5HJS

Identification of LXRbeta selective agonists for the treatment of Alzheimer's Disease

Summary for 5HJS

• Entry DOI: 10.2210/pdb5hjs/pdb
• Related: 5HJP
• Descriptor: Oxysterols receptor LXR-alpha, Nuclear receptor coactivator 1, 2-chloro-4-{1'-[(2R)-2-hydroxy-3-methyl-2-(trifluoromethyl)butanoyl]-4,4'-bipiperidin-1-yl}-N,N-dimethylbenzamide, ... (5 entities in total)
• Functional Keywords: agonist, alzheimer's, signaling protein
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : Q13133 Q15788
• Total number of polymer chains: 4
• Total formula weight: 72573.26

Authors

Parthasarathy, G.,Klein, D. (deposition date: 2016-01-13, release date: 2016-04-06, Last modification date: 2024-03-06)

• Primary citation: Stachel, S.J.,Zerbinatti, C.,Rudd, M.T.,Cosden, M.,Suon, S.,Nanda, K.K.,Wessner, K.,DiMuzio, J.,Maxwell, J.,Wu, Z.,Uslaner, J.M.,Michener, M.S.,Szczerba, P.,Brnardic, E.,Rada, V.,Kim, Y.,Meissner, R.,Wuelfing, P.,Yuan, Y.,Ballard, J.,Holahan, M.,Klein, D.J.,Lu, J.,Fradera, X.,Parthasarathy, G.,Uebele, V.N.,Chen, Z.,Li, Y.,Li, J.,Cooke, A.J.,Bennett, D.J.,Bilodeau, M.T.,Renger, J.; Identification and in Vivo Evaluation of Liver X Receptor beta-Selective Agonists for the Potential Treatment of Alzheimer's Disease.; J.Med.Chem., 59:3489-3498, 2016; PubMed: 27011007; DOI: 10.1021/acs.jmedchem.6b00176

Experimental method

X-RAY DIFFRACTION (1.72 Å)