6X1Y
Mre11 dimer in complex with small molecule modulator PFMI
Summary for 6X1Y
Entry DOI | 10.2210/pdb6x1y/pdb |
Descriptor | Nuclease SbcCD subunit D, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, (5Z)-5-[(3-methoxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one, ... (4 entities in total) |
Functional Keywords | dna repair mre11 thermophilic nuclease, dna double-strand break repair, hydrolase |
Biological source | Thermotoga maritima |
Total number of polymer chains | 2 |
Total formula weight | 78043.55 |
Authors | Arvai, A.S.,Moiani, D.,Tainer, J.A. (deposition date: 2020-05-19, release date: 2020-06-10, Last modification date: 2023-10-18) |
Primary citation | Wilson 3rd, D.M.,Deacon, A.M.,Duncton, M.A.J.,Pellicena, P.,Georgiadis, M.M.,Yeh, A.P.,Arvai, A.S.,Moiani, D.,Tainer, J.A.,Das, D. Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response. Prog.Biophys.Mol.Biol., 163:130-142, 2021 Cited by PubMed: 33115610DOI: 10.1016/j.pbiomolbio.2020.10.005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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