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6WA4
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Solution NMR structure of the unmyristoylated feline immunodeficiency virus matrix protein
分子名称: Matrix protein
著者Brown, J.B, Summers, H.R, Brown, L.A, Marchant, J, Canova, P.N, O'Hern, C.T, Abbott, S.T, Nyaunu, C, Maxwell, S, Johnson, T, Moser, M.B, Carter, H, Ablan, S, Freed, E.O, Summers, M.F.
登録日2020-03-24
公開日2020-07-22
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Structural and Mechanistic Studies of the Rare Myristoylation Signal of the Feline Immunodeficiency Virus.
J.Mol.Biol., 432, 2020
6WA5
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Solution NMR Structure of the G4L/Q5K/G6S (NOS) Unmyristoylated Feline Immunodeficiency Virus Matrix Protein
分子名称: Matrix protein
著者Brown, J.B, Summers, H.R, Brown, L.A, Marchant, J, Canova, P.N, O'Hern, C.T, Abbott, S.T, Nyaunu, C, Maxwell, S, Johnson, T, Moser, M.B, Ablan, S.A, Carter, H, Freed, E.O, Summers, M.F.
登録日2020-03-24
公開日2020-07-22
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Structural and Mechanistic Studies of the Rare Myristoylation Signal of the Feline Immunodeficiency Virus.
J.Mol.Biol., 432, 2020
6Y8O
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Mycobacterium smegmatis GyrB 22kDa ATPase sub-domain in complex with novobiocin
分子名称: 1,2-ETHANEDIOL, ACETATE ION, DNA gyrase subunit B, ...
著者Henderson, S.R, Stevenson, C.E.M, Malone, B, Zholnerovych, Y, Mitchenall, L.A, Pichowicz, M, McGarry, D.H, Cooper, I.R, Charrier, C, Salisbury, A, Lawson, D.M, Maxwell, A.
登録日2020-03-05
公開日2020-08-12
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural and mechanistic analysis of ATPase inhibitors targeting mycobacterial DNA gyrase.
J.Antimicrob.Chemother., 75, 2020
6Y8N
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Mycobacterium thermoresistibile GyrB21 in complex with Redx03863
分子名称: 1,2-ETHANEDIOL, 4-[(1~{S},5~{R})-6-azanyl-3-azabicyclo[3.1.0]hexan-3-yl]-6-fluoranyl-~{N}-methyl-2-(2-methylpyrimidin-5-yl)oxy-9~{H}-pyrimido[4,5-b]indol-8-amine, DNA gyrase subunit B, ...
著者Henderson, S.R, Stevenson, C.E.M, Malone, B, Zholnerovych, Y, Mitchenall, L.A, Pichowicz, M, McGarry, D.H, Cooper, I.R, Charrier, C, Salisbury, A, Lawson, D.M, Maxwell, A.
登録日2020-03-05
公開日2020-08-12
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural and mechanistic analysis of ATPase inhibitors targeting mycobacterial DNA gyrase.
J.Antimicrob.Chemother., 75, 2020
1PSD
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THE ALLOSTERIC LIGAND SITE IN THE VMAX-TYPE COOPERATIVE ENZYME PHOSPHOGLYCERATE DEHYDROGENASE
分子名称: D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PHOSPHOGLYCERATE DEHYDROGENASE), NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SERINE
著者Schuller, D.J, Grant, G.A, Banaszak, L.J.
登録日1995-05-02
公開日1995-07-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献The allosteric ligand site in the Vmax-type cooperative enzyme phosphoglycerate dehydrogenase.
Nat.Struct.Biol., 2, 1995
6Y8L
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Mycobacterium thermoresistibile GyrB21 in complex with novobiocin
分子名称: 1,2-ETHANEDIOL, DNA gyrase subunit B, NOVOBIOCIN, ...
著者Henderson, S.R, Stevenson, C.E.M, Malone, B, Zholnerovych, Y, Mitchenall, L.A, Pichowicz, M, McGarry, D.H, Cooper, I.R, Charrier, C, Salisbury, A, Lawson, D.M, Maxwell, A.
登録日2020-03-05
公開日2020-08-12
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structural and mechanistic analysis of ATPase inhibitors targeting mycobacterial DNA gyrase.
J.Antimicrob.Chemother., 75, 2020
1TON
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BU of 1ton by Molmil
RAT SUBMAXILLARY GLAND SERINE PROTEASE, TONIN. STRUCTURE SOLUTION AND REFINEMENT AT 1.8 ANGSTROMS RESOLUTION
分子名称: TONIN, ZINC ION
著者Fujinaga, M, James, M.N.G.
登録日1987-06-03
公開日1988-01-16
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Rat submaxillary gland serine protease, tonin. Structure solution and refinement at 1.8 A resolution.
J.Mol.Biol., 195, 1987
1RA4
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Crystal structure of the Methanococcus jannaschii L7Ae protein
分子名称: 50S ribosomal protein L7Ae
著者Suryadi, J, Tran, E.J, Maxwell, E.S, Brown, B.A.
