PDB: 377 件ウェブページステータス検索Chemie searchBIRD

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4OR9	Crystal structure of human calcineurin 分子名称: CALCIUM ION, Calcineurin subunit B type 1, FE (III) ION, ... 著者 Li, S.J, Wang, J, Wu, J.W, Wang, Z.X. 登録日 2014-02-11 公開日 2015-05-20 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Cooperative autoinhibition and multi-level activation mechanisms of calcineurin To be Published
1SU1	Structural and biochemical characterization of Yfce, a phosphoesterase from E. coli 分子名称: Hypothetical protein yfcE, SULFATE ION, ZINC ION 著者 Miller, D.J, Shuvalova, L, Evdokimova, E, Savchenko, A, Yakunin, A, Anderson, W.F, Midwest Center for Structural Genomics (MCSG) 登録日 2004-03-25 公開日 2004-08-17 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structural and biochemical characterization of a novel Mn2+-dependent phosphodiesterase encoded by the yfcE gene. Protein Sci., 16, 2007
6VC9	TB19 complex 分子名称: 1,2-ETHANEDIOL, 5'-nucleotidase, ecto (CD73), ... 著者 Zhou, Y.F, Lord, D.M. 登録日 2019-12-20 公開日 2020-11-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 A highly potent CD73 biparatopic antibody blocks organization of the enzyme active site through dual mechanisms. J.Biol.Chem., 295, 2020
6PJ3	Crystal structure of the Klebsiella pneumoniae LpxH/JH-LPH-33 complex 分子名称: 1,2-ETHANEDIOL, 1-[5-({4-[3-chloro-5-(trifluoromethyl)phenyl]piperazin-1-yl}sulfonyl)-2,3-dihydro-1H-indol-1-yl]ethan-1-one, MANGANESE (II) ION, ... 著者 Cho, J, Zhou, P. 登録日 2019-06-27 公開日 2020-02-12 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics. Proc.Natl.Acad.Sci.USA, 117, 2020
5I81	aSMase with zinc 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... 著者 Zhou, Y.F, Wei, R.R. 登録日 2016-02-18 公開日 2016-09-07 最終更新日 2021-03-24 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Human acid sphingomyelinase structures provide insight to molecular basis of Niemann-Pick disease. Nat Commun, 7, 2016
2HYO	Crystal structure of Rv0805 N97A mutant 分子名称: FE (III) ION, MANGANESE (II) ION, Rv0805N97A 著者 Shenoy, A.R, Capuder, M, Draskovic, P, Lamba, D, Visweswariah, S.S, Podobnik, M. 登録日 2006-08-07 公開日 2006-12-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structural and Biochemical Analysis of the Rv0805 Cyclic Nucleotide Phosphodiesterase from Mycobacterium tuberculosis. J.Mol.Biol., 365, 2007
6PIB	Structure of the Klebsiella pneumoniae LpxH-AZ1 complex 分子名称: 1-[5-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}sulfonyl)-2,3-dihydro-1H-indol-1-yl]ethan-1-one, MANGANESE (II) ION, TETRAETHYLENE GLYCOL, ... 著者 Cho, J, Zhou, P. 登録日 2019-06-26 公開日 2020-02-12 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics. Proc.Natl.Acad.Sci.USA, 117, 2020
5HPE	Phosphatase domain of PP5 bound to a phosphomimetic Cdc37 substrate peptide 分子名称: COBALT HEXAMMINE(III), MANGANESE (II) ION, Serine/threonine-protein phosphatase 5,Hsp90 co-chaperone Cdc37 著者 Oberoi, J, Mariotti, L, Vaughan, C. 登録日 2016-01-20 公開日 2016-07-27 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Structural and functional basis of protein phosphatase 5 substrate specificity. Proc.Natl.Acad.Sci.USA, 113, 2016
4XPN	Crystal Structure of Protein Phosphate 1 complexed with PP1 binding domain of GADD34 分子名称: GLYCEROL, MANGANESE (II) ION, PHOSPHATE ION, ... 著者 Choy, M.S, Peti, W, Page, R. 登録日 2015-01-17 公開日 2015-07-01 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.285 Å) 主引用文献 Structural and Functional Analysis of the GADD34:PP1 eIF2 alpha Phosphatase. Cell Rep, 11, 2015
