CITRIC ACID, Isocitrate dehydrogenase [NAD] subunit alpha, ... | | 著者 | Ma, T, Peng, Y, Ding, J. | | 登録日 | 2016-08-11 | | 公開日 | 2017-02-15 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Molecular mechanism of the allosteric regulation of the alpha gamma heterodimer of human NAD-dependent isocitrate dehydrogenase.
Sci Rep, 7, 2017
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5GGQ
 | | Crystal structure of Nivolumab Fab fragment | | 分子名称: | nivolumab heavy chain, nivolumab light chain | | 著者 | Heo, Y.S. | | 登録日 | 2016-06-16 | | 公開日 | 2016-11-09 | | 最終更新日 | 2016-11-16 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy
Nat Commun, 7, 2016
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3L1P
 | | POU protein:DNA complex | | 分子名称: | DNA (5'-D(*AP*TP*CP*CP*AP*TP*TP*TP*GP*CP*CP*TP*TP*TP*CP*AP*AP*AP*TP*GP*TP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*AP*CP*AP*TP*TP*TP*GP*AP*AP*AP*GP*GP*CP*AP*AP*AP*TP*GP*GP*A)-3'), POU domain, ... | | 著者 | Vahokoski, J, Groves, M.R, Pogenberg, V, Wilmanns, M. | | 登録日 | 2009-12-14 | | 公開日 | 2010-12-15 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | A unique Oct4 interface is crucial for reprogramming to pluripotency
Nat.Cell Biol., 15, 2013
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3L24
 | | Crystal Structure of the Nerve Agent Degrading Organophosphate Anhydrolase/Prolidase in Complex with Inhibitors | | 分子名称: | GLYCOLIC ACID, MANGANESE (II) ION, Xaa-Pro dipeptidase | | 著者 | Vyas, N.K, Nichitenko, A, Rastogi, V.K, Shah, S.S, Quiocho, F.A. | | 登録日 | 2009-12-14 | | 公開日 | 2010-01-26 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural insights into the dual activities of the nerve agent degrading organophosphate anhydrolase/prolidase.
Biochemistry, 49, 2010
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5GRQ
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3KMM
 | | Structure of human LCK kinase with a small molecule inhibitor | | 分子名称: | 3-(2,6-dichlorophenyl)-7-({4-[2-(diethylamino)ethoxy]phenyl}amino)-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one, Proto-oncogene tyrosine-protein kinase LCK, SULFATE ION | | 著者 | Graves, B.J, Surgenor, A, Harris, W, Smith, I, Orchard, S, Flotow, H, Murray, E. | | 登録日 | 2009-11-10 | | 公開日 | 2010-12-08 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structure of human LCK kinase with a small molecule inhibitor
To be Published
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5GS1
 | | Crystal structure of homo-specific diabody | | 分子名称: | diabody, heavy chain, light chain | | 著者 | Kim, J.H, Song, D.H, Youn, S.J, Kim, J.W, Cho, G, Lee, H, Lee, J.O. | | 登録日 | 2016-08-13 | | 公開日 | 2016-10-12 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of mono- and bi-specific diabodies and reduction of their structural flexibility by introduction of disulfide bridges at the Fv interface.
Sci Rep, 6, 2016
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5GGY
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3KMU
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5GHB
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7N06
 | | SARS-CoV-2 Nsp15 endoribonuclease post-cleavage state | | 分子名称: | RNA (5'-R(*AP*UP*A)-3'), Uridylate-specific endoribonuclease | | 著者 | Frazier, M.N, Dillard, L.B, Krahn, J.M, Stanley, R.E. | | 登録日 | 2021-05-25 | | 公開日 | 2021-06-02 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | | 主引用文献 | Characterization of SARS2 Nsp15 nuclease activity reveals it's mad about U.
Nucleic Acids Res., 49, 2021
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5GT8
 | | Crystal Structure of apo-CASTOR1 | | 分子名称: | GATS-like protein 3 | | 著者 | Guo, L, Deng, D. | | 登録日 | 2016-08-18 | | 公開日 | 2017-08-23 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal structures of arginine sensor CASTOR1 in arginine-bound and ligand free states
Biochem. Biophys. Res. Commun., 508, 2019
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5GHT
 | | DNA replication protein | | 分子名称: | SsDNA-specific exonuclease | | 著者 | Oyama, T. | | 登録日 | 2016-06-20 | | 公開日 | 2016-10-12 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.795 Å) | | 主引用文献 | Atomic structure of an archaeal GAN suggests its dual roles as an exonuclease in DNA repair and a CMG component in DNA replication.
Nucleic Acids Res., 44, 2016
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3L3G
 | | Crystal structure of HLA-B*4402 in complex with the R5A mutant of a self-peptide derived from DPA*0201 | | 分子名称: | ACETATE ION, Beta-2-microglobulin, GLYCEROL, ... | | 著者 | Theodossis, A, Ely, L.K, Rossjohn, J. | | 登録日 | 2009-12-16 | | 公開日 | 2010-03-16 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition
Proc.Natl.Acad.Sci.USA, 107, 2010
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3KO1
 | | Cystal structure of thermosome from Acidianus tengchongensis strain S5 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Chaperonin | | 著者 | Huo, Y, Zhang, K, Hu, Z, Wang, L, Zhai, Y, Zhou, Q, Lander, G, He, Y, Zhu, J, Xu, W, Dong, Z, Sun, F. | | 登録日 | 2009-11-12 | | 公開日 | 2010-11-03 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | | 主引用文献 | Crystal structure of group II chaperonin in the open state.
