3KMM

Structure of human LCK kinase with a small molecule inhibitor

Summary for 3KMM

• Entry DOI: 10.2210/pdb3kmm/pdb
• Related: 3LCK
• Descriptor: Proto-oncogene tyrosine-protein kinase LCK, 3-(2,6-dichlorophenyl)-7-({4-[2-(diethylamino)ethoxy]phenyl}amino)-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one, SULFATE ION, ... (4 entities in total)
• Functional Keywords: tyrosine kinase, atp-binding, kinase, nucleotide-binding, phosphoprotein, transferase, tyrosine-protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : P06239
• Total number of polymer chains: 1
• Total formula weight: 34134.64

Authors

Graves, B.J.,Surgenor, A.,Harris, W.,Smith, I.,Orchard, S.,Flotow, H.,Murray, E. (deposition date: 2009-11-10, release date: 2010-12-08, Last modification date: 2023-11-22)

• Primary citation: Graves, B.J.,Surgenor, A.,Harris, W.,Smith, I.,Orchard, S.,Flotow, H.,Murray, E.; Structure of human LCK kinase with a small molecule inhibitor; To be Published,

Experimental method

X-RAY DIFFRACTION (2.8 Å)