7OV8	Crystal structure of pig purple acid phosphatase in complex with 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) and glycerol 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 Feder, D, McGeary, R.P, Guddat, L.W, Schenk, G. 登録日 2021-06-14 公開日 2022-03-23 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Rational Design of Potent Inhibitors of a Metallohydrolase Using a Fragment-Based Approach. Chemmedchem, 16, 2021
4JA9	Rat PP5 apo 分子名称: MAGNESIUM ION, Serine/threonine-protein phosphatase 5 著者 Haslbeck, V, Helmuth, M, Alte, F, Popowicz, G, Schmidt, W, Weiwad, M, Fischer, G, Gemmecker, G, Sattler, M, Striggow, F, Groll, M, Richter, K. 登録日 2013-02-18 公開日 2014-02-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism. Biosci.Rep., 35, 2015
3ICF	Structure of Protein serine/threonine phosphatase from Saccharomyces cerevisiae with similarity to human phosphatase PP5 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, FE (III) ION, ... 著者 Singer, A.U, Xu, X, Chang, C, Cui, H, Kagan, O, Edwards, A.M, Joachimiak, A, Yakunin, A.F, Savchenko, A, Midwest Center for Structural Genomics (MCSG) 登録日 2009-07-17 公開日 2009-08-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of Protein serine/threonine phosphatase from Saccharomyces cerevisiae with similarity to human phosphatase PP5 To be Published
4HD0	Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair 分子名称: DNA double-strand break repair protein Mre11, MANGANESE (II) ION 著者 Limbo, O, Moiani, D, Kertokalio, A, Wyman, C, Tainer, J.A, Russell, P. 登録日 2012-10-01 公開日 2012-10-31 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair. Nucleic Acids Res., 40, 2012
2BDX	X-ray Crystal Structure of dihydromicrocystin-LA bound to Protein Phosphatase-1 分子名称: DIHYDROMICROCYSTIN-LA, MANGANESE (II) ION, Serine/threonine protein phosphatase PP1-gamma catalytic subunit 著者 Maynes, J.T, Luu, H.A, Cherney, M.M, Andersen, R.J, Williams, D, Holmes, C.F, James, M.N. 登録日 2005-10-21 公開日 2006-01-17 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal Structures of Protein Phosphatase-1 Bound to Motuporin and Dihydromicrocystin-LA: Elucidation of the Mechanism of Enzyme Inhibition by Cyanobacterial Toxins. J.Mol.Biol., 356, 2006
4DSY	Crystal structure of red kidney bean purple acid phosphatase in complex with Maybridge fragment CC24201 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-phenylpyridine-3-carboxylic acid, ... 著者 Feder, D, Hussein, W.M, Clayton, D.J, Kan, M, Schenk, G, McGeary, R.P, Guddat, L.W. 登録日 2012-02-20 公開日 2012-09-19 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics. Chem.Biol.Drug Des., 80, 2012
6NUU	Structure of Calcineurin mutant in complex with NHE1 peptide 分子名称: CALCIUM ION, Calcineurin subunit B type 1, DI(HYDROXYETHYL)ETHER, ... 著者 Wang, X, Page, R, Peti, W. 登録日 2019-02-02 公開日 2019-07-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Molecular basis for the binding and selective dephosphorylation of Na+/H+exchanger 1 by calcineurin. Nat Commun, 10, 2019
2P6B	Crystal Structure of Human Calcineurin in Complex with PVIVIT Peptide 分子名称: CALCIUM ION, Calcineurin subunit B isoform 1, Calmodulin-dependent calcineurin A subunit alpha isoform, ... 著者 Li, H, Zhang, L, Rao, A, Harrison, S.C, Hogan, P.G. 登録日 2007-03-16 公開日 2007-06-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of calcineurin in complex with PVIVIT peptide: Portrait of a low-affinity signalling interaction J.Mol.Biol., 369, 2007
