PDB: 5425 件ウェブページステータス検索Chemie searchBIRD

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6PGB	WDR5delta32 bound to N-(4-(5-(hydroxymethyl)-1H-imidazol-2-yl)butyl)-2-phenylacetamide 分子名称: N-{4-[5-(hydroxymethyl)-1H-imidazol-2-yl]butyl}-2-phenylacetamide, SULFATE ION, WD repeat-containing protein 5 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PRT	Crystal structure of BRD4 bromodomain 1 with N-methylpyrrolidin-2-one (NMP) derivative 10 (methyl [(3R)-1-methyl-5-oxopyrrolidin-3-yl]acetate) 分子名称: Bromodomain-containing protein 4, methyl [(3R)-1-methyl-5-oxopyrrolidin-3-yl]acetate 著者 Ilyichova, O.V, Scanlon, M.J. 登録日 2019-07-11 公開日 2019-11-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Synthesis and elaboration of N-methylpyrrolidone as an acetamide fragment substitute in bromodomain inhibition. Bioorg.Med.Chem., 27, 2019
6PJJ	Human PRPF4B bound to benzothiophene inhibitor 224 分子名称: 1,2-ETHANEDIOL, 4-(5-{[(3-aminophenyl)methyl]carbamoyl}thiophen-2-yl)-1-benzothiophene-2-carboxamide, PHOSPHATE ION, ... 著者 Godoi, P.H.C, Santiago, A.S, Fala, A.M, Ramos, P.Z, Sriranganadane, D, Mascarello, A, Segretti, N, Azevedo, H, Guimaraes, C.R.W, Arruda, P, Elkins, J.M, Counago, R.M, Structural Genomics Consortium (SGC) 登録日 2019-06-28 公開日 2019-08-28 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 to be published To Be Published
4XW3	Crystal structure of the SPRY domain of the human DEAD-box protein DDX1 分子名称: ATP-dependent RNA helicase DDX1 著者 Kellner, J.N, Meinhart, A. 登録日 2015-01-28 公開日 2015-09-09 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of the SPRY domain of the human RNA helicase DDX1, a putative interaction platform within a DEAD-box protein. Acta Crystallogr.,Sect.F, 71, 2015
4Y03	Crystal Structure of the fifth bromodomain of human PB1 in complex with salicylic acid 分子名称: 2-HYDROXYBENZOIC ACID, CITRIC ACID, Protein polybromo-1 著者 Filippakopoulos, P, Picaud, S, Felletar, I, Fedorov, O, von Delft, F, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2015-02-05 公開日 2015-05-20 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Crystal Structure of the fifth bromodomain of human PB1 in complex with salicylic acid To Be Published
6PF6	Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and 2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)terephthalic acid 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)benzene-1,4-dicarboxylic acid, Thymidylate synthase,Thymidylate synthase 著者 Czyzyk, D.L, Valhondo, M, Jorgensen, W.L, Anderson, K.S. 登録日 2019-06-21 公開日 2019-10-16 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.502 Å) 主引用文献 Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors. Eur.J.Med.Chem., 183, 2019
6PG8	WDR5delta23 bound to (2-(3-phenylpropyl)-1H-imidazol-4-yl)methanol 分子名称: CHLORIDE ION, SULFATE ION, WD repeat-containing protein 5, ... 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
4XY9	Crystal Structure of the first bromodomain of human BRD4 in complex with a 2-amine-9H-purine ligand 分子名称: 1,2-ETHANEDIOL, 6-(5-bromo-2-methoxyphenyl)-9H-purin-2-amine, Bromodomain-containing protein 4 著者 Picaud, S, von Delft, F, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Filippakopoulos, P, Structural Genomics Consortium (SGC) 登録日 2015-02-02 公開日 2015-03-11 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 9H-Purine Scaffold Reveals Induced-Fit Pocket Plasticity of the BRD9 Bromodomain. J.Med.Chem., 58, 2015
6PG4	WDR5delta32 bound to (2-methyl-1H-imidazol-4-yl)methanol 分子名称: (2-methyl-1H-imidazol-4-yl)methanol, SULFATE ION, WD repeat-containing protein 5 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PG9	WDR5delta23 bound to N-(4-(5-(hydroxymethyl)-1H-imidazol-2-yl)butyl)benzamide 分子名称: N-{4-[4-(hydroxymethyl)-1H-imidazol-2-yl]butyl}benzamide, WD repeat-containing protein 5 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
8DEY	Ternary complex structure of Cereblon-DDB1 bound to IKZF2(ZF2,3) and the molecular glue DKY709 分子名称: (3S)-3-[5-(1-benzylpiperidin-4-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, DNA damage-binding protein 1, Protein cereblon, ... 著者 Ma, X, Ornelas, E, Clifton, M.C. 登録日 2022-06-21 公開日 2023-03-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy. Cell Chem Biol, 30, 2023
6PGA	WDR5delta32 bound to methyl (4-(4-(hydroxymethyl)-1H-imidazol-2-yl)butyl)carbamate 分子名称: SULFATE ION, WD repeat-containing protein 5, methyl {4-[5-(hydroxymethyl)-1H-imidazol-2-yl]butyl}carbamate 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PPA	Crystal structure of the unliganded bromodomain of human BRD7 分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 7, PHOSPHATE ION 著者 Chan, A, Karim, M.R, Zhu, J, Schonbrunn, E. 登録日 2019-07-05 公開日 2020-03-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains. J.Med.Chem., 63, 2020