登録日2003-10-31
公開日2004-11-16
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献The crystal structure of the Methanocaldococcus jannaschii multifunctional L7Ae RNA-binding protein reveals an induced-fit interaction with the box C/D RNAs.
Biochemistry, 44, 2005
2Y3P
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Crystal structure of N-terminal domain of GyrA with the antibiotic simocyclinone D8
分子名称: DNA GYRASE SUBUNIT A, MAGNESIUM ION, SIMOCYCLINONE D8
著者Edwards, M.J, Flatman, R.H, Mitchenall, L.A, Stevenson, C.E.M, Le, T.B.K, Clarke, T.A, McKay, A.R, Fiedler, H.-P, Buttner, M.J, Lawson, D.M, Maxwell, A.
登録日2010-12-22
公開日2010-12-29
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.62 Å)
主引用文献A Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8, Bound to DNA Gyrase.
Science, 326, 2009
7JQD
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Crystal Structure of PAC1r in complex with peptide antagonist
分子名称: Peptide-43, Pituitary adenylate cyclase-activating polypeptide type I receptor
著者Piper, D.E, Hu, E, Fang-Tsao, H.
登録日2020-08-10
公開日2021-03-24
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Discovery of Selective Pituitary Adenylate Cyclase 1 Receptor (PAC1R) Antagonist Peptides Potent in a Maxadilan/PACAP38-Induced Increase in Blood Flow Pharmacodynamic Model.
J.Med.Chem., 64, 2021
8F3K
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Anti-CRISPR protein AcrIIC5 inhibits CRISPR-Cas9 by acting as a DNA mimic
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACRIIC5Nch, AMMONIUM ION, ...
著者Shah, M, Sungwon, H, Davidson, A.R, Maxwell, K.L, Moraes, T.F.
登録日2022-11-10
公開日2023-03-08
最終更新日2023-04-12
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Anti-CRISPR Protein AcrIIC5 Inhibits CRISPR-Cas9 by Occupying the Target DNA Binding Pocket.
J.Mol.Biol., 435, 2023
1GU8
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SENSORY RHODOPSIN II
分子名称: CHLORIDE ION, RETINAL, SENSORY RHODOPSIN II
著者Edman, K, Royant, A, Nollert, P, Maxwell, C.A, Pebay-Peyroula, E, Navarro, J, Neutze, R, Landau, E.M.
登録日2002-01-24
公開日2002-04-12
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Early Structural Rearrangements in the Photocycle of an Integral Membrane Sensory Receptor
Structure, 10, 2002
1GUE
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SENSORY RHODOPSIN II
分子名称: CHLORIDE ION, RETINAL, SENSORY RHODOPSIN II
著者Edman, K, Royant, A, Nollert, P, Maxwell, C.A, Pebay-Peyroula, E, Navarro, J, Neutze, R, Landau, E.M.
登録日2002-01-24
公開日2002-04-12
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Early Structural Rearrangements in the Photocycle of an Integral Membrane Sensory Receptor
Structure, 10, 2002
1VJQ
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Designed protein based on backbone conformation of procarboxypeptidase-A (1AYE) with sidechains chosen for maximal predicted stability.
分子名称: designed protein
著者Merritt, E.A, Baker, D, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日2004-03-19
公開日2004-03-30
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.098 Å)
主引用文献Designed protein based on backbone conformation of procarboxypeptidase-A (1AYE) with sidechains chosen for maximal predicted stability.
To be Published
2Y31
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Simocyclinone C4 bound form of TetR-like repressor SimR
分子名称: CALCIUM ION, CHLORIDE ION, PENTAETHYLENE GLYCOL, ...
著者Le, T.B.K, Stevenson, C.E.M, Fiedler, H.-P, Maxwell, A, Lawson, D.M, Buttner, M.J.
登録日2010-12-17
公開日2011-03-09
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structures of the Tetr-Like Simocyclinone Efflux Pump Repressor, Simr, and the Mechanism of Ligand-Mediated Derepression.
J.Mol.Biol., 408, 2011
2Y2Z
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BU of 2y2z by Molmil
ligand-free form of TetR-like repressor SimR
分子名称: PUTATIVE REPRESSOR SIMREG2
著者Le, T.B.K, Stevenson, C.E.M, Fiedler, H.-P, Maxwell, A, Lawson, D.M, Buttner, M.J.
登録日2010-12-17
公開日2011-03-09
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structures of the Tetr-Like Simocyclinone Efflux Pump Repressor, Simr, and the Mechanism of Ligand-Mediated Derepression.
J.Mol.Biol., 408, 2011
2Y30
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Simocyclinone D8 bound form of TetR-like repressor SimR
分子名称: CHLORIDE ION, PUTATIVE REPRESSOR SIMREG2, SIMOCYCLINONE D8
著者Le, T.B.K, Stevenson, C.E.M, Fiedler, H.-P, Maxwell, A, Lawson, D.M, Buttner, M.J.
登録日2010-12-17
公開日2011-03-09
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structures of the Tetr-Like Simocyclinone Efflux Pump Repressor, Simr, and the Mechanism of Ligand-Mediated Derepression.
