6PJ3
Crystal structure of the Klebsiella pneumoniae LpxH/JH-LPH-33 complex
Summary for 6PJ3
Entry DOI | 10.2210/pdb6pj3/pdb |
Descriptor | UDP-2,3-diacylglucosamine hydrolase, MANGANESE (II) ION, 1-[5-({4-[3-chloro-5-(trifluoromethyl)phenyl]piperazin-1-yl}sulfonyl)-2,3-dihydro-1H-indol-1-yl]ethan-1-one, ... (5 entities in total) |
Functional Keywords | lpxh, lipid a, jh-lph-33, biosynthetic protein |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 1 |
Total formula weight | 30349.61 |
Authors | |
Primary citation | Cho, J.,Lee, M.,Cochrane, C.S.,Webster, C.G.,Fenton, B.A.,Zhao, J.,Hong, J.,Zhou, P. Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics. Proc.Natl.Acad.Sci.USA, 117:4109-4116, 2020 Cited by PubMed: 32041866DOI: 10.1073/pnas.1912876117 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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