6PGA

WDR5delta32 bound to methyl (4-(4-(hydroxymethyl)-1H-imidazol-2-yl)butyl)carbamate

Summary for 6PGA

• Entry DOI: 10.2210/pdb6pga/pdb
• Related: 6PG3
• Descriptor: WD repeat-containing protein 5, methyl {4-[5-(hydroxymethyl)-1H-imidazol-2-yl]butyl}carbamate, SULFATE ION, ... (4 entities in total)
• Functional Keywords: inhibitor, scaffolding protein, b-propellor, chromatin regulator, protein binding, protein binding-inhibitor complex, protein binding/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 33860.34

Authors

Dennis, M.L.,Peat, T.S. (deposition date: 2019-06-24, release date: 2019-12-11, Last modification date: 2023-10-11)

• Primary citation: Dennis, M.L.,Morrow, B.J.,Dolezal, O.,Cuzzupe, A.N.,Stupple, A.E.,Newman, J.,Bentley, J.,Hattarki, M.,Nuttall, S.D.,Foitzik, R.C.,Street, I.P.,Stupple, P.A.,Monahan, B.J.,Peat, T.S.; Fragment screening for a protein-protein interaction inhibitor to WDR5.; Struct Dyn., 6:064701-064701, 2019; PubMed: 31768400; DOI: 10.1063/1.5122849

Experimental method

X-RAY DIFFRACTION (2.45 Å)