J.Mol.Biol., 408, 2011
8JZM
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BU of 8jzm by Molmil
The inhibitor of Toll-like receptor signaling o-vanillin binds covalently to MAL/TIRAP Lys-210
分子名称: Toll/interleukin-1 receptor domain-containing adapter protein
著者Rahaman, M.H, Jia, X, Maxwell, M.J, Mobli, M, Kobe, B.
登録日2023-07-05
公開日2024-05-01
実験手法SOLUTION NMR
主引用文献o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2.
J Enzyme Inhib Med Chem, 39, 2024
1P2Y
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CRYSTAL STRUCTURE OF CYTOCHROME P450CAM IN COMPLEX WITH (S)-(-)-NICOTINE
分子名称: (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, Cytochrome P450-cam, PROTOPORPHYRIN IX CONTAINING FE
著者Strickler, M, Goldstein, B.M, Maxfield, K, Shireman, L, Kim, G, Matteson, D, Jones, J.P.
登録日2003-04-16
公開日2003-10-28
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystallographic Studies on the Complex Behavior of Nicotine Binding to P450cam (CYP101)(dagger).
Biochemistry, 42, 2003
1P7R
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CRYSTAL STRUCTURE OF REDUCED, CO-EXPOSED COMPLEX OF CYTOCHROME P450CAM WITH (S)-(-)-NICOTINE
分子名称: (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, Cytochrome P450-cam, PROTOPORPHYRIN IX CONTAINING FE
著者Strickler, M, Goldstein, B.M, Maxfield, K, Shireman, L, Kim, G, Matteson, D, Jones, J.P.
登録日2003-05-05
公開日2003-10-28
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Crystallographic Studies on the Complex Behavior of Nicotine Binding to P450cam (CYP101)(dagger).
Biochemistry, 42, 2003
5HJS
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BU of 5hjs by Molmil
Identification of LXRbeta selective agonists for the treatment of Alzheimer's Disease
分子名称: 2-chloro-4-{1'-[(2R)-2-hydroxy-3-methyl-2-(trifluoromethyl)butanoyl]-4,4'-bipiperidin-1-yl}-N,N-dimethylbenzamide, Nuclear receptor coactivator 1, Oxysterols receptor LXR-alpha, ...
著者Parthasarathy, G, Klein, D.
登録日2016-01-13
公開日2016-04-06
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Identification and in Vivo Evaluation of Liver X Receptor beta-Selective Agonists for the Potential Treatment of Alzheimer's Disease.
J.Med.Chem., 59, 2016
5HJP
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Identification of LXRbeta selective agonists for the treatment of Alzheimer's Disease
分子名称: 2-chloro-4-{1'-[(2R)-2-hydroxy-3-methyl-2-(trifluoromethyl)butanoyl]-4,4'-bipiperidin-1-yl}-N,N-dimethylbenzamide, DI(HYDROXYETHYL)ETHER, Oxysterols receptor LXR-beta, ...
著者Parthasarathy, G, Klein, D.
登録日2016-01-13
公開日2016-04-06
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Identification and in Vivo Evaluation of Liver X Receptor beta-Selective Agonists for the Potential Treatment of Alzheimer's Disease.
J.Med.Chem., 59, 2016
1Z1Z
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NMR structure of the gpu tail protein from lambda bacteriophage
分子名称: Minor tail protein U
著者Edmonds, L, Maxwell, K, Davidson, A, Donaldson, L.W.
登録日2005-03-07
公開日2006-04-18
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献The NMR structure of the gpU tail-terminator protein from bacteriophage lambda: identification of sites contributing to Mg(II)-mediated oligomerization and biological function.
J.Mol.Biol., 365, 2007
6F8J
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Crystal Structure of E. coli GyraseB 24kDa in complex with 6-[(ethylcarbamoyl)amino]-4-(1H-pyrazol-1-yl)-N-(pyridin-3-yl)pyridine-3-carboxamide
分子名称: 6-(ethylcarbamoylamino)-4-pyrazol-1-yl-~{N}-pyridin-3-yl-pyridine-3-carboxamide, DNA gyrase subunit B
著者Narramore, S.K, Stevenson, C.E.M, Lawson, D.M, Maxwell, A, Fishwick, C.W.G.
登録日2017-12-13
公開日2019-06-26
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase.
Bioorg.Med.Chem., 27, 2019
6F96
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Crystal Structure of E. coli GyraseB 24kDa in complex with 6-[(ethylcarbamoyl)amino]-4-[(4-methoxyphenyl)amino]-N-(pyridin-3-yl)pyridine-3-carboxamide
分子名称: 6-(ethylcarbamoylamino)-4-[(4-methoxyphenyl)amino]-~{N}-pyridin-3-yl-pyridine-3-carboxamide, DNA gyrase subunit B
著者Narramore, S.K, Stevenson, C.E.M, Lawson, D.M, Maxwell, A, Fishwick, C.W.G.
登録日2017-12-14
公開日2019-01-30
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase.
Bioorg.Med.Chem., 27, 2019

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