6PAI	Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to RBM39 and sulfonamide E7820 分子名称: 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzene-1-sulfonamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DDB1- and CUL4-associated factor 15, ... 著者 Volkov, O.A, Du, X. 登録日 2019-06-11 公開日 2019-09-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural Basis and Kinetic Pathway of RBM39 Recruitment to DCAF15 by a Sulfonamide Molecular Glue E7820. Structure, 27, 2019
4XYA	Crystal Structure of the first bromodomain of human BRD4 in complex with a 2-amine-9H-purine ligand 分子名称: 1,2-ETHANEDIOL, 6-(5-bromo-1-benzofuran-7-yl)-9H-purin-2-amine, Bromodomain-containing protein 4 著者 Picaud, S, von Delft, F, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Filippakopoulos, P, Structural Genomics Consortium (SGC) 登録日 2015-02-02 公開日 2015-03-11 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 9H-Purine Scaffold Reveals Induced-Fit Pocket Plasticity of the BRD9 Bromodomain. J.Med.Chem., 58, 2015
6PLF	Crystal structure of human PHGDH complexed with Compound 1 分子名称: 1,2-ETHANEDIOL, 4-{(1S)-1-[(5-chloro-6-{[(5S)-2-oxo-1,3-oxazolidin-5-yl]methoxy}-1H-indole-2-carbonyl)amino]-2-hydroxyethyl}benzoic acid, D-3-phosphoglycerate dehydrogenase 著者 Olland, A, Lakshminarasimhan, D, White, A, Suto, R.K. 登録日 2019-06-30 公開日 2019-07-24 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells. Bioorg.Med.Chem.Lett., 29, 2019
6PF5	Crystal structure of human thymidylate synthase Delta (7-29) in complex with dUMP and 2-(2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)-4-methoxyphenyl)acetic acid 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Thymidylate synthase, [2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)-4-methoxyphenyl]acetic acid 著者 Czyzyk, D.J, Valhondo, M, Jorgensen, W.L, Anderson, K.S. 登録日 2019-06-21 公開日 2019-10-02 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors. Eur.J.Med.Chem., 183, 2019
8D7U	Cereblon~DDB1 bound to CC-92480 with DDB1 in the linear conformation 分子名称: DNA damage-binding protein 1, Mezigdomide, Protein cereblon, ... 著者 Watson, E.R, Lander, G.C. 登録日 2022-06-07 公開日 2022-07-20 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Molecular glue CELMoD compounds are regulators of cereblon conformation. Science, 378, 2022
8D81	Cereblon~DDB1 bound to Pomalidomide 分子名称: DNA damage-binding protein 1, Protein cereblon, S-Pomalidomide, ... 著者 Watson, E.R, Lander, G.C. 登録日 2022-06-07 公開日 2022-07-20 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Molecular glue CELMoD compounds are regulators of cereblon conformation. Science, 378, 2022
8D7Y	Cereblon-DDB1 in the Apo form with DDB1 in the twisted conformation 分子名称: DNA damage-binding protein 1, Protein cereblon, ZINC ION 著者 Watson, E.R, Lander, G.C. 登録日 2022-06-07 公開日 2022-07-20 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Molecular glue CELMoD compounds are regulators of cereblon conformation. Science, 378, 2022
4XZF	Crystal structure of HIRAN domain of human HLTF in complex with DNA 分子名称: (DA)(DC)(DC)(DG)(DC)(DC)(DG)(DG)(DG)(DT)(DG)(DC)(DC), Helicase-like transcription factor 著者 Hishiki, A, Hashimoto, H. 登録日 2015-02-04 公開日 2015-04-15 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.38 Å) 主引用文献 Structure of a Novel DNA-binding Domain of Helicase-like Transcription Factor (HLTF) and Its Functional Implication in DNA Damage Tolerance J.Biol.Chem., 290, 2015
8D7W	Cereblon~DDB1 bound to CC-92480 with DDB1 in the hinged conformation 分子名称: DNA damage-binding protein 1, Mezigdomide, Protein cereblon, ... 著者 Watson, E.R, Lander, G.C. 登録日 2022-06-07 公開日 2022-07-20 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Molecular glue CELMoD compounds are regulators of cereblon conformation. Science, 378, 2022
8CVP	Cereblon-DDB1 in the Apo form 分子名称: DNA damage-binding protein 1, Protein cereblon, ZINC ION 著者 Watson, E.R, Lander, G.C. 登録日 2022-05-18 公開日 2022-07-20 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Molecular glue CELMoD compounds are regulators of cereblon conformation. Science, 378, 2022
8D7X	Cereblon~DDB1 in the Apo form with DDB1 in the hinged conformation 分子名称: DNA damage-binding protein 1, Protein cereblon, ZINC ION 著者 Watson, E.R, Lander, G.C. 登録日 2022-06-07 公開日 2022-07-20 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Molecular glue CELMoD compounds are regulators of cereblon conformation. Science, 378, 2022
8D7V	Cereblon~DDB1 bound to CC-92480 with DDB1 in the twisted conformation 分子名称: DNA damage-binding protein 1, Mezigdomide, Protein cereblon, ... 著者 Watson, E.R, Lander, G.C. 登録日 2022-06-07 公開日 2022-07-20 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Molecular glue CELMoD compounds are regulators of cereblon conformation. Science, 378, 2022

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