Structure, 18, 2010
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5GU2
 | | Crystal structure of Au(M).CL-apo-E45C/R52C-rHLFr | | 分子名称: | 1,2-ETHANEDIOL, CADMIUM ION, Ferritin light chain, ... | | 著者 | Maity, B, Abe, S, Ueno, T. | | 登録日 | 2016-08-24 | | 公開日 | 2017-03-29 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | | 主引用文献 | Observation of gold sub-nanocluster nucleation within a crystalline protein cage
Nat Commun, 8, 2017
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5GI8
 | | Crystal Structure of Drosophila melanogaster Dopamine N-Acetyltransferase in Ternary Complex with CoA and Acetyl-dopamine | | 分子名称: | (4S,5S)-1,2-DITHIANE-4,5-DIOL, COENZYME A, Dopamine N-acetyltransferase, ... | | 著者 | Yang, Y.C, Lin, S.J, Cheng, K.C, Cheng, H.C, Lyu, P.C. | | 登録日 | 2016-06-22 | | 公開日 | 2017-07-05 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Crystal Structure of Drosophila melanogaster Dopamine N-Acetyltransferase in Ternary Complex with CoA and Acetyl-dopamine
To Be Published
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3KPD
 | | Crystal Structure of the CBS domain pair of protein MJ0100 in complex with 5 -methylthioadenosine and S-adenosyl-L-methionine. | | 分子名称: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, S-ADENOSYLMETHIONINE, Uncharacterized protein MJ0100 | | 著者 | Lucas, M, Oyenarte, I, Garcia, I.G, Arribas, E.A, Encinar, J.A, Kortazar, D, Fernandez, J.A, Mato, J.M, Martinez-Chantar, M.L, Martinez-Cruz, L.A. | | 登録日 | 2009-11-16 | | 公開日 | 2010-01-12 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | | 主引用文献 | Binding of S-Methyl-5'-Thioadenosine and S-Adenosyl-l-Methionine to Protein MJ0100 Triggers an Open-to-Closed Conformational Change in Its CBS Motif Pair.
J.Mol.Biol., 396, 2010
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6OIZ
 | | Amyloid-Beta (20-34) wild type | | 分子名称: | Amyloid beta A4 protein | | 著者 | Sawaya, M.R, Warmack, R.A, Zee, C.T, Gonen, T, Clarke, S.G, Eisenberg, D.S. | | 登録日 | 2019-04-10 | | 公開日 | 2019-08-07 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.1 Å) | | 主引用文献 | Structure of amyloid-beta (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface.
Nat Commun, 10, 2019
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5GU9
 | | Structure of biotin carboxyl carrier protein from pyrococcus horikoshi OT3 (delta N79) A138I mutant | | 分子名称: | 149aa long hypothetical methylmalonyl-CoA decarboxylase gamma chain | | 著者 | Yamada, K, Kunishima, N, Matsuura, Y, Nakai, K, Naitow, H, Fukasawa, Y, Tomii, K. | | 登録日 | 2016-08-26 | | 公開日 | 2017-08-30 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Designing better diffracting crystals of biotin carboxyl carrier protein from Pyrococcus horikoshii by a mutation based on the crystal-packing propensity of amino acids.
Acta Crystallogr D Struct Biol, 73, 2017
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3L3R
 | | Structural, Computational and Kinetic Data for Antifolate Interactions Against Pneumocystis jirovecii, Pneumocystis carinii and Human Dihydrofolate Reductase and Their Active Site Mutants | | 分子名称: | 6-{[(2,5-dichlorophenyl)amino]methyl}pyrido[2,3-d]pyrimidine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Cody, V. | | 登録日 | 2009-12-17 | | 公開日 | 2011-01-05 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Kinetic and Structural Analysis for Potent Antifolate Inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and Human Dihydrofolate Reductases and Their Active-Site Variants.
Antimicrob.Agents Chemother., 57, 2013
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7NP7
 | | Structure of an intact ESX-5 inner membrane complex, Composite C1 model | | 分子名称: | ESX-5 secretion system ATPase EccB5, ESX-5 secretion system protein EccC5, ESX-5 secretion system protein EccD5, ... | | 著者 | Fahrenkamp, D, Bunduc, C.M, Wald, J, Ummels, R, Bitter, W, Houben, E.N.G, Marlovits, T.C. | | 登録日 | 2021-02-26 | | 公開日 | 2021-06-02 | | 実験手法 | ELECTRON MICROSCOPY (4.03 Å) | | 主引用文献 | Structure and dynamics of a mycobacterial type VII secretion system.
Nature, 593, 2021
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5GIN
 | | Crystal structure of box C/D RNP with 12 nt guide regions and 9 nt substrates | | 分子名称: | 50S ribosomal protein L7Ae, C/D RNA, C/D box methylation guide ribonucleoprotein complex aNOP56 subunit, ... | | 著者 | Yang, Z, Lin, J, Ye, K. | | 登録日 | 2016-06-24 | | 公開日 | 2016-09-14 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.308 Å) | | 主引用文献 | Box C/D guide RNAs recognize a maximum of 10 nt of substrates
Proc.Natl.Acad.Sci.USA, 113, 2016
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