4O24	DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities 分子名称: (5~{Z})-5-[(4-hydroxyphenyl)methylidene]-3-(2-methylpropyl)-2-sulfanylidene-1,3-thiazolidin-4-one, Exonuclease, putative, ... 著者 Shibata, A, Moiani, D, Arvai, A.S, Perry, J, Harding, S.M, Genois, M, Maity, R, Rossum-Fikkert, S, Kertokalio, A, Romoli, F, Ismail, A, Ismalaj, E, Petricci, E, Neale, M.J, Bristow, R.G, Masson, J, Wyman, C, Jeggo, P.A, Tainer, J.A. 登録日 2013-12-16 公開日 2014-01-15 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities. Mol.Cell, 53, 2014
6OF5	The crystal structure of dodecyloxy(naphthalen-1-yl)methylphosphonic acid in complex with red kidney bean purple acid phosphatase 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, FE (III) ION, ... 著者 Feder, D, Schenk, G, Guddat, L.W, Hussein, W.M, McGeary, R.P. 登録日 2019-03-28 公開日 2019-09-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosis. Eur.J.Med.Chem., 182, 2019
1S8E	Crystal structure of Mre11-3 分子名称: MANGANESE (II) ION, exonuclease putative 著者 Hopfner, K.P. 登録日 2004-02-02 公開日 2004-08-10 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural and functional analysis of Mre11-3 Nucleic Acids Res., 32, 2004
4DHL	Crystal structure of red kidney bean purple acid phosphatase in complex with Maybridge fragment MO07123 分子名称: 1,2-ETHANEDIOL, 2-(4-methylphenyl)-1,3-thiazole-4-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Feder, D, Clayton, D.J, Hussein, W.M, Schenk, G, McGeary, R, Guddat, L.W. 登録日 2012-01-29 公開日 2012-12-12 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics. Chem.Biol.Drug Des., 80, 2012
1T70	Crystal structure of a novel phosphatase from Deinococcus radiodurans 分子名称: Phosphatase 著者 Shin, D.H, Wang, W, Kim, R, Yokota, H, Kim, S.H, Berkeley Structural Genomics Center (BSGC) 登録日 2004-05-07 公開日 2004-12-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural and enzymatic characterization of DR1281: A calcineurin-like phosphoesterase from Deinococcus radiodurans. Proteins, 70, 2008
4O5G	DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities 分子名称: (5~{E})-5-[(4-aminophenyl)methylidene]-2-azanylidene-1,3-thiazolidin-4-one, Exonuclease, putative, ... 著者 Shibata, A, Moiani, D, Arvai, A.S, Perry, J, Harding, S.M, Genois, M, Maity, R, Rossum-Fikkert, S, Kertokalio, A, Romoli, F, Ismail, A, Ismalaj, E, Petricci, E, Neale, M.J, Bristow, R.G, Masson, J, Wyman, C, Jeggo, P.A, Tainer, J.A. 登録日 2013-12-19 公開日 2014-01-08 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.301 Å) 主引用文献 DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities. Mol.Cell, 53, 2014
1OIE	5'-Nucleotidase (E. coli) with an Engineered Disulfide Bridge (S228C, P513C) 分子名称: NICKEL (II) ION, PROTEIN USHA 著者 Schultz-Heienbrok, R, Maier, T, Straeter, N. 登録日 2003-06-16 公開日 2004-08-05 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 Trapping a 96 Degree Domain Rotation in Two Distinct Conformations by Engineered Disulfide Bridges Protein Sci., 13, 2004
6X1Y	Mre11 dimer in complex with small molecule modulator PFMI 分子名称: (5Z)-5-[(3-methoxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Nuclease SbcCD subunit D 著者 Arvai, A.S, Moiani, D, Tainer, J.A. 登録日 2020-05-19 公開日 2020-06-10 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response. Prog.Biophys.Mol.Biol., 163, 2021

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