6PIB

Structure of the Klebsiella pneumoniae LpxH-AZ1 complex

Summary for 6PIB

Entry DOI	10.2210/pdb6pib/pdb
Descriptor	UDP-2,3-diacylglucosamine hydrolase, MANGANESE (II) ION, 1-[5-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}sulfonyl)-2,3-dihydro-1H-indol-1-yl]ethan-1-one, ... (5 entities in total)
Functional Keywords	lipid a, lpxh, az1, inhibitor, biosynthetic protein
Biological source	Klebsiella pneumoniae
Total number of polymer chains	1
Total formula weight	30872.84
Authors	Cho, J.,Zhou, P. (deposition date: 2019-06-26, release date: 2020-02-12, Last modification date: 2023-10-11)
Primary citation	Cho, J.,Lee, M.,Cochrane, C.S.,Webster, C.G.,Fenton, B.A.,Zhao, J.,Hong, J.,Zhou, P. Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics. Proc.Natl.Acad.Sci.USA, 117:4109-4116, 2020 Cited by PubMed: 32041866 DOI: 10.1073/pnas.1912876117 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.26 Å)

Structure validation