4DHL

Crystal structure of red kidney bean purple acid phosphatase in complex with Maybridge fragment MO07123

Summary for 4DHL

Entry DOI	10.2210/pdb4dhl/pdb
Descriptor	Purple acid phosphatase, 2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-L-fucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
Functional Keywords	catalytic c domain, n terminal domain, phosphatase, acid phosphatase, phosphoric monoester hydrolases, hydrolase, mo07123, maybridge, fragment, lysosome
Biological source	Phaseolus vulgaris (French bean,kidney bean,string bean)
Total number of polymer chains	4
Total formula weight	206786.41
Authors	Feder, D.,Clayton, D.J.,Hussein, W.M.,Schenk, G.,McGeary, R.,Guddat, L.W. (deposition date: 2012-01-29, release date: 2012-12-12, Last modification date: 2020-07-29)
Primary citation	Feder, D.,Hussein, W.M.,Clayton, D.J.,Kan, M.W.,Schenk, G.,McGeary, R.P.,Guddat, L.W. Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics. Chem.Biol.Drug Des., 80:665-674, 2012 Cited by PubMed: 22943065 DOI: 10.1111/cbdd.12001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation